PEG-MGF
PerformancePreclinicalAlso known as: Pegylated Mechano Growth Factor, PEGylated IGF-1 Ec, MGF, Mechano Growth Factor, IGF-1 splice variant
PEG-MGF (Pegylated Mechano Growth Factor) is a synthetic, PEGylated form of Mechano Growth Factor (MGF) — an alternatively spliced variant of IGF-1 produced locally in muscle and other tissues in response to mechanical loading or damage. MGF differs from systemic IGF-1 in that it has a unique E-domain peptide (the Ec peptide, or MGF peptide) that activates satellite cells (muscle stem cells) rather than IGF-1 receptor signaling.
Overview
At A Glance
PEG-MGF's unique Ec-domain peptide activates muscle satellite cells (Pax7+/MyoD+ cells) independently of IGF-1R signaling. This drives satellite cell proliferation and differentiation — the primary mechanism for adding new myonuclei to existing muscle fibers (myonuclear accretion…
Overview
PEG-MGF (Pegylated Mechano Growth Factor) is a synthetic, PEGylated form of Mechano Growth Factor (MGF) — an alternatively spliced variant of IGF-1 produced locally in muscle and other tissues in response to mechanical loading or damage. MGF differs from systemic IGF-1 in that it has a unique E-domain peptide (the Ec peptide, or MGF peptide) that activates satellite cells (muscle stem cells) rather than IGF-1 receptor signaling. Pegylation (attachment of polyethylene glycol chains) dramatically extends MGF's plasma half-life from minutes to approximately 24 hours, enabling systemic administration in research protocols. PEG-MGF is researched primarily for its muscle satellite cell activation, tissue repair, and recovery applications.
Chemical Information
IUPAC Name
Not yet available
CAS Number
Not yet available
Molecular Formula
Not yet available
Molecular Mass
Not yet available
Chemical data is being compiled for this compound.
Dosing & Protocols
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Research
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Interactions
Interaction and contraindication data is being compiled for PEG-MGF. Check back soon.
General Safety Note
Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented.
$39.00
$19.5000
1
1
vial
Tracking since Apr 22, 2026 · 1 data point
Vendors Selling PEG-MGF
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Related Compounds
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SLU-PP-332
PerformancePreclinicalSLU-PP-332 is the first-generation synthetic pan-agonist of the estrogen-related receptors (ERRα, ERRβ, ERRγ) developed by the laboratory of Thomas Burris at Saint Louis University and reported in a landmark 2023 publication that established ERR pan-agonism as a pharmacologically tractable exercise-mimetic drug mechanism.
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Protocols, calculator & safety for PEG-MGF
Research Score
0 PubMed studies
Quality Indicators
Data Completeness
63%Quick Facts
Half-Life
~24 hours (PEGylated form; native MGF: <30 minutes)
Administration
Subcutaneous, Intramuscular, Intravenous
Trial Phase
Preclinical
Safety Profile
Common Side Effects
- • Injection site reactions
- • Mild transient hypoglycemia (IGF-1 pathway activity)
- • Fatigue post-injection
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is PEG-MGF used for in research?
PEG-MGF (Pegylated Mechano Growth Factor) is a synthetic, PEGylated form of Mechano Growth Factor (MGF) — an alternatively spliced variant of IGF-1 produced locally in muscle and other tissues in response to mechanical loading or damage. MGF differs from systemic IGF-1 in that it has a unique E-domain peptide (the Ec peptide, or MGF peptide) that activates satellite cells (muscle stem cells) rather than IGF-1 receptor signaling. Pegylation (attachment of polyethylene glycol chains) dramatically extends MGF's plasma half-life from minutes to approximately 24 hours, enabling systemic administration in research protocols. PEG-MGF is researched primarily for its muscle satellite cell activation, tissue repair, and recovery applications.
What forms does PEG-MGF come in?
PEG-MGF is available in vial form.
How much does PEG-MGF cost?
Prices start at $39.00 across 1 verified vendor.
How do I compare PEG-MGF vendors?
Compare prices, payment methods, shipping, and COA scores across 1 vendor.
Research Tools
Related Compounds
View AllITPP
PerformancePreclinicalITPP (myo-inositol trispyrophosphate, sometimes written myo-inositol tripyrophosphate or OXY111A in NormOxys trial documents) is a small-molecule allosteric effector of hemoglobin designed to increase the amount of oxygen red blood cells release to tissues.
SLU-PP-332
PerformancePreclinicalSLU-PP-332 is the first-generation synthetic pan-agonist of the estrogen-related receptors (ERRα, ERRβ, ERRγ) developed by the laboratory of Thomas Burris at Saint Louis University and reported in a landmark 2023 publication that established ERR pan-agonism as a pharmacologically tractable exercise-mimetic drug mechanism.
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