Tesofensine vs MOTS-c
Side-by-side comparison of Tesofensine and MOTS-c: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Tesofensine
MOTS-c
Tesofensine
Tesofensine (NS2330) is an orally-administered small-molecule triple monoamine reuptake inhibitor — it blocks the reuptake of noradrenaline, dopamine, and serotonin, placing it in the same broad pharmacologic class as…
Lowest listed price: $79.99 across 2 listings
Full Tesofensine profileMOTS-c
MOTS-c (Mitochondrial ORF of the Twelve S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide — a member of a recently discovered class of small peptides encoded in mitochondrial DNA rather than nuclear DNA. It…
Lowest listed price: $44.99 across 9 listings
Full MOTS-c profileSide-by-side comparison
| Attribute | Tesofensine | MOTS-c |
|---|---|---|
| Category | Weight Loss | Longevity & Cellular Health |
| Research Stage | Preclinical | Preclinical |
| Mechanism of Action | Tesofensine blocks the presynaptic reuptake of three monoamine neurotransmitters: noradrenaline (norepinephrine), dopamine, and serotonin. By inhibiting the neurotransmitter transporters (NET, DAT, and SERT respectively), tesofensine raises synaptic… | A New Class of Signaling Molecule MOTS-c belongs to the mitochondrial-derived peptides (MDPs) - a class of small peptides encoded within mitochondrial DNA open reading frames that were historically thought to encode only ribosomal RNAs. The known MDPs include:… |
| Half-Life | — | ~4–6 hours |
| Typical Dose Range | 0.25 mg - 1 mg daily (oral) | 5,000–10,000 mcg (5–10 mg) per injection |
| Dosing Frequency | — | 2-3 times per week |
| Administration | — | Subcutaneous, Intramuscular |
| Side Effects | Tesofensine's side effect profile reflects its monoamine-enhancing mechanism. Most effects are predictable extensions of NE, DA, and 5-HT elevation. The cardiovascular profile is the dominant clinical concern and the primary reason regulators have not approved… | Reported Effects (limited human data) - Injection site reactions — Mild erythema, transient itching at SC injection site. Site rotation minimizes. Probably the single most reported issue. - Transient fatigue — Some users report mild fatigue in the first week… |
| Molecular Weight | 298.24 g/mol | 2174 Da |
| Common Vial Sizes | — | 5mg, 10mg |
Price tracking
Price History
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Tesofensine: potential benefits
- Significant weight loss (10-15% body weight)
- Appetite suppression
- Increased metabolic rate
- Enhanced dopamine-driven motivation
MOTS-c: potential benefits
- Insulin sensitivity
- Exercise mimicry
- Metabolic health
- Anti-aging
- Fat oxidation
- Longevity
Frequently asked
What's the difference between Tesofensine and MOTS-c?
Tesofensine is a weight loss that tesofensine blocks the presynaptic reuptake of three monoamine neurotransmitters: noradrenaline (norepinephrine), dopamine, and serotonin. by inhibiting the neurotransmitter…. MOTS-c is a longevity & cellular health that a new class of signaling molecule mots-c belongs to the mitochondrial-derived peptides (mdps) - a class of small peptides encoded within mitochondrial dna open reading frames that…. The two differ in mechanism, half-life (not reported vs ~4–6 hours), and typical dose range.
Which has the longer half-life, Tesofensine or MOTS-c?
Tesofensine has a half-life of not reported. MOTS-c has a half-life of ~4–6 hours. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Tesofensine or MOTS-c?
Lowest listed price on BodyHackGuide: Tesofensine from $79.99, MOTS-c from $44.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack Tesofensine and MOTS-c?
Stacking depends on mechanism overlap, safety profile, and goals. Tesofensine and MOTS-c should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
See current vendor prices
Listings from the vendors we track. Prices change often, so check the vendor before you buy.
Before you buy Tesofensine or MOTS-c
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.