DSIP (Delta Sleep-Inducing Peptide) vs Epithalon
Side-by-side comparison of DSIP (Delta Sleep-Inducing Peptide) and Epithalon: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
DSIP (Delta Sleep-Inducing Peptide)
Epithalon
DSIP (Delta Sleep-Inducing Peptide)
Delta sleep-inducing peptide (DSIP) is a nonapeptide — a 9-amino-acid neuropeptide with sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE, 848 Da molecular weight) — first isolated in 1977 from the cerebral venous…
Lowest listed price: $34.99 across 11 listings
Full DSIP (Delta Sleep-Inducing Peptide) profileEpithalon
Epithalon (also spelled Epitalon, sequence Ala-Glu-Asp-Gly / AEDG) is a synthetic tetrapeptide designed by Prof. Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology in the 1980s as a…
Lowest listed price: $34.99 across 4 listings
Full Epithalon profileSide-by-side comparison
| Attribute | DSIP (Delta Sleep-Inducing Peptide) | Epithalon |
|---|---|---|
| Category | Cognition, Mood & Neuroprotection | Longevity & Cellular Health |
| Research Stage | Research Use Only | Preclinical (Western standards); Used clinically in Russian gerontological medicine |
| Mechanism of Action | Primary Mechanism: Uncharacterized Direct Receptor Binding After more than four decades of research, DSIP's primary molecular target remains unknown. No specific receptor has been cloned, characterized, or reproducibly identified as the primary binding site… | Epithalon (AEDG; Ala-Glu-Asp-Gly) is a synthetic tetrapeptide modeled on the pineal polypeptide preparation epithalamin. Its proposed mechanism spans several parallel pathways. The human-relevant evidence is strongest for melatonin/circadian effects; the… |
| Half-Life | ~7-15 minutes (IV; plasma clearance is rapid, though subjective sleep effects can outlast measurable blood levels) | Not well characterized in humans. As a small tetrapeptide, AEDG is expected to have a very short plasma half-life (on the order of minutes), while downstream gene-expression and circadian effects are thought to persist considerably longer. Any specific half-life figure should be treated as an unvalidated estimate. |
| Typical Dose Range | 100–300 mcg per injection | 5000-10000 mcg (5-10 mg) subcutaneous daily for 10-20 day cycles; typically repeated 1-2 times per year in anti-aging protocols |
| Dosing Frequency | Once daily, 30–60 minutes before bedtime | Once daily for 10–20 day cycles |
| Administration | Subcutaneous, Intramuscular, Intranasal | Subcutaneous |
| Side Effects | Overall Safety Profile DSIP has one of the cleanest safety profiles of any peptide in the research chemical space. In 40+ years of research and clinical use, no serious adverse events have been reported in controlled trials or large case series. The compound… | Expected / benign - Mild injection-site reaction — redness, slight tenderness, occasional small bruise. Resolves within 24-48 hours. - Enhanced, more vivid dreams in the first week of a cycle — consistent with melatonin rise. - Deeper sleep onset and feeling… |
| Molecular Weight | 848.8 Da | 390.3 Da |
| Common Vial Sizes | 2mg, 5mg | 10mg, 50mg |
Price History
8 data points- BM
- Half Nattys
- LB
- Ion Peptide
- OF
- Disguised Alpha
- BHG Labs
Price History
3 data points- Half Nattys
- Disguised Alpha
- LB
DSIP (Delta Sleep-Inducing Peptide): potential benefits
- Sleep quality support
- Stress reduction
- Cortisol/HPA modulation
- Alcohol & opioid withdrawal support
- Circadian regulation
Epithalon: potential benefits
- Telomerase activation and telomere elongation (human cell culture)
- Normalization of circadian melatonin rhythm (human data from epithalamin, the parent pineal preparation)
- Improved sleep consolidation and circadian regularity (subjective)
- Modest life-span effects in rodents (mainly maximum / late-survivor lifespan; no change in mean lifespan)
- Reduced incidence of specific tumors (e.g. ~6-fold fewer leukemias in SHR mice); no change in total tumor incidence
- Reduced chromosomal aberrations in aged rodent tissue
- Site-specific DNA / chromatin binding (proposed epigenetic modulation)
- Association with lower mortality in an elderly cardiovascular cohort (epithalamin RCT, Korkushko 2011)
Frequently asked
What's the difference between DSIP (Delta Sleep-Inducing Peptide) and Epithalon?
DSIP (Delta Sleep-Inducing Peptide) is a cognition, mood & neuroprotection that primary mechanism: uncharacterized direct receptor binding after more than four decades of research, dsip's primary molecular target remains unknown. no specific receptor has been…. Epithalon is a longevity & cellular health that epithalon (aedg; ala-glu-asp-gly) is a synthetic tetrapeptide modeled on the pineal polypeptide preparation epithalamin. its proposed mechanism spans several parallel pathways. the…. The two differ in mechanism, half-life (~7-15 minutes (IV; plasma clearance is rapid, though subjective sleep effects can outlast measurable blood levels) vs Not well characterized in humans. As a small tetrapeptide, AEDG is expected to have a very short plasma half-life (on the order of minutes), while downstream gene-expression and circadian effects are thought to persist considerably longer. Any specific half-life figure should be treated as an unvalidated estimate.), and typical dose range.
Which has the longer half-life, DSIP (Delta Sleep-Inducing Peptide) or Epithalon?
DSIP (Delta Sleep-Inducing Peptide) has a half-life of ~7-15 minutes (IV; plasma clearance is rapid, though subjective sleep effects can outlast measurable blood levels). Epithalon has a half-life of Not well characterized in humans. As a small tetrapeptide, AEDG is expected to have a very short plasma half-life (on the order of minutes), while downstream gene-expression and circadian effects are thought to persist considerably longer. Any specific half-life figure should be treated as an unvalidated estimate.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, DSIP (Delta Sleep-Inducing Peptide) or Epithalon?
Lowest listed price on BodyHackGuide: DSIP (Delta Sleep-Inducing Peptide) from $34.99, Epithalon from $34.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack DSIP (Delta Sleep-Inducing Peptide) and Epithalon?
Stacking depends on mechanism overlap, safety profile, and goals. DSIP (Delta Sleep-Inducing Peptide) and Epithalon should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.