Vilon vs NAD+
Side-by-side comparison of Vilon and NAD+: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Vilon
NAD+
Vilon
Vilon is the simplest member of Vladimir Khavinson's short-peptide bioregulator catalog — a dipeptide of lysine and glutamic acid (H-Lys-Glu-OH, abbreviated KE). Developed at the Saint Petersburg Institute of…
No vendor price on file.
Full Vilon profileNAD+
NAD+ (nicotinamide adenine dinucleotide, oxidized form) is a pyridine dinucleotide coenzyme essential to energy metabolism, DNA repair via PARP enzymes, sirtuin-mediated gene regulation, and calcium signaling via CD38.…
Lowest listed price: $25.00 across 11 listings
Full NAD+ profileSide-by-side comparison
| Attribute | Vilon | NAD+ |
|---|---|---|
| Category | Recovery | Longevity |
| Research Stage | Preclinical | Phase II |
| Mechanism of Action | Vilon's proposed mechanism follows the Khavinson three-stage framework applied to the simplest-possible peptide. Stage one is absorption: oral Vilon is claimed to be absorbed intact from the gut because it is small enough (275 Da) to cross the intestinal… | Redox Cofactor Function NAD+ serves as the primary electron acceptor in catabolic reactions (glycolysis, TCA cycle, fatty acid oxidation), cycling between its oxidized (NAD+) and reduced (NADH) forms. This fundamental energy metabolism role means every cell… |
| Half-Life | Not established in humans; as a dipeptide (Lys-Glu) it is expected to be cleared from plasma within minutes, with proposed effects attributed to transient gene-expression modulation rather than sustained blood levels. | Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent |
| Typical Dose Range | 20 mg oral capsule (~2-4 mg Lys-Glu peptide), 1-2 capsules daily for 10 consecutive days per cycle | Oral precursors: NR 300-2,000 mg/day, NMN 250-900 mg/day, NAM 500-1,500 mg/day; IV NAD+ 500-1,500 mg per session. |
| Dosing Frequency | — | Oral precursors once daily (higher doses split AM/midday); IV NAD+ weekly-to-monthly at clinics. |
| Administration | — | Oral (precursors), Intravenous, Intramuscular, Subcutaneous |
| Side Effects | Published Khavinson-group observations describe Vilon as exceptionally well tolerated at oral doses of 1 to 2 capsules daily during 10-day cycles. The structural simplicity of the dipeptide — lysine and glutamate, both ubiquitous amino acids — and the low… | Nicotinamide Riboside (NR) NR has the best-characterized safety profile of the NAD+ precursors. Across published RCTs at 1,000-2,000 mg/day for up to 12 weeks, adverse effects have been mild and uncommon: - Gastrointestinal upset (5-10% of users) - Mild… |
| Molecular Weight | 275.3 Da (C11H21N3O5) | 663.4 g/mol (NAD+); NR 255.3 g/mol; NMN 334.2 g/mol; NAM 122.1 g/mol |
| Common Vial Sizes | — | 100mg, 250mg, 500mg |
Price History
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Vilon: potential benefits
- Immune system support
- Tissue repair enhancement
- Anti-aging immune modulation
- General health optimization
NAD+: potential benefits
- Restores age-associated NAD+ decline — 50% loss between young and older adulthood
- Increases peripheral blood NAD+ by up to 142% at 1,000 mg NR daily (Elhassan 2019)
- Supports sirtuin-mediated gene regulation and PARP-mediated DNA repair
- Improves muscle insulin sensitivity in prediabetic postmenopausal women (Yoshino 2021)
- Increases aerobic performance in amateur runners at 300-600 mg NMN (Liao 2021)
- Reduces inflammatory cytokines (IL-6, TNF-alpha) in middle-aged/elderly (Martens, Elhassan)
- Brain NAD+ elevation demonstrated in Parkinson trial (Brakedal 2022)
- Excellent safety profile at evidence-supported doses (500-2000 mg/day NR)
Frequently asked
What's the difference between Vilon and NAD+?
Vilon is a recovery that vilon's proposed mechanism follows the khavinson three-stage framework applied to the simplest-possible peptide. stage one is absorption: oral vilon is claimed to be absorbed…. NAD+ is a longevity that redox cofactor function nad+ serves as the primary electron acceptor in catabolic reactions (glycolysis, tca cycle, fatty acid oxidation), cycling between its oxidized (nad+) and…. The two differ in mechanism, half-life (Not established in humans; as a dipeptide (Lys-Glu) it is expected to be cleared from plasma within minutes, with proposed effects attributed to transient gene-expression modulation rather than sustained blood levels. vs Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent), and typical dose range.
Which has the longer half-life, Vilon or NAD+?
Vilon has a half-life of Not established in humans; as a dipeptide (Lys-Glu) it is expected to be cleared from plasma within minutes, with proposed effects attributed to transient gene-expression modulation rather than sustained blood levels.. NAD+ has a half-life of Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Can you stack Vilon and NAD+?
Stacking depends on mechanism overlap, safety profile, and goals. Vilon and NAD+ should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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