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Gonadorelin
Hormones & Endocrine (Non-GH)FDA ApprovedGonadorelin is a synthetic form of endogenous gonadotropin-releasing hormone (GnRH). FDA-approved for fertility evaluation (GnRH stimulation test) and pulsatile pump therapy for hypothalamic amenorrhea.
Overview
Key Takeaways
- →HPG axis maintenance
- →LH/FSH stimulation
- →Testicular function during TRT
At A Glance
Gonadorelin acts on GnRH receptors on pituitary gonadotrophs, stimulating the synthesis and release of LH and FSH in a pulse-dependent manner. Pulsatile administration maintains the GnRH receptor pool through physiological desensitization cycles, preserving HPG axis responsiveness. Continuous administration causes receptor downregulation and paradoxical gonadotropin suppression — this is why pulsatile timing is critical for testosterone-supportive applications.
Gonadorelin acts on GnRH receptors on pituitary gonadotrophs, stimulating the synthesis and release of LH and FSH in a pulse-dependent manner. Pulsatile administration maintains the GnRH receptor pool through physiological desensitization cycles, preserving HPG axis responsiveness. Continuous administration causes receptor downregulation and paradoxical gonadotropin suppression — this is why pulsatile timing is critical for testosterone-supportive applications.
Overview
Gonadorelin is a synthetic form of endogenous gonadotropin-releasing hormone (GnRH). FDA-approved for fertility evaluation (GnRH stimulation test) and pulsatile pump therapy for hypothalamic amenorrhea. In the research and sports medicine community, it is used during and after anabolic steroid cycles to maintain testicular function and natural testosterone production.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
Pyroglutamyl-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
CAS Number
33515-09-2
Molecular Formula
C55H75N17O13
Molecular Mass
1182.32 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
Pregnancy or breastfeeding. Hormone-sensitive cancers. Children (unless under endocrinologist supervision). Known hypersensitivity to GnRH analogs.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
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Related Compounds
View AllKisspeptin-10
Hormones & Endocrine (Non-GH)
Kisspeptin-10 is the biologically active 10-amino acid C-terminal fragment of kisspeptin, the endogenous neuropeptide responsible for triggering puberty onset and regulating pulsatile GnRH secretion.
Oxytocin
Hormones & Endocrine (Non-GH)
Oxytocin is a naturally occurring nonapeptide hormone produced in the paraventricular nucleus of the hypothalamus and released from the posterior pituitary.
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Protocols, calculator & safety for Gonadorelin
Research Score
473 PubMed studies
Quality Indicators
Data Completeness
75%Research Credibility
Well-researched compound
Quick Facts
Molecular Weight
1182.32 g/mol
CAS Number
33515-09-2
Trial Phase
FDA Approved
Safety Profile
Low RiskCommon Side Effects
- • Injection site reactions
- • Mild nausea
- • Headache
- • Flushing
Stop Use If
- Hormone-sensitive cancers
- Hypersensitivity
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is Gonadorelin used for in research?
Gonadorelin is a synthetic form of endogenous gonadotropin-releasing hormone (GnRH). FDA-approved for fertility evaluation (GnRH stimulation test) and pulsatile pump therapy for hypothalamic amenorrhea. In the research and sports medicine community, it is used during and after anabolic steroid cycles to maintain testicular function and natural testosterone production.
What forms does Gonadorelin come in?
Gonadorelin is available in vials, capsules, and sprays forms.
How much does Gonadorelin cost?
Pricing varies by vendor and form.
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Research Tools
Related Compounds
View AllKisspeptin-10
Hormones & Endocrine (Non-GH)
Kisspeptin-10 is the biologically active 10-amino acid C-terminal fragment of kisspeptin, the endogenous neuropeptide responsible for triggering puberty onset and regulating pulsatile GnRH secretion.
Oxytocin
Hormones & Endocrine (Non-GH)
Oxytocin is a naturally occurring nonapeptide hormone produced in the paraventricular nucleus of the hypothalamus and released from the posterior pituitary.