Uridine Monophosphate (UMP) vs Dihexa
Side-by-side comparison of Uridine Monophosphate (UMP) and Dihexa: mechanism, half-life, dose range, safety profile, and vendor pricing.
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Uridine Monophosphate (UMP)
Dihexa
Uridine Monophosphate (UMP)
Uridine monophosphate (UMP, also written 5'-UMP or uridine-5'-monophosphate) is the nucleotide form of uridine, consisting of the pyrimidine base uracil linked to a ribose sugar phosphorylated at the 5' position. It is…
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Full Uridine Monophosphate (UMP) profileDihexa
Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. It is considered one of the most potent cognitive enhancers ever tested in animal models…
Lowest listed price: $79.99 across 3 listings
Full Dihexa profileSide-by-side comparison
| Attribute | Uridine Monophosphate (UMP) | Dihexa |
|---|---|---|
| Category | Nootropics | Nootropics |
| Research Stage | Preclinical | Preclinical |
| Mechanism of Action | Uridine monophosphate's mechanism of action as a nootropic is grounded in its role as a precursor for membrane phospholipid synthesis via the Kennedy pathway, with additional proposed effects on purinergic signalling, dopaminergic function, and synaptic… | Dihexa is a small-molecule analog derived from angiotensin IV (AngIV). It retains the Tyr-Ile core of Nle1-AngIV, with an N-terminal hexanoic acid cap and a C-terminal 6-aminohexanoic amide that give it metabolic stability and blood-brain-barrier penetration.… |
| Half-Life | — | Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence. |
| Typical Dose Range | — | 5 to 40 mg oral per day (anecdotal range; no established human dose) |
| Dosing Frequency | — | Once daily (oral), typically in the morning |
| Administration | — | Oral, Intranasal, Subcutaneous |
| Side Effects | Uridine monophosphate has one of the most favourable safety profiles of any supplement in the nootropic space. It is a naturally occurring nutrient, present in human breast milk, liver, fish, and many other foods. Clinical trials with daily doses up to 2 grams… | No controlled human safety data. Anecdotal user reports include headache, fatigue, irritability or anxiety, insomnia, and vivid dreams, usually at higher doses. The most serious concern is theoretical rather than reported: because dihexa acts on the HGF/c-Met… |
| Molecular Weight | 324.18 g/mol | 504.7 g/mol |
| Common Vial Sizes | — | 50mg, 100mg |
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Uridine Monophosphate (UMP): potential benefits
- D2/D3 receptor upregulation
- Mood stabilization
- Memory improvement
- Synaptic plasticity
- Neuronal membrane support
- Long-term cognitive enhancement
Dihexa: potential benefits
- Synaptogenesis: formation of new dendritic spines and functional synapses (preclinical)
- Memory and spatial-learning support in rodent models
- Potential research application in Alzheimer's and other neurodegenerative disease models
- HGF/c-Met and PI3K/Akt-linked neuroplasticity (mechanism proposed; key paper retracted)
Frequently asked
What's the difference between Uridine Monophosphate (UMP) and Dihexa?
Uridine Monophosphate (UMP) is a nootropics that uridine monophosphate's mechanism of action as a nootropic is grounded in its role as a precursor for membrane phospholipid synthesis via the kennedy pathway, with additional…. Dihexa is a nootropics that dihexa is a small-molecule analog derived from angiotensin iv (angiv). it retains the tyr-ile core of nle1-angiv, with an n-terminal hexanoic acid cap and a c-terminal…. The two differ in mechanism, half-life (not reported vs Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence.), and typical dose range.
Which has the longer half-life, Uridine Monophosphate (UMP) or Dihexa?
Uridine Monophosphate (UMP) has a half-life of not reported. Dihexa has a half-life of Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Can you stack Uridine Monophosphate (UMP) and Dihexa?
Stacking depends on mechanism overlap, safety profile, and goals. Uridine Monophosphate (UMP) and Dihexa should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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