Cortagen
LongevityPreclinicalAlso known as: Ala-Glu-Asp-Gly, Cardiac Bioregulator, Cortexin (related), Khavinson Cardiac Peptide
Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) from the Khavinson bioregulator family developed at the St. Petersburg Institute of Bioregulation and Gerontology.
Overview
At A Glance
Per the Khavinson mechanism, Cortagen binds to short complementary DNA sequences in the promoter regions of cardiac-specific genes, modulating gene expression in cardiomyocytes and coronary endothelial cells. Proposed downstream effects include upregulation of mitochondrial funct…
Overview
Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) from the Khavinson bioregulator family developed at the St. Petersburg Institute of Bioregulation and Gerontology. It is organ-targeted to cardiac and coronary tissue, studied for cardiac function preservation and coronary artery health in aging and post-ischemic models. Like other Khavinson bioregulators (Pinealon, Bronchogen, Cartalax, Epithalon), Cortagen is proposed to act via direct gene-regulatory mechanisms in target tissue rather than classical receptor-ligand signaling. Russian clinical literature includes use in elderly patients with cardiovascular disease and post-myocardial infarction recovery. It is distinct from the cortex-targeting Khavinson peptide Cortexin.
Chemical Information
IUPAC Name
Not yet available
CAS Number
Not yet available
Molecular Formula
Not yet available
Molecular Mass
Not yet available
Chemical data is being compiled for this compound.
Dosing & Protocols
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Research
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Interactions
Interaction and contraindication data is being compiled for Cortagen. Check back soon.
General Safety Note
Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented.
$79.00
$3.9500
1
1
vial
Tracking since Apr 22, 2026 · 1 data point
Vendors Selling Cortagen
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Related Compounds
View AllNAD+
LongevityPhase IINAD+ (nicotinamide adenine dinucleotide, oxidized form) is a pyridine dinucleotide coenzyme essential to energy metabolism, DNA repair via PARP enzymes, sirtuin-mediated gene regulation, and calcium signaling via CD38.
NMN
LongevityPreclinicalNicotinamide mononucleotide (NMN) is a naturally occurring nucleotide derived from ribose and nicotinamide, serving as the direct biosynthetic precursor to nicotinamide adenine dinucleotide (NAD+) via a single enzymatic step catalyzed by nicotinamide mononucleotide adenylyltransferase (NMNAT).
Rapamycin
LongevityPreclinicalRapamycin is a macrocyclic lactone antibiotic discovered in 1972 in soil samples from Rapa Nui (Easter Island) by a bacteriology survey team investigating indigenous Streptomyces species.
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Protocols, calculator & safety for Cortagen
Related Articles
All PostsResearch Score
0 PubMed studies
Quality Indicators
Data Completeness
63%Quick Facts
Half-Life
Unknown (tetrapeptide; estimated <4 hours)
Administration
Subcutaneous, Intramuscular
Trial Phase
Preclinical
Safety Profile
Common Side Effects
- • Injection site mild irritation
- • Low adverse event rate in published Russian case series
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is Cortagen used for in research?
Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) from the Khavinson bioregulator family developed at the St. Petersburg Institute of Bioregulation and Gerontology. It is organ-targeted to cardiac and coronary tissue, studied for cardiac function preservation and coronary artery health in aging and post-ischemic models. Like other Khavinson bioregulators (Pinealon, Bronchogen, Cartalax, Epithalon), Cortagen is proposed to act via direct gene-regulatory mechanisms in target tissue rather than classical receptor-ligand signaling. Russian clinical literature includes use in elderly patients with cardiovascular disease and post-myocardial infarction recovery. It is distinct from the cortex-targeting Khavinson peptide Cortexin.
What forms does Cortagen come in?
Cortagen is available in vial form.
How much does Cortagen cost?
Prices start at $79.00 across 1 verified vendor.
How do I compare Cortagen vendors?
Compare prices, payment methods, shipping, and COA scores across 1 vendor.
Research Tools
Related Compounds
View AllNAD+
LongevityPhase IINAD+ (nicotinamide adenine dinucleotide, oxidized form) is a pyridine dinucleotide coenzyme essential to energy metabolism, DNA repair via PARP enzymes, sirtuin-mediated gene regulation, and calcium signaling via CD38.
NMN
LongevityPreclinicalNicotinamide mononucleotide (NMN) is a naturally occurring nucleotide derived from ribose and nicotinamide, serving as the direct biosynthetic precursor to nicotinamide adenine dinucleotide (NAD+) via a single enzymatic step catalyzed by nicotinamide mononucleotide adenylyltransferase (NMNAT).
Rapamycin
LongevityPreclinicalRapamycin is a macrocyclic lactone antibiotic discovered in 1972 in soil samples from Rapa Nui (Easter Island) by a bacteriology survey team investigating indigenous Streptomyces species.
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