BPC-157/TB-500 Blend vs BPC-157
Side-by-side comparison of BPC-157/TB-500 Blend and BPC-157: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
BPC-157/TB-500 Blend
BPC-157
BPC-157/TB-500 Blend
Combined healing peptide blend
Lowest listed price: $49.99 across 6 listings
Full BPC-157/TB-500 Blend profileBPC-157
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide consisting of 15 amino acids (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) derived from a partial sequence of human gastric juice…
Lowest listed price: $34.99 across 15 listings
Full BPC-157 profileSide-by-side comparison
| Attribute | BPC-157/TB-500 Blend | BPC-157 |
|---|---|---|
| Category | Recovery | Injury, Repair & Recovery |
| Research Stage | Preclinical | Preclinical |
| Mechanism of Action | A combination of BPC-157 and TB-500 (thymosin beta-4) in a single formulation. It pairs BPC-157's angiogenic, pro-healing activity - driven largely through VEGFR2 and nitric-oxide (Akt-eNOS) signaling (PMID: 40789979) - with TB-500's actin… | Nitric Oxide (NO) System Modulation BPC-157 exerts a central integrative effect through modulation of the nitric oxide system. Studies by Seiwerth et al. (2022) demonstrated that BPC-157 counteracts both NO-excess and NO-deficiency states, functioning as a… |
| Half-Life | BPC-157: short - under ~30 min in animal PK studies (rats/dogs); no human PK data. TB-500 (thymosin beta-4): active fragment ~30 min, though tissue effects are prolonged. | Short plasma half-life. The first formal preclinical ADME study reported an elimination half-life under ~30 minutes after IV/IM dosing in rats and dogs, with linear dose-proportional kinetics (PMID: 36588717); a 2026 biopharmaceutical review confirms this sub-30-minute plasma half-life and highlights a pharmacokinetic-pharmacodynamic disconnect, as biological effects persist for hours to days (PMID: 42198317). No full human pharmacokinetic study has been published; twice-daily dosing is empirical/community-standard rather than PK-derived. |
| Typical Dose Range | Dosed per component (a fixed daily blend over-doses TB-500 - see notes). BPC-157: 250-500 mcg once daily SUBQ. TB-500 (thymosin beta-4): 2-2.5 mg twice weekly during a 4-6 week loading phase, then 2-2.5 mg once weekly for maintenance (~5 mg/week during loading). If a pre-blended fixed-ratio daily vial is used, its TB-500 fraction should be ~250-350 mcg per injection so the weekly TB-500 total stays near ~5 mg. | 200-500 mcg subcutaneous 1-2x daily (community protocols); 1-10 mcg/kg in animal studies |
| Dosing Frequency | BPC-157: once daily SUBQ. TB-500: twice weekly during the loading phase, then maintenance ~2-3x/week or once weekly for TB-500 as needed. | Twice daily (AM and PM) for optimal serum levels; once daily acceptable |
| Administration | Subcutaneous, Intramuscular | Subcutaneous, Oral, Intraperitoneal, Intravenous |
| Side Effects | See individual compounds. Generally well-tolerated. Injection site reactions, mild nausea, headache. Rare: temporary fatigue. | Generally well-tolerated. Mild nausea or GI discomfort during initial use. Temporary increase in pain/inflammation at injury site (healing response). Rare: drowsiness, dizziness, mild headache. Very rare: transient changes in blood pressure. |
| Molecular Weight | BPC-157: ~1419.5 g/mol (average; molecular formula C62H98N16O22). TB-500 (thymosin beta-4): ~4963 Da (full 43-residue peptide). | 1419.5 g/mol (average); molecular formula C62H98N16O22 |
| Common Vial Sizes | 5mg, 10mg | 5mg, 10mg |
Price History
4 data points- OF
- BM
- Half Nattys
- BHG Labs
- RC
Price History
7 data points- OF
- BM
- Half Nattys
- LB
- Ion Peptide
- BHG Labs
BPC-157/TB-500 Blend: potential benefits
- Accelerated tissue healing (preclinical/anecdotal)
- Reduced recovery time
- Anti-inflammatory support
- Complementary repair mechanisms: angiogenesis (BPC-157) plus actin-regulated cell migration (TB-500)
BPC-157: potential benefits
