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    PerformancePhase 3

    Ostarine (Enobosarm, MK-2866) Dosage Guide: Protocols, Calculator & Safety

    Everything you need to know about Ostarine (Enobosarm, MK-2866) dosing: protocols, safety, and where to buy.

    Half-Life

    Not established from a retrieved human report; in rats the mean elimination half-life of radiolabeled GTx-024 was 0.6 h in males and 16.4 h in females (PMID: 24074268). Human plasma pharmacokinetics were characterized in phase 1 drug-interaction studies (PMID: 27105861)

    Administration Routes

    Oral

    Dosage Calculator

    Calculate exact dosing for Ostarine (Enobosarm, MK-2866).

    Dosing data for Ostarine (Enobosarm, MK-2866) is being researched. Check the compound page for the latest information.

    Side Effects & Safety

    Published human case reports describe cholestatic and hepatocellular drug-induced liver injury after ostarine use, including severe jaundice needing albumin dialysis with recovery over roughly six months (PMID: 37871633), a hepatocellular case that resolved on stopping (PMID: 35655632), and cases where ostarine was combined with post-cycle drugs (PMID: 34141767). A systematic review of SARM safety in healthy adults found fifteen published drug-induced liver injury cases across the class plus one Achilles tendon rupture and one rhabdomyolysis case, and reported raised alanine aminotransferase in about 7 percent of trial participants exposed to a SARM (PMID: 37218811). In the phase 2 breast cancer trial, grade 3 or 4 drug-related events included raised hepatic transaminases, hypercalcemia and fatigue (PMID: 38342115). In cultured cardiomyocytes ostarine showed sex-specific cytotoxicity (PMID: 37543162).

    Contraindications

    Mechanism-based: androgen receptor agonists are contraindicated in pregnancy because of the risk of virilizing a female fetus, and in men with known or suspected prostate cancer, since androgen receptor activation can drive prostate tissue. Existing liver disease or raised transaminases is a mechanism-based and case-report-based reason to avoid it, given published cholestatic and hepatocellular injury (PMID: 37871633, PMID: 35655632). Athletes in tested sport must avoid it because it is prohibited at all times (PMID: 38499138).

    Check interactions with the Interaction Checker →

    Frequently Asked Questions

    What is the recommended Ostarine (Enobosarm, MK-2866) dosage?

    Dosage for Ostarine (Enobosarm, MK-2866) varies by protocol. Consult a qualified healthcare provider.

    How often should I take Ostarine (Enobosarm, MK-2866)?

    Administration frequency depends on the specific protocol. Consult current research literature.

    Does Ostarine (Enobosarm, MK-2866) need to be cycled?

    Cycling requirements depend on the protocol. Follow established research guidelines.

    What are Ostarine (Enobosarm, MK-2866) side effects?

    Published human case reports describe cholestatic and hepatocellular drug-induced liver injury after ostarine use, including severe jaundice needing albumin dialysis with recovery over roughly six months (PMID: 37871633), a hepatocellular case that resolved on stopping (PMID: 35655632), and cases where ostarine was combined with post-cycle drugs (PMID: 34141767). A systematic review of SARM safety in healthy adults found fifteen published drug-induced liver injury cases across the class plus one Achilles tendon rupture and one rhabdomyolysis case, and reported raised alanine aminotransferase in about 7 percent of trial participants exposed to a SARM (PMID: 37218811). In the phase 2 breast cancer trial, grade 3 or 4 drug-related events included raised hepatic transaminases, hypercalcemia and fatigue (PMID: 38342115). In cultured cardiomyocytes ostarine showed sex-specific cytotoxicity (PMID: 37543162).

    Where can I buy Ostarine (Enobosarm, MK-2866)?

    Compare 1 listings from 1 vendor on our price comparison page, starting from $74.99.

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