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    $19.50/mg· $39.00 for 2mg at Ion Peptide

    PEG-MGF

    PerformancePreclinical

    Also known as: Pegylated Mechano Growth Factor, PEGylated IGF-1 Ec, MGF, Mechano Growth Factor, IGF-1 splice variant

    PEG-MGF (Pegylated Mechano Growth Factor) is a synthetic, PEGylated form of Mechano Growth Factor (MGF) — an alternatively spliced variant of IGF-1 produced locally in muscle and other tissues in response to mechanical loading or damage. MGF differs from systemic IGF-1 in that it has a unique E-domain peptide (the Ec peptide, or MGF peptide) that activates satellite cells (muscle stem cells) rather than IGF-1 receptor signaling.

    Half-Life: Native MGF: very short (minutes) due to rapid proteolysis. PEG-MGF: PEGylation is intended to extend this substantially (community estimates up to roughly 1 day), but there are no published human pharmacokinetic data to confirm a specific value.Route: Subcutaneous, Intramuscular, IntravenousMW: Free MGF 24-aa peptide: approximately 2,867-2,868 Da (reported molecular formula ~C121H199N41O40). PEG-MGF is heavier: the conjugated polyethylene glycol adds a variable mass (commonly a few kDa) on top of the peptide, so total mass depends on the PEG used.
    Last reviewed:
    Performance
    Category
    Preclinical
    Research Stage

    Overview

    Best Price Available

    Ion Peptide logo

    Ion Peptide

    $39.00

    1 vial · vial

    At A Glance

    Mechanism

    PEG-MGF is the PEGylated form of Mechano Growth Factor (MGF), a synthetic peptide corresponding to the C-terminal 24 amino acids of the unique E-domain of IGF-1Ec, an alternatively spliced variant of the IGF-1 gene expressed in skeletal muscle after mechanical loading or damage. …

    Half-Life
    Native MGF: very short (minutes) due to rapid proteolysis. PEG-MGF: PEGylation is intended to extend this substantially (community estimates up to roughly 1 day), but there are no published human pharmacokinetic data to confirm a specific value.
    Dosing
    twice weekly
    Dose Range
    200mcg
    Routes
    SubcutaneousIntramuscularIntravenous
    Common Vials
    2mg
    Potential Benefits
    Increases satellite-cell and myoblast proliferation, expanding the cell pool available for muscle repair (in vitro and animal studies)May accelerate muscle repair after exercise-induced damage or injury (preclinical)Pro-survival, anti-apoptotic signaling reported in muscle and other cell types (preclinical)Preclinical cytoprotection: MGF pretreatment improved cardiac function after experimental myocardial infarction (mechanism distinct from IGF-1R, NOT via fibroblast growth factor receptor)Preclinical neuroprotection during cerebral ischemiaPEGylation is intended to extend native MGF's very short half-life to allow less frequent research dosing
    Safety Notes
    Common
    Injection-site reactions (redness, itching, swelling)Post-injection fatigue or lethargy (anecdotal)No controlled human data - tolerability is not established
    Serious
    No controlled human safety data of any kindTheoretical mitogenic/proliferative risk - MGF is a proliferation-promoting growth-factor peptide; caution in anyone with active or prior malignancyUnlike IGF-1 or IGF-1 LR3, the MGF E-peptide signals through a non-IGF-1R receptor and is not expected to cause classic insulin-like hypoglycemia, but its metabolic effects in humans are unknownWADA prohibited: S2 category (peptide hormones, growth factors and mimetics)

    Overview

    PEG-MGF (Pegylated Mechano Growth Factor) is a synthetic, PEGylated form of Mechano Growth Factor (MGF) — an alternatively spliced variant of IGF-1 produced locally in muscle and other tissues in response to mechanical loading or damage. MGF differs from systemic IGF-1 in that it has a unique E-domain peptide (the Ec peptide, or MGF peptide) that activates satellite cells (muscle stem cells) rather than IGF-1 receptor signaling. Pegylation (attachment of polyethylene glycol chains) dramatically extends MGF's plasma half-life from minutes to approximately 24 hours, enabling systemic administration in research protocols. PEG-MGF is researched primarily for its muscle satellite cell activation, tissue repair, and recovery applications.

    Chemical Information

    IUPAC Name

    Not yet available

    CAS Number

    Not yet available

    Molecular Formula

    Not yet available

    Molecular Mass

    Free peptide approximately 2,867-2,868 Da (24-aa MGF E-peptide). The total mass of PEG-MGF is greater and is not standardized - it depends on the size of the attached PEG chain.