- Accelerated tendon and ligament healing with improved biomechanical strength in preclinical soft-tissue injury models (PMID: 30915550)
- Gastric and GI mucosal cytoprotection against ethanol-induced lesions, mediated in part by the nitric oxide system (PMID: 30279308)
- Healing of cysteamine-induced colitis and colon anastomosis in preclinical inflammatory bowel disease models (PMID: 24304574)
- Neuroprotection with dopaminergic and nitric oxide-system modulation in central nervous system injury models such as stroke and dopamine-receptor blockade (PMID: 34380875)
- Promotion of angiogenesis via VEGFR2 up-regulation, internalization, and VEGFR2-Akt-eNOS signaling in rat hind-limb ischemia and endothelial assays (PMID: 27847966)
- Tendon fibroblast outgrowth, cell survival, and migration through FAK-paxillin pathway activation (PMID: 21030672)
- Growth hormone receptor up-regulation in tendon fibroblasts, potentiating growth hormone's proliferative effect (PMID: 25415472)
- Nitric oxide-system interaction with endothelium protection, angiogenesis, and EGR-1-mediated growth-factor and collagen expression (PMID: 22300085)
Frequently asked
What's the difference between BPC-157/TB-500 Blend and BPC-157?
BPC-157/TB-500 Blend is a recovery that a combination of bpc-157 and tb-500 (thymosin beta-4) in a single formulation. it pairs bpc-157's angiogenic, pro-healing activity - driven largely through vegfr2 and nitric-oxide…. BPC-157 is a injury, repair & recovery that nitric oxide (no) system modulation bpc-157 exerts a central integrative effect through modulation of the nitric oxide system. studies by seiwerth et al. (2022) demonstrated that…. The two differ in mechanism, half-life (BPC-157: short - under ~30 min in animal PK studies (rats/dogs); no human PK data. TB-500 (thymosin beta-4): active fragment ~30 min, though tissue effects are prolonged. vs Short plasma half-life. The first formal preclinical ADME study reported an elimination half-life under ~30 minutes after IV/IM dosing in rats and dogs, with linear dose-proportional kinetics (PMID: 36588717); a 2026 biopharmaceutical review confirms this sub-30-minute plasma half-life and highlights a pharmacokinetic-pharmacodynamic disconnect, as biological effects persist for hours to days (PMID: 42198317). No full human pharmacokinetic study has been published; twice-daily dosing is empirical/community-standard rather than PK-derived.), and typical dose range.
Which has the longer half-life, BPC-157/TB-500 Blend or BPC-157?
BPC-157/TB-500 Blend has a half-life of BPC-157: short - under ~30 min in animal PK studies (rats/dogs); no human PK data. TB-500 (thymosin beta-4): active fragment ~30 min, though tissue effects are prolonged.. BPC-157 has a half-life of Short plasma half-life. The first formal preclinical ADME study reported an elimination half-life under ~30 minutes after IV/IM dosing in rats and dogs, with linear dose-proportional kinetics (PMID: 36588717); a 2026 biopharmaceutical review confirms this sub-30-minute plasma half-life and highlights a pharmacokinetic-pharmacodynamic disconnect, as biological effects persist for hours to days (PMID: 42198317). No full human pharmacokinetic study has been published; twice-daily dosing is empirical/community-standard rather than PK-derived.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, BPC-157/TB-500 Blend or BPC-157?
Lowest listed price on BodyHackGuide: BPC-157/TB-500 Blend from $49.99, BPC-157 from $34.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack BPC-157/TB-500 Blend and BPC-157?
Stacking depends on mechanism overlap, safety profile, and goals. BPC-157/TB-500 Blend and BPC-157 should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
See current vendor prices
Listings from the vendors we track. Prices change often, so check the vendor before you buy.
Before you buy BPC-157/TB-500 Blend or BPC-157
Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor.
Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.