TAK-653
NootropicsPhase II Clinical TrialsTAK-653 is a novel positive allosteric modulator (PAM) of AMPA-type glutamate receptors developed by Takeda Pharmaceuticals. It enhances glutamatergic neurotransmission without directly activating the receptor, offering a more controlled mechanism for cognitive enhancement and antidepressant effects.
Overview
At A Glance
TAK-653 acts as a positive allosteric modulator (PAM) of AMPA receptors, binding to a site distinct from the glutamate binding site. It increases the receptor's sensitivity to glutamate, improving excitatory postsynaptic currents (EPSCs) and promoting long-term potentiation (LTP)…
Overview
TAK-653 is a novel positive allosteric modulator (PAM) of AMPA-type glutamate receptors developed by Takeda Pharmaceuticals. It enhances glutamatergic neurotransmission without directly activating the receptor, offering a more controlled mechanism for cognitive enhancement and antidepressant effects. Originally developed for treatment-resistant depression, it has gained interest in the research community for its potential nootropic and neuroplasticity-promoting properties.
Chemical Information
IUPAC Name
Not yet available
CAS Number
1531665-83-2
Molecular Formula
C16H11FN2O2
Molecular Mass
282.27 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
History of seizure disorders or epilepsy. Concurrent use of other glutamatergic agents or excitatory compounds. Traumatic brain injury (acute phase). Pregnancy or breastfeeding. Known hypersensitivity to benzamide derivatives.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
$79.99
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1
1
capsule
Tracking since Jul 1, 2026 · 1 data point
Vendors Selling TAK-653
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Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank.
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Protocols, calculator & safety for TAK-653
Related Articles
All PostsTAK-653 (Osavampator / NBI-1065845): The Complete Research Reference
TAK-653 (also called osavampator or NBI-1065845) is an investigational AMPA-receptor positive allosteric modulator designed to enhance glutamate signaling without the seizure liability of older ampakines. This reference covers its mechanism, the real Phase 1 and Phase 2 clinical evidence, how it differs from ketamine and older ampakines, community-reported use, honest safety framing, and where to source it. Research-use-only; not an approved drug.
7/1/2026BHG Labs review: a small, COA-backed nootropics and peptides vendor (2026)
BHG Labs is a small, US-focused research-chemical vendor selling atomized nasal sprays, single-compound nootropic capsules, and lyophilized peptides, all lot-numbered and third-party COA-linked. Everything is research-use-only. The catalog is curated rather than huge, and there's no large public review history yet, so it suits experienced self-experimenters more than first-timers. Code REDDIT takes 10% off.
6/30/2026Research Score
0 PubMed studies
Quality Indicators
Data Completeness
88%Quick Facts
Half-Life
6-10 hours (estimated)
Molecular Weight
282.27 g/mol
Administration
Oral
CAS Number
1531665-83-2
Trial Phase
Phase II Clinical Trials
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is TAK-653 used for in research?
TAK-653 is a novel positive allosteric modulator (PAM) of AMPA-type glutamate receptors developed by Takeda Pharmaceuticals. It enhances glutamatergic neurotransmission without directly activating the receptor, offering a more controlled mechanism for cognitive enhancement and antidepressant effects. Originally developed for treatment-resistant depression, it has gained interest in the research community for its potential nootropic and neuroplasticity-promoting properties.
What forms does TAK-653 come in?
TAK-653 is available in capsule form.
How much does TAK-653 cost?
Prices start at $79.99 across 1 verified vendor.
How do I compare TAK-653 vendors?
Compare prices, payment methods, shipping, and COA scores across 1 vendor.
Research Tools
Related Compounds
View All9-Me-BC (9-Methyl-β-carboline)
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Bromantane
NootropicsRussia ApprovedBromantane is an atypical psychostimulant and anxiolytic developed in the 1980s at the Zakusov Institute of Pharmacology of the Russian Academy of Medical Sciences, originally created as an adaptogen for Soviet military and elite athletic use and later approved in Russia for the treatment of neurasthenic and asthenic disorders under the trade name Ladasten.
Dihexa
NootropicsPreclinicalDihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University.
Kavain
NootropicsPreclinicalActive compound from kava for relaxation and sleep support..
KW-6356
NootropicsPhase 2b (program discontinued)KW-6356 is a selective adenosine A2A receptor antagonist/inverse agonist developed by Kyowa Kirin and studied for Parkinson's disease, both as monotherapy and as an add-on to levodopa.
L-Theanine
NootropicsFDA ApprovedL-Theanine is a non-proteinogenic amino acid found almost exclusively in tea (Camellia sinensis) and a handful of edible mushrooms, and it has become the single most widely-used calm-focus nootropic in the modern supplement market — both on its own at 100-400mg doses and, even more prominently, as the classic 1:1 or 2:1 pair with caffeine that defines the "calm-focus" experiential signature of green tea and of virtually every serious nootropic stack.
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