Also known as: Pegylated Mechano Growth Factor, PEGylated IGF-1 Ec, MGF, Mechano Growth Factor, IGF-1 splice variant
PEG-MGF (Pegylated Mechano Growth Factor) is a synthetic, PEGylated form of Mechano Growth Factor (MGF) — an alternatively spliced variant of IGF-1 produced locally in muscle and other tissues in response to mechanical loading or damage. MGF differs from systemic IGF-1 in that it has a unique E-domain peptide (the Ec peptide, or MGF peptide) that activates satellite cells (muscle stem cells) rather than IGF-1 receptor signaling.
Overview
At A Glance
PEG-MGF is the PEGylated form of Mechano Growth Factor (MGF), a synthetic peptide corresponding to the C-terminal 24 amino acids of the unique E-domain of IGF-1Ec, an alternatively spliced variant of the IGF-1 gene expressed in skeletal muscle after mechanical loading or damage. …
Overview
PEG-MGF (Pegylated Mechano Growth Factor) is a synthetic, PEGylated form of Mechano Growth Factor (MGF) — an alternatively spliced variant of IGF-1 produced locally in muscle and other tissues in response to mechanical loading or damage. MGF differs from systemic IGF-1 in that it has a unique E-domain peptide (the Ec peptide, or MGF peptide) that activates satellite cells (muscle stem cells) rather than IGF-1 receptor signaling. Pegylation (attachment of polyethylene glycol chains) dramatically extends MGF's plasma half-life from minutes to approximately 24 hours, enabling systemic administration in research protocols. PEG-MGF is researched primarily for its muscle satellite cell activation, tissue repair, and recovery applications.
Chemical Information
IUPAC Name
Not yet available
CAS Number
Not yet available
Molecular Formula
Not yet available
Molecular Mass
Free peptide approximately 2,867-2,868 Da (24-aa MGF E-peptide). The total mass of PEG-MGF is greater and is not standardized - it depends on the size of the attached PEG chain.
Amino Acid Sequence
Dosing & Protocols
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Research
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Interactions
Interaction and contraindication data is being compiled for PEG-MGF. Check back soon.
General Safety Note
Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented.
$39.00
$19.5000
1
1
vial
Tracking since Apr 22, 2026 · 1 data point
Vendors Selling PEG-MGF
How we score these vendors
Every supplier above is graded 0 to 100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank.
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Protocols, calculator & safety for PEG-MGF
Research Score
0 PubMed results
Quality Indicators
Data Completeness
63%Quick Facts
Half-Life
Native MGF: very short (minutes) due to rapid proteolysis. PEG-MGF: PEGylation is intended to extend this substantially (community estimates up to roughly 1 day), but there are no published human pharmacokinetic data to confirm a specific value.
Molecular Weight
Free peptide approximately 2,867-2,868 Da (24-aa MGF E-peptide). The total mass of PEG-MGF is greater and is not standardized - it depends on the size of the attached PEG chain.
Administration
Subcutaneous, Intramuscular, Intravenous
Trial Phase
Preclinical
Safety Profile
Common Side Effects
- • Injection-site reactions (redness, itching, swelling)
- • Post-injection fatigue or lethargy (anecdotal)
- • No controlled human data - tolerability is not established
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is PEG-MGF used for in research?
PEG-MGF (Pegylated Mechano Growth Factor) is a synthetic, PEGylated form of Mechano Growth Factor (MGF) — an alternatively spliced variant of IGF-1 produced locally in muscle and other tissues in response to mechanical loading or damage. MGF differs from systemic IGF-1 in that it has a unique E-domain peptide (the Ec peptide, or MGF peptide) that activates satellite cells (muscle stem cells) rather than IGF-1 receptor signaling. Pegylation (attachment of polyethylene glycol chains) dramatically extends MGF's plasma half-life from minutes to approximately 24 hours, enabling systemic administration in research protocols. PEG-MGF is researched primarily for its muscle satellite cell activation, tissue repair, and recovery applications.
What forms does PEG-MGF come in?
PEG-MGF is available in vial form.
How do I compare PEG-MGF vendors?
Compare prices, payment methods, shipping, and COA scores across 1 vendor.
How many vendors sell PEG-MGF, and what does it cost per mg?
1 of the vendors BodyHackGuide tracks list PEG-MGF (1 listing). Among BodyHackGuide's PEG-MGF listings recorded as in stock with a milligram count, the lowest price per milligram is $19.50/mg at Ion Peptide and the median is $19.50/mg. The PEG-MGF prices on BodyHackGuide are vendors' listed prices as BodyHackGuide last recorded them, not transactions; the most recent recorded change to a PEG-MGF listing is dated 22 April 2026.
Which vendors have third-party COAs for PEG-MGF on file at BodyHackGuide?
BodyHackGuide holds 5 third-party certificate records for PEG-MGF, from . No editor has read any of BodyHackGuide's 5 certificate records for PEG-MGF. The laboratory named on BodyHackGuide's PEG-MGF certificate records is Freedom Diagnostics Testing, and the newest test date on them is 18 September 2025. Each vendor page on BodyHackGuide shows how many certificate records BodyHackGuide holds for that vendor and links to each record that has its own page.
Research Tools
Related Compounds
View AllITPP
PerformancePreclinicalITPP (myo-inositol trispyrophosphate, sometimes written myo-inositol tripyrophosphate or OXY111A in NormOxys trial documents) is a small-molecule allosteric effector of hemoglobin designed to increase the amount of oxygen red blood cells release to tissues.
LGD-4033 (Ligandrol)
PerformancePhase 2LGD-4033, usually sold as ligandrol, is a nonsteroidal selective androgen receptor modulator that Viking Therapeutics took into clinical development under the code VK5211 (NCT02578095).
Ostarine (Enobosarm, MK-2866)
PerformancePhase 3Ostarine is the market name for enobosarm, a nonsteroidal selective androgen receptor modulator first developed by GTx Inc under the codes GTx-024, MK-2866 and S-22.
RAD-140 (Testolone)
PerformancePhase 1RAD-140, sold as testolone and given the international nonproprietary name vosilasarm, is a nonsteroidal selective androgen receptor modulator developed at Radius Health, whose scientists reported the first-in-human trial (PMID: 34565686), and first described in the medicinal chemistry literature as a compound with an oxadiazole core designed for oral androgen receptor activity with tissue selectivity (PMID: 24900290).
SLU-PP-332
PerformancePreclinicalSLU-PP-332 is the first-generation synthetic pan-agonist of the estrogen-related receptors (ERRα, ERRβ, ERRγ) developed by the laboratory of Thomas Burris at Saint Louis University and reported in a landmark 2023 publication that established ERR pan-agonism as a pharmacologically tractable exercise-mimetic drug mechanism.
YK-11
PerformancePreclinicalYK-11 is a synthetic steroid, not a nonsteroidal SARM, despite being sold alongside them.
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