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    TAK-653

    NootropicsPhase II Clinical Trials

    TAK-653 is a novel positive allosteric modulator (PAM) of AMPA-type glutamate receptors developed by Takeda Pharmaceuticals. It enhances glutamatergic neurotransmission without directly activating the receptor, offering a more controlled mechanism for cognitive enhancement and antidepressant effects.

    BHG Labs logo

    Lowest price

    $79.991 bottle

    at BHG Labs

    Half-life: 6-10 hours (estimated)Route: OralMW: 282.27CAS: 1531665-83-2
    Last reviewed:

    Overview

    At A Glance

    Mechanism

    TAK-653 acts as a positive allosteric modulator (PAM) of AMPA receptors, binding to a site distinct from the glutamate binding site. It increases the receptor's sensitivity to glutamate, improving excitatory postsynaptic currents (EPSCs) and promoting long-term potentiation (LTP)…

    Half-Life
    6-10 hours (estimated)
    Dosing
    Once daily
    Dose Range
    0.1 mg - 6 mg
    Routes
    Oral
    Potential Benefits
    Cognitive enhancement and improved learningAntidepressant effects (treatment-resistant depression)Enhanced synaptic plasticity and LTPIncreased BDNF expressionImproved working memory and executive functionPotential neuroprotective properties

    Overview

    TAK-653 is a novel positive allosteric modulator (PAM) of AMPA-type glutamate receptors developed by Takeda Pharmaceuticals. It enhances glutamatergic neurotransmission without directly activating the receptor, offering a more controlled mechanism for cognitive enhancement and antidepressant effects. Originally developed for treatment-resistant depression, it has gained interest in the research community for its potential nootropic and neuroplasticity-promoting properties.

    Chemical Information

    IUPAC Name

    Not yet available

    CAS Number

    1531665-83-2

    Molecular Formula

    C16H11FN2O2

    Molecular Mass

    282.27 g/mol

    Dosing & Protocols

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    Research

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    • Safety and side effects
    • A link to the PubMed results

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    Interactions

    Interaction Matrix

    Contraindications

    History of seizure disorders or epilepsy. Concurrent use of other glutamatergic agents or excitatory compounds. Traumatic brain injury (acute phase). Pregnancy or breastfeeding. Known hypersensitivity to benzamide derivatives.

    Research Disclaimer

    This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.

    Best Price

    $79.99

    Best $/mg

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    Vendors

    1

    Listings

    1

    capsule

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    Vendor Product Form Qty Price $/mg Coupon
    BHG Labs logo
    BHG Labs
    70
    🇺🇸US
    TAK-653 capsule 1 bottle● In Stock $79.99BEST —

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    Current low
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    current listings
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    Tracking since Jul 1, 2026 · 1 data point

    Vendors Selling TAK-653

    How we score these vendors

    Every supplier above is graded 0 to 100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank.

    View Scorecard

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    TAK-653 (Osavampator / NBI-1065845): The Complete Research Reference

    TAK-653 (also called osavampator or NBI-1065845) is an investigational AMPA-receptor positive allosteric modulator designed to enhance glutamate signaling without the seizure liability of older ampakines. This reference covers its mechanism, the real Phase 1 and Phase 2 clinical evidence, how it differs from ketamine and older ampakines, community-reported use, honest safety framing, and where to source it. Research-use-only; not an approved drug.

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    4/21/2026

    Lowest Price

    BHG Labs logo

    BHG Labs

    $79.99

    1 vendor · 1 listing

    Research Score

    30

    0 PubMed results

    Quality Indicators

    Data Completeness

    88%
    Description
    Mechanism of Action
    Chemical Data
    Dosing Protocols
    Safety Profile
    PubMed Results
    Interactions
    Vendor Listings

    Quick Facts

    Half-Life

    6-10 hours (estimated)

    Molecular Weight

    282.27 g/mol

    Administration

    Oral

    CAS Number

    1531665-83-2

    Trial Phase

    Phase II Clinical Trials

    0

    Research Disclaimer

    This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.

    Frequently Asked Questions

    What is TAK-653 used for in research?

    TAK-653 is a novel positive allosteric modulator (PAM) of AMPA-type glutamate receptors developed by Takeda Pharmaceuticals. It enhances glutamatergic neurotransmission without directly activating the receptor, offering a more controlled mechanism for cognitive enhancement and antidepressant effects. Originally developed for treatment-resistant depression, it has gained interest in the research community for its potential nootropic and neuroplasticity-promoting properties.

    What forms does TAK-653 come in?

    TAK-653 is available in capsule form.

    How much does TAK-653 cost?

    Prices start at $79.99 across 1 vendor.

    How do I compare TAK-653 vendors?

    Compare prices, payment methods, shipping, and COA scores across 1 vendor.

    Research Tools

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    9-Me-BC (9-Methyl-β-carboline)

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    6 PubMedView Profile

    Aniracetam

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    t½ About half an hour for the parent drug in humans. Plasma elimination half-life was 0.47 to 0.49 hours after a single 400 mg oral dose in 20 healthy male volunteers (PMID: 19025058). Aniracetam is extensively metabolized to N-anisoyl-GABA and anisic acid; in six elderly hospitalized patients with cerebrovascular disease and reduced creatinine clearance, metabolite half-life was 4 to 7 times longer than in young volunteers (PMID: 9062694).
    PreclinicalView Profile

    Bemethyl (bemitil)

    NootropicsApproved (Russia)

    Bemethyl, known in the Russian literature as bemitil and sold in the region under names including Metaprot, Bemactor and Antihot, is 2-ethylthiobenzimidazole, normally handled as the hydrobromide salt.

    t½ Not established in humans; in healthy volunteers given a single 250 mg oral dose of the Metaprot capsule form, peak serum ethylthiobenzimidazole averaged 0.91 microg/mL at about 1.06 h, and no terminal half-life was reported (PMID: 21870773)
    PreclinicalView Profile

    Bromantane

    NootropicsRussia Approved

    Bromantane is an atypical psychostimulant and anxiolytic developed in the 1980s at the Zakusov Institute of Pharmacology of the Russian Academy of Medical Sciences, originally created as an adaptogen for Soviet military and elite athletic use and later approved in Russia for the treatment of neurasthenic and asthenic disorders under the trade name Ladasten.

    34 PubMedView Profile

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    Research Benches

    Reference pages that put TAK-653 next to the compounds people pair it with: roles, evidence, overlap and conflicts. No dosing. Research use only.

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