Cortagen
LongevityPreclinicalAlso known as: Ala-Glu-Asp-Gly, Cardiac Bioregulator, Cortexin (related), Khavinson Cardiac Peptide
Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) from the Khavinson bioregulator family developed at the St. Petersburg Institute of Bioregulation and Gerontology.
Overview
At A Glance
Cortagen is a synthetic tetrapeptide, Ala-Glu-Asp-Pro (AEDP), created by the Khavinson group through directed synthesis based on the amino-acid composition of Cortexin, a polypeptide complex extracted from the cerebral cortex [PMID:15159690]. It is a brain-cortex bioregulator, NO…
Overview
Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) from the Khavinson bioregulator family developed at the St. Petersburg Institute of Bioregulation and Gerontology. It is organ-targeted to cardiac and coronary tissue, studied for cardiac function preservation and coronary artery health in aging and post-ischemic models. Like other Khavinson bioregulators (Pinealon, Bronchogen, Cartalax, Epithalon), Cortagen is proposed to act via direct gene-regulatory mechanisms in target tissue rather than classical receptor-ligand signaling. Russian clinical literature includes use in elderly patients with cardiovascular disease and post-myocardial infarction recovery. It is distinct from the cortex-targeting Khavinson peptide Cortexin.
Chemical Information
IUPAC Name
Not yet available
CAS Number
Not yet available
Molecular Formula
Not yet available
Molecular Mass
430.4 g/mol
Amino Acid Sequence
Dosing & Protocols
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Research
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Interactions
Interaction and contraindication data is being compiled for Cortagen. Check back soon.
General Safety Note
Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented.
$79.00
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Tracking since Apr 22, 2026 · 1 data point
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Related Compounds
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NMN
LongevityPreclinicalNicotinamide mononucleotide (NMN) is a naturally occurring nucleotide derived from ribose and nicotinamide, serving as the direct biosynthetic precursor to nicotinamide adenine dinucleotide (NAD+) via a single enzymatic step catalyzed by nicotinamide mononucleotide adenylyltransferase (NMNAT).
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Protocols, calculator & safety for Cortagen
Related Articles
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Quality Indicators
Data Completeness
63%Quick Facts
Half-Life
Unknown (tetrapeptide; estimated <4 hours)
Molecular Weight
430.4 g/mol
Administration
Subcutaneous, Intramuscular
Trial Phase
Preclinical
Safety Profile
Common Side Effects
- • Injection-site irritation possible
- • Generally low adverse-event rate reported in the limited (mostly Russian) preclinical and clinical use
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is Cortagen?
Cortagen is a synthetic short-peptide bioregulator with the sequence Ala-Glu-Asp-Pro (AEDP). It was designed by Vladimir Khavinson and colleagues to reproduce the activity of Cortexin, a polypeptide preparation extracted from the cerebral cortex. It is studied mainly for nerve repair, neuroprotection, and anti-aging (chromatin) effects.
Is Cortagen a heart or cardiac peptide?
No. Cortagen is derived from brain-cortex peptides and acts mainly on nervous tissue. The Khavinson bioregulator aimed at cardiac tissue is a different peptide, Cardiogen (Ala-Glu-Asp-Arg). One exploratory mouse-microarray study reported that Cortagen changes some cardiac gene expression, but that is a screening result, not evidence of a cardioprotective indication.
What does the research actually show?
Peer-reviewed evidence is almost entirely Russian and preclinical: faster sciatic-nerve regeneration in rats, antioxidant and neuroprotective effects in the cerebral cortex and brain-ischemia models, mild immune-signaling modulation, and chromatin decondensation in lymphocytes from elderly donors. There are no rigorous Western placebo-controlled clinical trials.
Is Cortagen FDA-approved?
No. Cortagen is not approved by the FDA for any indication and is sold for research use only. It has been used clinically in Russia but has not been validated in Western controlled trials.
How is Cortagen dosed?
There is no validated human dosing standard. The only peer-reviewed quantitative dose is preclinical (10 mcg/kg intramuscularly once daily for 10 days in rats). Russian bioregulator courses typically run about 10 days. Treat any specific human dose as anecdotal and research-use-only.
Research Tools
Related Compounds
View AllNAD+
LongevityPhase IINAD+ (nicotinamide adenine dinucleotide, oxidized form) is a pyridine dinucleotide coenzyme essential to energy metabolism, DNA repair via PARP enzymes, sirtuin-mediated gene regulation, and calcium signaling via CD38.
NMN
LongevityPreclinicalNicotinamide mononucleotide (NMN) is a naturally occurring nucleotide derived from ribose and nicotinamide, serving as the direct biosynthetic precursor to nicotinamide adenine dinucleotide (NAD+) via a single enzymatic step catalyzed by nicotinamide mononucleotide adenylyltransferase (NMNAT).
Rapamycin
LongevityPreclinicalRapamycin is a macrocyclic lactone antibiotic discovered in 1972 in soil samples from Rapa Nui (Easter Island) by a bacteriology survey team investigating indigenous Streptomyces species.
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