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NSI-189
NootropicsPhase 2NSI-189 is a novel synthetic compound developed by Neuralstem Inc. that stimulates neurogenesis in the human hippocampus.
Overview
Key Takeaways
- →Increased hippocampal neurogenesis
- →Antidepressant effects
- →Enhanced synaptic plasticity
At A Glance
NSI-189 stimulates proliferation and differentiation of human hippocampal neural stem cells through a mechanism distinct from BDNF or classical antidepressants. Rodent studies show a 20% increase in hippocampal volume after 6 weeks of treatment. It is not a receptor agonist or reuptake inhibitor — its precise molecular target remains uncharacterized, which is unusual for a Phase 2 compound. It appears to enhance synaptic plasticity in the dentate gyrus specifically, an area critical for pattern separation and emotional memory processing.
NSI-189 stimulates proliferation and differentiation of human hippocampal neural stem cells through a mechanism distinct from BDNF or classical antidepressants. Rodent studies show a 20% increase in hippocampal volume after 6 weeks of treatment. It is not a receptor agonist or reuptake inhibitor — its precise molecular target remains uncharacterized, which is unusual for a Phase 2 compound. It appears to enhance synaptic plasticity in the dentate gyrus specifically, an area critical for pattern separation and emotional memory processing.
Overview
NSI-189 is a novel synthetic compound developed by Neuralstem Inc. that stimulates neurogenesis in the human hippocampus. Phase 2 trials for major depressive disorder showed improvements in subjective cognitive function, depression scores, and positive affect despite not reaching primary endpoints. It has a dedicated following in the biohacking community for its reported hippocampal neurogenesis, emotional blunting reversal, and unique cognitive profile unlike any other nootropic.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
benzyl N-[2-(piperazin-1-yl)pyrimidin-5-yl]carbamate
CAS Number
1270138-40-3
Molecular Formula
C16H19N5O2
Molecular Mass
313.36 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
Pregnancy or breastfeeding. Active mania or bipolar disorder (limited data). Concurrent SSRI use requires medical supervision.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
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Related Compounds
View All9-MBC (9-Methyl-β-carboline)
Nootropics
9-Methyl-β-carboline (9-MBC) is a synthetic β-carboline alkaloid that has gained significant interest in the nootropic community for its reported ability to promote dopaminergic neuron growth, increase dopamine synthesis enzymes, and provide neuroprotective effects against neurotoxins.
Alpha-GPC
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Alpha-GPC (L-alpha glycerylphosphorylcholine) is a choline-containing phospholipid naturally present in the brain and found in small amounts in dairy and meat.
Bromantane
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CDP-Choline (Citicoline)
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CDP-Choline (cytidine diphosphocholine, citicoline) is a naturally occurring nucleotide found in every cell in the body, and one of the most evidence-backed nootropics available.
Dihexa
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Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University.
Lion's Mane Mushroom
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Lion's Mane (Hericium erinaceus) is a medicinal mushroom with a growing body of clinical evidence for cognitive enhancement, neurogenesis, and nerve repair.
View Full Dosage Guide →
Protocols, calculator & safety for NSI-189
Research Score
3 PubMed studies
Quality Indicators
Data Completeness
75%Research Credibility
Limited research available
Quick Facts
Molecular Weight
313.36 g/mol
CAS Number
1270138-40-3
Trial Phase
Phase 2
Safety Profile
Low RiskCommon Side Effects
- • Transient cognitive changes during initial use (cognitive shifting)
- • Anxiety in first weeks
- • Sleep changes
- • Emotional blunting (initial phase)
Stop Use If
- Active psychosis — hippocampal neurogenesis changes may worsen
- Bipolar disorder (monitor closely)
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is NSI-189 used for in research?
NSI-189 is a novel synthetic compound developed by Neuralstem Inc. that stimulates neurogenesis in the human hippocampus. Phase 2 trials for major depressive disorder showed improvements in subjective cognitive function, depression scores, and positive affect despite not reaching primary endpoints. It has a dedicated following in the biohacking community for its reported hippocampal neurogenesis, emotional blunting reversal, and unique cognitive profile unlike any other nootropic.
What forms does NSI-189 come in?
NSI-189 is available in vials, capsules, and sprays forms.
How much does NSI-189 cost?
Pricing varies by vendor and form.
How do I compare NSI-189 vendors?
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Research Tools
Related Compounds
View All9-MBC (9-Methyl-β-carboline)
Nootropics
9-Methyl-β-carboline (9-MBC) is a synthetic β-carboline alkaloid that has gained significant interest in the nootropic community for its reported ability to promote dopaminergic neuron growth, increase dopamine synthesis enzymes, and provide neuroprotective effects against neurotoxins.
Alpha-GPC
Nootropics
Alpha-GPC (L-alpha glycerylphosphorylcholine) is a choline-containing phospholipid naturally present in the brain and found in small amounts in dairy and meat.
Bromantane
Nootropics
Bromantane (Ladasten) is an atypical psychostimulant and anxiolytic developed in Russia, approved there for asthenia.
CDP-Choline (Citicoline)
Nootropics
CDP-Choline (cytidine diphosphocholine, citicoline) is a naturally occurring nucleotide found in every cell in the body, and one of the most evidence-backed nootropics available.
Dihexa
Nootropics
Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University.
Lion's Mane Mushroom
Nootropics
Lion's Mane (Hericium erinaceus) is a medicinal mushroom with a growing body of clinical evidence for cognitive enhancement, neurogenesis, and nerve repair.