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    Phenylpiracetam molecular structure

    Phenylpiracetam

    NootropicsRussia Approved

    Phenylpiracetam is a Russian-developed phenyl derivative of piracetam with a dramatically higher potency and stimulant profile. Approved in Russia as Phenotropil/Carphedon for cognitive impairment and stroke recovery.

    CAS: 77472-70-91 PubMed Studies
    Last reviewed:
    1
    PubMed Studies
    Nootropics
    Category
    Russia Approved
    Research Stage

    Overview

    At A Glance

    Mechanism

    Phenylpiracetam's phenyl group addition dramatically increases lipophilicity and blood-brain barrier penetration compared to piracetam. It upregulates dopamine, norepinephrine, and serotonin receptor density — rather than triggering release — explaining the tolerance-free stimula

    Potential Benefits
    Cognitive stimulationPhysical performanceMemory enhancementCold toleranceMotivationAnti-convulsant
    Safety Notes
    Common
    Insomnia if dosed afternoon or laterIrritability at high dosesHeadache (without choline)Rapid tolerance (2–3 use window)

    Overview

    Phenylpiracetam is a Russian-developed phenyl derivative of piracetam with a dramatically higher potency and stimulant profile. Approved in Russia as Phenotropil/Carphedon for cognitive impairment and stroke recovery. Banned by WADA as a performance-improving drug due to its stimulant effects, significantly improving physical endurance in addition to cognition. One of the most potent and sought-after racetam family members.

    Potential Research Fields

    Cognitive impairmentStroke recoveryDepressionAthletic performanceEpilepsy

    Chemical Information

    IUPAC Name

    (RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide

    CAS Number

    77472-70-9

    Molecular Formula

    C12H14N2O2

    Molecular Mass

    218.25 g/mol

    Dosing & Protocols

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    Research

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    Interactions

    Interaction Matrix

    Contraindications

    Hypertension. History of seizures. Anxiety disorders. Pregnancy or breastfeeding.

    Research Disclaimer

    This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.

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    Related Compounds

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    9-Me-BC (9-Methyl-β-carboline)

    NootropicsPreclinical

    9-Methyl--carboline (9-Me-BC) is a synthetic -carboline alkaloid that has drawn nootropic-community interest for a preclinical property that is genuinely unusual among -carbolines: in rodent and cell-culture studies it appears to stimulate the dopaminergic phenotype - raising tyrosine hydroxylase, the number of differentiated dopamine neurons and dopamine content - while also showing neuroprotective, neurorestorative and anti-inflammatory effects, plus in-vitro MAO-A/MAO-B inhibition [PMID:17913302, PMID:20374418, PMID:32285253].

    t½ Not characterized in humans (no pharmacokinetic data). Community/anecdotal only: ~5-25 mg per day, oral. No validated or approved human dose exists.
    6 studiesView Profile

    Bromantane

    NootropicsRussia Approved

    Bromantane is an atypical psychostimulant and anxiolytic developed in the 1980s at the Zakusov Institute of Pharmacology of the Russian Academy of Medical Sciences, originally created as an adaptogen for Soviet military and elite athletic use and later approved in Russia for the treatment of neurasthenic and asthenic disorders under the trade name Ladasten.

    34 studiesView Profile

    Dihexa

    NootropicsPreclinical

    Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University.

    t½ Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence. 5 to 40 mg oral per day (anecdotal range; no established human dose)
    1 studiesView Profile

    Kavain

    NootropicsPreclinical for isolated kavain (in-vitro and animal mechanistic data). Human randomized controlled trials exist for the parent standardized kava extract, of which kavain is the principal kavalactone; the single molecule itself has not been trialed alone.

    Kavain (kawain) is the principal kavalactone in kava (Piper methysticum) and the main compound behind kava's calming, anxiolytic effect.

    t½ Not firmly established for isolated kavain in humans. Kavalactones are lipophilic and rapidly absorbed, with subjective effects generally lasting a few hours. Limited pharmacokinetic data preclude a precise elimination half-life. 50000-250000
    PreclinicalView Profile

    KW-6356

    NootropicsPhase 2b (program discontinued)

    KW-6356 is a selective adenosine A2A receptor antagonist/inverse agonist developed by Kyowa Kirin and studied for Parkinson's disease, both as monotherapy and as an add-on to levodopa.

