Uridine Monophosphate (UMP) vs Selank
Side-by-side comparison of Uridine Monophosphate (UMP) and Selank: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Uridine Monophosphate (UMP)
Selank
Uridine Monophosphate (UMP)
Uridine monophosphate (UMP, also written 5'-UMP or uridine-5'-monophosphate) is the nucleotide form of uridine, consisting of the pyrimidine base uracil linked to a ribose sugar phosphorylated at the 5' position. It is…
No vendor price on file.
Full Uridine Monophosphate (UMP) profileSelank
Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro, 750 Da molecular weight) developed in the 1990s at the Institute of Molecular Genetics of the Russian Academy of Sciences as a synthetic analog of tuftsin…
Lowest listed price: $25.00 across 6 listings
Full Selank profileSide-by-side comparison
| Attribute | Uridine Monophosphate (UMP) | Selank |
|---|---|---|
| Category | Nootropics | Nootropics |
| Research Stage | Clinical (human studies of uridine alone and inside the Souvenaid drink; the prodrug uridine triacetate is FDA-approved) | Approved (Russia, as anxiolytic and nootropic medication) |
| Mechanism of Action | Uridine monophosphate's mechanism of action as a nootropic is grounded in its role as a precursor for membrane phospholipid synthesis via the Kennedy pathway, with additional proposed effects on purinergic signalling, dopaminergic function, and synaptic… | Primary Mechanism: Multi-System Neurochemical Modulation Selank does not have a single clean receptor-binding mechanism. Unlike benzodiazepines (GABA-A positive allosteric modulators), SSRIs (serotonin reuptake inhibition), or buspirone (5-HT1A partial… |
| Half-Life | — | ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation) |
| Typical Dose Range | — | 250-750 mcg intranasal daily (0.15% solution: 2-3 drops per nostril 2-3x daily); typical course is 14-21 days |
| Dosing Frequency | — | Intranasal 1–3 times daily |
| Administration | — | Intranasal |
| Side Effects | Uridine monophosphate has one of the most favourable safety profiles of any supplement in the nootropic space. It is a naturally occurring nutrient, present in human breast milk, liver, fish, and many other foods. Clinical trials with daily doses up to 2 grams… | Overall Safety Profile Selank has one of the best safety profiles in the anxiolytic space. Over 15+ years of Russian clinical use and research, the compound has been associated with essentially no serious adverse events at therapeutic doses. This compares… |
| Molecular Weight | 324.18 g/mol | 751.9 Da |
| Common Vial Sizes | — | 5mg, 10mg |
Price History
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Uridine Monophosphate (UMP): potential benefits
- D2/D3 receptor upregulation
- Mood stabilization
- Memory improvement
- Synaptic plasticity
- Neuronal membrane support
- Long-term cognitive enhancement
Selank: potential benefits
- Anxiolytic effects comparable to benzodiazepines but without sedation or dependence in Russian clinical trials (PMID: 18454096)
- Positive allosteric modulation of brain GABA receptors through a non-benzodiazepine binding site (PMID: 30255741)
- Immunomodulation via Th1/Th2 cytokine balance and IL-6 regulation in patients with anxiety-asthenic disorders (PMID: 18577961)
- Cognitive and memory support linked to BDNF upregulation in the hippocampus in preclinical models (PMID: 18841804)
- Modulation of the endogenous enkephalin-opioid system supporting mood and stress tolerance (PMID: 22550852)
- Anti-inflammatory and adaptogenic effects through normalization of stress-induced cytokine dysregulation
- Non-addictive anxiolytic profile - no tolerance, withdrawal, or dependence reported across years of Russian clinical use
Frequently asked
What's the difference between Uridine Monophosphate (UMP) and Selank?
Uridine Monophosphate (UMP) is a nootropics that uridine monophosphate's mechanism of action as a nootropic is grounded in its role as a precursor for membrane phospholipid synthesis via the kennedy pathway, with additional…. Selank is a nootropics that primary mechanism: multi-system neurochemical modulation selank does not have a single clean receptor-binding mechanism. unlike benzodiazepines (gaba-a positive allosteric…. The two differ in mechanism, half-life (not reported vs ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation)), and typical dose range.
Which has the longer half-life, Uridine Monophosphate (UMP) or Selank?
Uridine Monophosphate (UMP) has a half-life of not reported. Selank has a half-life of ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation). Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Can you stack Uridine Monophosphate (UMP) and Selank?
Stacking depends on mechanism overlap, safety profile, and goals. Uridine Monophosphate (UMP) and Selank should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.