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Phenylpiracetam
NootropicsRussia ApprovedPhenylpiracetam is a Russian-developed phenyl derivative of piracetam with a dramatically higher potency and stimulant profile. Approved in Russia as Phenotropil/Carphedon for cognitive impairment and stroke recovery.
Overview
Key Takeaways
- →Cognitive stimulation
- →Physical performance
- →Memory enhancement
At A Glance
Phenylpiracetam's phenyl group addition dramatically increases lipophilicity and blood-brain barrier penetration compared to piracetam. It upregulates dopamine, norepinephrine, and serotonin receptor density — rather than triggering release — explaining the tolerance-free stimulant profile with cycling. It potentiates NMDA and AMPA receptor activity for enhanced glutamatergic learning and memory consolidation. Nicotinic acetylcholine receptor binding also contributes to its cognitive effects. In rodent models, it significantly increases locomotor activity, cold tolerance, and physical performance.
Phenylpiracetam's phenyl group addition dramatically increases lipophilicity and blood-brain barrier penetration compared to piracetam. It upregulates dopamine, norepinephrine, and serotonin receptor density — rather than triggering release — explaining the tolerance-free stimulant profile with cycling. It potentiates NMDA and AMPA receptor activity for enhanced glutamatergic learning and memory consolidation. Nicotinic acetylcholine receptor binding also contributes to its cognitive effects. In rodent models, it significantly increases locomotor activity, cold tolerance, and physical performance.
Overview
Phenylpiracetam is a Russian-developed phenyl derivative of piracetam with a dramatically higher potency and stimulant profile. Approved in Russia as Phenotropil/Carphedon for cognitive impairment and stroke recovery. Banned by WADA as a performance-enhancing drug due to its stimulant effects, significantly improving physical endurance in addition to cognition. One of the most potent and sought-after racetam family members.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
(RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide
CAS Number
77472-70-9
Molecular Formula
C12H14N2O2
Molecular Mass
218.25 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
Hypertension. History of seizures. Anxiety disorders. Pregnancy or breastfeeding.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
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Related Compounds
View All9-MBC (9-Methyl-β-carboline)
Nootropics
9-Methyl-β-carboline (9-MBC) is a synthetic β-carboline alkaloid that has gained significant interest in the nootropic community for its reported ability to promote dopaminergic neuron growth, increase dopamine synthesis enzymes, and provide neuroprotective effects against neurotoxins.
Alpha-GPC
Nootropics
Alpha-GPC (L-alpha glycerylphosphorylcholine) is a choline-containing phospholipid naturally present in the brain and found in small amounts in dairy and meat.
Bromantane
Nootropics
Bromantane (Ladasten) is an atypical psychostimulant and anxiolytic developed in Russia, approved there for asthenia.
CDP-Choline (Citicoline)
Nootropics
CDP-Choline (cytidine diphosphocholine, citicoline) is a naturally occurring nucleotide found in every cell in the body, and one of the most evidence-backed nootropics available.
Dihexa
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Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University.
Lion's Mane Mushroom
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Lion's Mane (Hericium erinaceus) is a medicinal mushroom with a growing body of clinical evidence for cognitive enhancement, neurogenesis, and nerve repair.
View Full Dosage Guide →
Protocols, calculator & safety for Phenylpiracetam
Research Score
1 PubMed studies
Quality Indicators
Data Completeness
75%Research Credibility
Limited research available
Quick Facts
Molecular Weight
218.25 g/mol
CAS Number
77472-70-9
Trial Phase
Russia Approved
Safety Profile
Low RiskCommon Side Effects
- • Insomnia if dosed afternoon or later
- • Irritability at high doses
- • Headache (without choline)
- • Rapid tolerance (2–3 use window)
Stop Use If
- Anxiety disorders — can exacerbate
- Hypertension
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is Phenylpiracetam used for in research?
Phenylpiracetam is a Russian-developed phenyl derivative of piracetam with a dramatically higher potency and stimulant profile. Approved in Russia as Phenotropil/Carphedon for cognitive impairment and stroke recovery. Banned by WADA as a performance-enhancing drug due to its stimulant effects, significantly improving physical endurance in addition to cognition. One of the most potent and sought-after racetam family members.
What forms does Phenylpiracetam come in?
Phenylpiracetam is available in vials, capsules, and sprays forms.
How much does Phenylpiracetam cost?
Pricing varies by vendor and form.
How do I compare Phenylpiracetam vendors?
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Research Tools
Related Compounds
View All9-MBC (9-Methyl-β-carboline)
Nootropics
9-Methyl-β-carboline (9-MBC) is a synthetic β-carboline alkaloid that has gained significant interest in the nootropic community for its reported ability to promote dopaminergic neuron growth, increase dopamine synthesis enzymes, and provide neuroprotective effects against neurotoxins.
Alpha-GPC
Nootropics
Alpha-GPC (L-alpha glycerylphosphorylcholine) is a choline-containing phospholipid naturally present in the brain and found in small amounts in dairy and meat.
Bromantane
Nootropics
Bromantane (Ladasten) is an atypical psychostimulant and anxiolytic developed in Russia, approved there for asthenia.
CDP-Choline (Citicoline)
Nootropics
CDP-Choline (cytidine diphosphocholine, citicoline) is a naturally occurring nucleotide found in every cell in the body, and one of the most evidence-backed nootropics available.
Dihexa
Nootropics
Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University.
Lion's Mane Mushroom
Nootropics
Lion's Mane (Hericium erinaceus) is a medicinal mushroom with a growing body of clinical evidence for cognitive enhancement, neurogenesis, and nerve repair.