PT-141 (Bremelanotide) vs Selank
Side-by-side comparison of PT-141 (Bremelanotide) and Selank: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
PT-141 (Bremelanotide)
Selank
PT-141 (Bremelanotide)
PT-141 (bremelanotide) is a cyclic 7-amino-acid synthetic melanocortin receptor agonist that acts centrally in the brain — not peripherally on genital tissue — to improve sexual desire, arousal, and responsiveness. It is…
Lowest listed price: $34.99 across 5 listings
Full PT-141 (Bremelanotide) profileSelank
Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro, 750 Da molecular weight) developed in the 1990s at the Institute of Molecular Genetics of the Russian Academy of Sciences as a synthetic analog of tuftsin…
Lowest listed price: $25.00 across 6 listings
Full Selank profileSide-by-side comparison
| Attribute | PT-141 (Bremelanotide) | Selank |
|---|---|---|
| Category | Skin, Hair & Aesthetics | Nootropics |
| Research Stage | FDA Approved | Approved (Russia, as anxiolytic and nootropic medication) |
| Mechanism of Action | Melanocortin Receptor Pharmacology PT-141 is a synthetic cyclic heptapeptide (Ac-Nle-cyclo[Asp-His-DPhe-Arg-Trp-Lys]-OH) that binds the melanocortin receptor family with the following selectivity profile: | Receptor | Primary Location | PT-141 Activity |… | Primary Mechanism: Multi-System Neurochemical Modulation Selank does not have a single clean receptor-binding mechanism. Unlike benzodiazepines (GABA-A positive allosteric modulators), SSRIs (serotonin reuptake inhibition), or buspirone (5-HT1A partial… |
| Half-Life | ~2.7 hours | ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation) |
| Typical Dose Range | 500–2,000 mcg (0.5–2 mg) per dose | 250-750 mcg intranasal daily (0.15% solution: 2-3 drops per nostril 2-3x daily); typical course is 14-21 days |
| Dosing Frequency | As needed, 45 minutes before sexual activity; max once per 24 hours, max 8 doses/month | Intranasal 1–3 times daily |
| Administration | Subcutaneous | Intranasal |
| Side Effects | Very Common (10% of users) - Nausea — By far the most common adverse effect, affecting approximately 40% of users in the RECONNECT trials. Usually mild-to-moderate, begins within 30-60 minutes of injection, resolves within 2-4 hours. Can be mitigated with… | Overall Safety Profile Selank has one of the best safety profiles in the anxiolytic space. Over 15+ years of Russian clinical use and research, the compound has been associated with essentially no serious adverse events at therapeutic doses. This compares… |
| Molecular Weight | 1025.2 Da | 751.9 Da |
| Common Vial Sizes | 2mg, 10mg | 5mg, 10mg |
Price History
5 data points- BM
- Half Nattys
- Ion Peptide
- BHG Labs
Price History
5 data points- OF
- Half Nattys
- Ion Peptide
- BHG Labs
PT-141 (Bremelanotide): potential benefits
- Sexual desire enhancement
- HSDD treatment
- Erectile dysfunction (central mechanism)
- Non-hormonal approach
Selank: potential benefits
- Anxiolytic effects comparable to benzodiazepines but without sedation or dependence in Russian clinical trials (PMID: 18454096)
- Positive allosteric modulation of brain GABA receptors through a non-benzodiazepine binding site (PMID: 30255741)
- Immunomodulation via Th1/Th2 cytokine balance and IL-6 regulation in patients with anxiety-asthenic disorders (PMID: 18577961)
- Cognitive and memory support linked to BDNF upregulation in the hippocampus in preclinical models (PMID: 18841804)
- Modulation of the endogenous enkephalin-opioid system supporting mood and stress tolerance (PMID: 22550852)
- Anti-inflammatory and adaptogenic effects through normalization of stress-induced cytokine dysregulation
- Non-addictive anxiolytic profile - no tolerance, withdrawal, or dependence reported across years of Russian clinical use
Frequently asked
What's the difference between PT-141 (Bremelanotide) and Selank?
PT-141 (Bremelanotide) is a skin, hair & aesthetics that melanocortin receptor pharmacology pt-141 is a synthetic cyclic heptapeptide (ac-nle-cyclo[asp-his-dphe-arg-trp-lys]-oh) that binds the melanocortin receptor family with the…. Selank is a nootropics that primary mechanism: multi-system neurochemical modulation selank does not have a single clean receptor-binding mechanism. unlike benzodiazepines (gaba-a positive allosteric…. The two differ in mechanism, half-life (~2.7 hours vs ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation)), and typical dose range.
Which has the longer half-life, PT-141 (Bremelanotide) or Selank?
PT-141 (Bremelanotide) has a half-life of ~2.7 hours. Selank has a half-life of ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation). Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, PT-141 (Bremelanotide) or Selank?
Lowest listed price on BodyHackGuide: PT-141 (Bremelanotide) from $34.99, Selank from $25.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack PT-141 (Bremelanotide) and Selank?
Stacking depends on mechanism overlap, safety profile, and goals. PT-141 (Bremelanotide) and Selank should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.