PT-141 (Bremelanotide) vs Semax
Side-by-side comparison of PT-141 (Bremelanotide) and Semax: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
PT-141 (Bremelanotide)
Semax
PT-141 (Bremelanotide)
PT-141 (bremelanotide) is a cyclic 7-amino-acid synthetic melanocortin receptor agonist that acts centrally in the brain — not peripherally on genital tissue — to improve sexual desire, arousal, and responsiveness. It is…
Lowest listed price: $34.99 across 5 listings
Full PT-141 (Bremelanotide) profileSemax
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro, MEHFPGP, 813 Da molecular weight) developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1980s. The compound is derived…
Lowest listed price: $32.90 across 5 listings
Full Semax profileSide-by-side comparison
| Attribute | PT-141 (Bremelanotide) | Semax |
|---|---|---|
| Category | Skin, Hair & Aesthetics | Nootropics |
| Research Stage | FDA Approved | Approved (Russia, since mid-1990s for stroke and cognitive disorders) |
| Mechanism of Action | Melanocortin Receptor Pharmacology PT-141 is a synthetic cyclic heptapeptide (Ac-Nle-cyclo[Asp-His-DPhe-Arg-Trp-Lys]-OH) that binds the melanocortin receptor family with the following selectivity profile: | Receptor | Primary Location | PT-141 Activity |… | Primary Mechanism: Multi-Pathway Neurotrophic Activation Semax produces its effects through coordinated activation of multiple neurotrophic, neurotransmitter, and neuroprotective pathways. Unlike conventional nootropics that target a single system (modafinil… |
| Half-Life | ~2.7 hours | ~2-3 minutes plasma half-life (functional neurological effects persist 12-24 hours due to BDNF/NGF gene expression changes) |
| Typical Dose Range | 500–2,000 mcg (0.5–2 mg) per dose | 100-900 mcg intranasal daily (0.1% solution: 2-3 drops per nostril 2-3x daily); 1% solution used for acute stroke in Russian clinical protocols |
| Dosing Frequency | As needed, 45 minutes before sexual activity; max once per 24 hours, max 8 doses/month | Intranasal 1–3 times daily |
| Administration | Subcutaneous | Intranasal |
| Side Effects | Very Common (10% of users) - Nausea — By far the most common adverse effect, affecting approximately 40% of users in the RECONNECT trials. Usually mild-to-moderate, begins within 30-60 minutes of injection, resolves within 2-4 hours. Can be mitigated with… | Overall Safety Profile Semax has an excellent safety profile across 20+ years of Russian clinical use. In acute stroke trials, cognitive studies, and pediatric applications, Semax has demonstrated consistent tolerability with minimal adverse event burden. This… |
| Molecular Weight | 1025.2 Da | 813.9 Da |
| Common Vial Sizes | 2mg, 10mg | 5mg, 10mg |
Price History
5 data points- BM
- Half Nattys
- Ion Peptide
- BHG Labs
Price History
5 data points- OF
- Half Nattys
- Ion Peptide
- BHG Labs
PT-141 (Bremelanotide): potential benefits
- Sexual desire enhancement
- HSDD treatment
- Erectile dysfunction (central mechanism)
- Non-hormonal approach
Semax: potential benefits
- Rapid BDNF/TrkB upregulation in the hippocampus, supporting synaptic plasticity and learning (PMID: 16996037)
- Neuroprotective, immunomodulatory gene-expression changes in focal cerebral ischemia (middle cerebral artery occlusion) models (PMID: 28255762)
- Cognitive enhancement including improved attention, working memory, and processing speed
- Dopaminergic modulation that may support motivation and executive function (preclinical data)
- Stroke recovery facilitation - accelerated functional recovery and improved Barthel Index in ischemic stroke patients; approved in Russia for ischemic stroke (PMID: 29798983)
- Anxiolytic and anti-asthenic effects reported in Russian clinical use, attributed to neurotrophic and monoaminergic modulation
- Non-addictive cognitive support without tolerance development or withdrawal at standard doses
Frequently asked
What's the difference between PT-141 (Bremelanotide) and Semax?
PT-141 (Bremelanotide) is a skin, hair & aesthetics that melanocortin receptor pharmacology pt-141 is a synthetic cyclic heptapeptide (ac-nle-cyclo[asp-his-dphe-arg-trp-lys]-oh) that binds the melanocortin receptor family with the…. Semax is a nootropics that primary mechanism: multi-pathway neurotrophic activation semax produces its effects through coordinated activation of multiple neurotrophic, neurotransmitter, and neuroprotective…. The two differ in mechanism, half-life (~2.7 hours vs ~2-3 minutes plasma half-life (functional neurological effects persist 12-24 hours due to BDNF/NGF gene expression changes)), and typical dose range.
Which has the longer half-life, PT-141 (Bremelanotide) or Semax?
PT-141 (Bremelanotide) has a half-life of ~2.7 hours. Semax has a half-life of ~2-3 minutes plasma half-life (functional neurological effects persist 12-24 hours due to BDNF/NGF gene expression changes). Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, PT-141 (Bremelanotide) or Semax?
Lowest listed price on BodyHackGuide: PT-141 (Bremelanotide) from $34.99, Semax from $32.90. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack PT-141 (Bremelanotide) and Semax?
Stacking depends on mechanism overlap, safety profile, and goals. PT-141 (Bremelanotide) and Semax should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.