Selank vs Phenibut
Independent, side-by-side comparison of Selank and Phenibut: mechanism, half-life, dose range, safety profile, and live vendor pricing. Updated continuously as new research and listings land.
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Selank
Phenibut
Selank
Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro, 750 Da molecular weight) developed in the 1990s at the Institute of Molecular Genetics of the Russian Academy of Sciences as a synthetic analog of tuftsin…
Live lowest price: $25.00 across 6 vendors
Full Selank profilePhenibut
Phenibut is the common Western name for β-phenyl-γ-aminobutyric acid (beta-phenyl-GABA; Russian trade names Phenibut/Фенибут, Noofen, Anvifen), a Soviet-era anxiolytic and nootropic developed in the 1960s at the Herzen…
Full Phenibut profileSide-by-side comparison
| Attribute | Selank | Phenibut |
|---|---|---|
| Category | Nootropics | Nootropics |
| Research Stage | Approved (Russia, as anxiolytic and nootropic medication) | Prescription Medicine (Russia/CIS) / Unregulated Elsewhere |
| Mechanism of Action | Primary Mechanism: Multi-System Neurochemical Modulation Selank does not have a single clean receptor-binding mechanism. Unlike benzodiazepines (GABA-A positive allosteric modulators), SSRIs (serotonin reuptake inhibition), or buspirone (5-HT1A partial… | Phenibut's pharmacology is dominated by activity at the GABA-B receptor, with secondary effects at GABA-A receptors and voltage-gated calcium channels. Understanding these three components is essential to understanding both its therapeutic effects and its… |
| Half-Life | ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation) | 5-8 hours (plasma); central CNS effect 10-16 hours |
| Typical Dose Range | 250-750 mcg intranasal daily (0.15% solution: 2-3 drops per nostril 2-3x daily); typical course is 14-21 days | — |
| Dosing Frequency | Intranasal 1–3 times daily | — |
| Administration | Intranasal | Oral |
| Side Effects | Overall Safety Profile Selank has one of the best safety profiles in the anxiolytic space. Over 15+ years of Russian clinical use and research, the compound has been associated with essentially no serious adverse events at therapeutic doses. This compares… | Phenibut's side effects fall into three categories: acute-dose effects (largely dose-dependent sedation and impairment), withdrawal effects (physiologically similar to benzodiazepine/alcohol withdrawal), and interactions with other CNS depressants (additive… |
| Molecular Weight | 751.9 Da | 179.22 g/mol (free base); 215.68 g/mol (HCl salt) |
| Common Vial Sizes | 5mg, 10mg | — |
Price History
6 data points- OF
- Unknown
- VANDL Labs
- Unknown
- Ion Peptide
- BHG Labs
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Selank — potential benefits
- Anxiolytic effects comparable to benzodiazepines but without sedation or dependence in Russian clinical trials (PMID: 18454096)
- Positive allosteric modulation of brain GABA receptors through a non-benzodiazepine binding site (PMID: 30255741)
- Immunomodulation via Th1/Th2 cytokine balance and IL-6 regulation in patients with anxiety-asthenic disorders (PMID: 18577961)
- Cognitive and memory support linked to BDNF upregulation in the hippocampus in preclinical models (PMID: 18841804)
- Modulation of the endogenous enkephalin-opioid system supporting mood and stress tolerance (PMID: 22550852)
- Anti-inflammatory and adaptogenic effects through normalization of stress-induced cytokine dysregulation
- Non-addictive anxiolytic profile - no tolerance, withdrawal, or dependence reported across years of Russian clinical use
Phenibut — potential benefits
- No structured benefit list published.
Frequently asked
What's the difference between Selank and Phenibut?
Selank is a nootropics that primary mechanism: multi-system neurochemical modulation selank does not have a single clean receptor-binding mechanism. unlike benzodiazepines (gaba-a positive allosteric…. Phenibut is a nootropics that phenibut's pharmacology is dominated by activity at the gaba-b receptor, with secondary effects at gaba-a receptors and voltage-gated calcium channels. understanding these three…. The two differ in mechanism, half-life (~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation) vs 5-8 hours (plasma); central CNS effect 10-16 hours), and typical dose range.
Which has the longer half-life, Selank or Phenibut?
Selank has a half-life of ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation). Phenibut has a half-life of 5-8 hours (plasma); central CNS effect 10-16 hours. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Can you stack Selank and Phenibut?
Stacking depends on mechanism overlap, safety profile, and goals. Selank and Phenibut should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Research use only. BodyHackGuide is an independent research reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks — this never affects the data or pricing shown. See editorial standards and affiliate disclosure.