    Amino Acid Sequence

    YQPPSTNKNTKSQRRKGSTFEERK - the human MGF / IGF-1Ec C-terminal 24-amino-acid E-domain peptide (Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys). PEG-MGF is this same peptide covalently conjugated to a polyethylene glycol (PEG) moiety to slow proteolytic degradation.

    Dosing & Protocols

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    Interactions

    Interaction and contraindication data is being compiled for PEG-MGF. Check back soon.

    General Safety Note

    Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented.

    Best Price

    $39.00

    Best $/mg

    $19.5000

    Vendors

    1

    Listings

    1

    vial

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    Ion Peptide
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    🇺🇸US🌍International
    		 PEG-MGF 2mg vial 1 vial● In Stock $39.00BEST $19.500 —

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    Current low
    $39.00
    as of Apr 22, 2026
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    baseline building

    Tracking since Apr 22, 2026 · 1 data point

    Vendors Selling PEG-MGF

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    ITPP

    PerformancePreclinical

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    Research compound — IV infusion in studies, no established oral doses
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    SLU-PP-332

    PerformancePreclinical

    SLU-PP-332 is the first-generation synthetic pan-agonist of the estrogen-related receptors (ERRα, ERRβ, ERRγ) developed by the laboratory of Thomas Burris at Saint Louis University and reported in a landmark 2023 publication that established ERR pan-agonism as a pharmacologically tractable exercise-mimetic drug mechanism.

    Research compound — no established human doses. Animal studies: 10-50 mg/kg
    8 studiesView Profile

    View Full Dosage Guide →

    Protocols, calculator & safety for PEG-MGF

    Best Price

    Ion Peptide logo

    Ion Peptide

    $39.00

    1 vendors · 1 listings

    Research Score

    45

    0 PubMed studies

    Quality Indicators

    Data Completeness

    63%
    Description
    Mechanism of Action
    Chemical Data
    Dosing Protocols
    Safety Profile
    PubMed Studies
    Interactions
    Vendor Listings

    Quick Facts

    Half-Life

    Native MGF: very short (minutes) due to rapid proteolysis. PEG-MGF: PEGylation is intended to extend this substantially (community estimates up to roughly 1 day), but there are no published human pharmacokinetic data to confirm a specific value.

    Molecular Weight

    Free peptide approximately 2,867-2,868 Da (24-aa MGF E-peptide). The total mass of PEG-MGF is greater and is not standardized - it depends on the size of the attached PEG chain.

    Administration

    Subcutaneous, Intramuscular, Intravenous

    Trial Phase

    Preclinical

    Safety Profile

    Common Side Effects

    • • Injection-site reactions (redness, itching, swelling)
    • • Post-injection fatigue or lethargy (anecdotal)
    • • No controlled human data - tolerability is not established

    Research Disclaimer

    This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.

    Frequently Asked Questions

    What is PEG-MGF used for in research?

    PEG-MGF (Pegylated Mechano Growth Factor) is a synthetic, PEGylated form of Mechano Growth Factor (MGF) — an alternatively spliced variant of IGF-1 produced locally in muscle and other tissues in response to mechanical loading or damage. MGF differs from systemic IGF-1 in that it has a unique E-domain peptide (the Ec peptide, or MGF peptide) that activates satellite cells (muscle stem cells) rather than IGF-1 receptor signaling. Pegylation (attachment of polyethylene glycol chains) dramatically extends MGF's plasma half-life from minutes to approximately 24 hours, enabling systemic administration in research protocols. PEG-MGF is researched primarily for its muscle satellite cell activation, tissue repair, and recovery applications.

    What forms does PEG-MGF come in?

    PEG-MGF is available in vial form.

    How much does PEG-MGF cost?

    Prices start at $39.00 across 1 verified vendor.

    How do I compare PEG-MGF vendors?

    Compare prices, payment methods, shipping, and COA scores across 1 vendor.

    Research Tools

    Related Compounds

    View All

    ITPP

    PerformancePreclinical

    ITPP (myo-inositol trispyrophosphate, sometimes written myo-inositol tripyrophosphate or OXY111A in NormOxys trial documents) is a small-molecule allosteric effector of hemoglobin designed to increase the amount of oxygen red blood cells release to tissues.

    Research compound — IV infusion in studies, no established oral doses
    36 studiesView Profile

    SLU-PP-332

    PerformancePreclinical

    SLU-PP-332 is the first-generation synthetic pan-agonist of the estrogen-related receptors (ERRα, ERRβ, ERRγ) developed by the laboratory of Thomas Burris at Saint Louis University and reported in a landmark 2023 publication that established ERR pan-agonism as a pharmacologically tractable exercise-mimetic drug mechanism.

    Research compound — no established human doses. Animal studies: 10-50 mg/kg
    8 studiesView Profile

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