    PreclinicalView Profile

    L-Theanine

    NootropicsFDA Approved

    L-Theanine is a non-proteinogenic amino acid found almost exclusively in tea (Camellia sinensis) and a handful of edible mushrooms, and it has become the single most widely-used calm-focus nootropic in the modern supplement market — both on its own at 100-400mg doses and, even more prominently, as the classic 1:1 or 2:1 pair with caffeine that defines the "calm-focus" experiential signature of green tea and of virtually every serious nootropic stack.

    t½ 1-3 hours (plasma); central CNS effect 3-5 hours
    1226 studiesView Profile

    View Full Dosage Guide →

    Protocols, calculator & safety for Phenylpiracetam

    Research Score

    60

    1 PubMed studies

    Quality Indicators

    Data Completeness

    75%
    Description
    Mechanism of Action
    Chemical Data
    Dosing Protocols
    Safety Profile
    PubMed Studies
    Interactions
    Vendor Listings

    Research Credibility

    1PubMed studies

    Limited research available

    Quick Facts

    Molecular Weight

    218.25 g/mol

    CAS Number

    77472-70-9

    Trial Phase

    Russia Approved

    Safety Profile

    Low Risk

    Common Side Effects

    • Insomnia if dosed afternoon or later
    • Irritability at high doses
    • Headache (without choline)
    • Rapid tolerance (2–3 use window)

    Stop Use If

    • Anxiety disorders — can exacerbate
    • Hypertension

    Research Disclaimer

    This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.

    Frequently Asked Questions

    What is Phenylpiracetam used for in research?

    Phenylpiracetam is a Russian-developed phenyl derivative of piracetam with a dramatically higher potency and stimulant profile. Approved in Russia as Phenotropil/Carphedon for cognitive impairment and stroke recovery. Banned by WADA as a performance-improving drug due to its stimulant effects, significantly improving physical endurance in addition to cognition. One of the most potent and sought-after racetam family members.

    What forms does Phenylpiracetam come in?

    Phenylpiracetam is available in vials, capsules, and sprays forms.

    How much does Phenylpiracetam cost?

    Pricing varies by vendor and form.

    How do I compare Phenylpiracetam vendors?

    Compare prices, payment methods, shipping, and COA scores across 0 vendors.

    Research Tools

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    9-Me-BC (9-Methyl-β-carboline)

    NootropicsPreclinical

    9-Methyl--carboline (9-Me-BC) is a synthetic -carboline alkaloid that has drawn nootropic-community interest for a preclinical property that is genuinely unusual among -carbolines: in rodent and cell-culture studies it appears to stimulate the dopaminergic phenotype - raising tyrosine hydroxylase, the number of differentiated dopamine neurons and dopamine content - while also showing neuroprotective, neurorestorative and anti-inflammatory effects, plus in-vitro MAO-A/MAO-B inhibition [PMID:17913302, PMID:20374418, PMID:32285253].

    t½ Not characterized in humans (no pharmacokinetic data). Community/anecdotal only: ~5-25 mg per day, oral. No validated or approved human dose exists.
    6 studiesView Profile

    Bromantane

    NootropicsRussia Approved

    Bromantane is an atypical psychostimulant and anxiolytic developed in the 1980s at the Zakusov Institute of Pharmacology of the Russian Academy of Medical Sciences, originally created as an adaptogen for Soviet military and elite athletic use and later approved in Russia for the treatment of neurasthenic and asthenic disorders under the trade name Ladasten.

    34 studiesView Profile

    Dihexa

    NootropicsPreclinical

    Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University.

    t½ Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence. 5 to 40 mg oral per day (anecdotal range; no established human dose)
    1 studiesView Profile

    Kavain

    NootropicsPreclinical for isolated kavain (in-vitro and animal mechanistic data). Human randomized controlled trials exist for the parent standardized kava extract, of which kavain is the principal kavalactone; the single molecule itself has not been trialed alone.

    Kavain (kawain) is the principal kavalactone in kava (Piper methysticum) and the main compound behind kava's calming, anxiolytic effect.

    t½ Not firmly established for isolated kavain in humans. Kavalactones are lipophilic and rapidly absorbed, with subjective effects generally lasting a few hours. Limited pharmacokinetic data preclude a precise elimination half-life. 50000-250000
    PreclinicalView Profile

    KW-6356

    NootropicsPhase 2b (program discontinued)

    KW-6356 is a selective adenosine A2A receptor antagonist/inverse agonist developed by Kyowa Kirin and studied for Parkinson's disease, both as monotherapy and as an add-on to levodopa.

    PreclinicalView Profile

    L-Theanine

    NootropicsFDA Approved

    L-Theanine is a non-proteinogenic amino acid found almost exclusively in tea (Camellia sinensis) and a handful of edible mushrooms, and it has become the single most widely-used calm-focus nootropic in the modern supplement market — both on its own at 100-400mg doses and, even more prominently, as the classic 1:1 or 2:1 pair with caffeine that defines the "calm-focus" experiential signature of green tea and of virtually every serious nootropic stack.

    t½ 1-3 hours (plasma); central CNS effect 3-5 hours
    1226 studiesView Profile

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