PDRN
- Status
- Phase 4, , not approved for human use
- Evidence
-
Not graded on a research bench yet
PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation.
Reviewed
01Overview
What PDRN is
It consists of polynucleotide chains with molecular weights ranging from 50 to 1500 kDa. PDRN is widely used in Asian aesthetic medicine (particularly South Korea) for skin rejuvenation, wound healing, and hair loss treatment. It is available as an injectable sterile solution (Placentex Integro) licensed in several countries, as well as topical formulations and cosmetic creams. PDRN's mechanism centers on adenosine A2A receptor activation, stimulating collagen synthesis, cellular proliferation, and anti-inflammatory pathways. It is one of the few compounds in this catalog with a substantial published clinical (Phase 4) evidence base in aesthetic applications.
How it works
PDRN exerts effects through two primary mechanisms: (1) Adenosine A2A receptor agonism — PDRN is hydrolyzed to deoxyadenosine fragments that activate A2A receptors on fibroblasts, endothelial cells, and macrophages. A2A activation stimulates VEGF production (angiogenesis), collagen type I and III synthesis, and anti-inflammatory cytokine profiles (increased IL-10, decreased TNF-α). (2) Salvage pathway activation — DNA-derived nucleotides from PDRN are incorporated into the tissue nucleotide salvage pathway, providing precursors for DNA repair and cellular proliferation in wound healing. Together, these mechanisms accelerate fibroblast proliferation, neocollagenesis, angiogenesis, and tissue regeneration.
Benefits listed
- Wound healing acceleration - enhanced angiogenesis, fibroblast proliferation, and collagen synthesis
- Diabetic foot ulcer healing - supported by a randomized, double-blind, placebo-controlled trial (complete healing 37.3% vs 18.9% for placebo) [PMID:24483158]
- Skin rejuvenation - clinical studies suggest improved texture and elasticity, though a 2024 systematic review found the aesthetic evidence base inconsistent [PMID:39198280]
- Hair loss - preliminary evidence only; a small uncontrolled study in female pattern hair loss reported improved hair count and thickness (not established for androgenetic alopecia) [PMID:25524027]
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- Anti-inflammatory tissue remodeling - reduction of pro-inflammatory cytokines via adenosine A2A receptor signaling
- Aesthetic skin treatments - widely used in South Korean and European clinical practice
02Research
Free with emailWhat the research shows
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- A summary of the key research
- A link to the PubMed results
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03Safety
PDRN side effects and interactions
Side effects
Common
- Mild injection site bruising and swelling
- Transient redness
- Well tolerated in aesthetic clinical literature
Serious events
- Allergic reaction risk (salmon-derived product)
- No serious systemic adverse events in published aesthetic medicine RCTs
Interactions
Not in our record
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
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04Dosing
Free with emailPDRN dosage and protocols
- Dosing
- Weekly
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- Route and how often
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05Prices
PDRN prices
1 listing from 1 vendor, opening in the Featured order.
- Pack prices
- $34.95
- Lowest per mg
- Not listed
- Vendors
- 1
- Listings
- 1 (topical)
Prices as the vendors list them, last recorded 22 April 2026.
| Vendor | Product | Price | Buy |
|---|---|---|---|
|
PDRN Pink Cream topical, 1 jar In stock |
$34.95 No mg count |
Buy PDRN Pink Cream at Ion Peptide |
Vendors selling PDRN(1: trust score, certificates, payment, shipping)
-
Ion Peptide1 listing, from $34.95
Trust Score 70/100, no certificate records on file, pays by card, crypto, ACH, ships to the US, international destinations
Every supplier above is graded 0 to 100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. How we score these vendors
06Chemistry
Chemistry and structure
- Molecular mass
- No single value - PDRN is a heterogeneous mixture of deoxyribonucleotide polymers (chain lengths ~50-2000 bp, roughly 50-1500 kDa) rather than one defined molecule [PMID:19860658].
- Half-life
- Short (oligonucleotides degraded rapidly; tissue effects persist longer)
08Questions
Frequently asked questions
What is PDRN used for in research?
PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation. It consists of polynucleotide chains with molecular weights ranging from 50 to 1500 kDa. PDRN is widely used in Asian aesthetic medicine (particularly South Korea) for skin rejuvenation, wound healing, and hair loss treatment. It is available as an injectable sterile solution (Placentex Integro) licensed in several countries, as well as topical formulations and cosmetic creams. PDRN's mechanism centers on adenosine A2A receptor activation, stimulating collagen synthesis, cellular proliferation, and anti-inflammatory pathways. It is one of the few compounds in this catalog with a substantial published clinical (Phase 4) evidence base in aesthetic applications.
What forms does PDRN come in?
PDRN is available in topical form.
How do I compare PDRN vendors?
Compare prices, payment methods, shipping, and COA scores across 1 vendor.
How many vendors sell PDRN, and what does it cost per mg?
1 of the vendors BodyHackGuide tracks list PDRN (1 listing). The lowest listed price BodyHackGuide has recorded for PDRN is $34.95. No PDRN listing recorded as in stock carries a milligram count, so BodyHackGuide states no price per milligram for PDRN.
Which vendors have third-party COAs for PDRN on file at BodyHackGuide?
BodyHackGuide holds no third-party certificate records for PDRN. Each vendor page on BodyHackGuide shows how many certificate records BodyHackGuide holds for that vendor.
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