Phenibut vs Noopept
Side-by-side comparison of Phenibut and Noopept: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Phenibut
Noopept
Phenibut
Phenibut is the common Western name for β-phenyl-γ-aminobutyric acid (beta-phenyl-GABA; Russian trade names Phenibut/Фенибут, Noofen, Anvifen), a Soviet-era anxiolytic and nootropic developed in the 1960s at the Herzen…
Lowest listed price: $49.99 across 1 listing
Full Phenibut profileNoopept
Noopept is the common brand and research name for N-phenylacetyl-L-prolylglycine ethyl ester (GVS-111; INN omberacetam), a small dipeptide nootropic developed in the 1990s at the Russian Academy of Medical Sciences'…
Lowest listed price: $49.99 across 1 listing
Full Noopept profileSide-by-side comparison
| Attribute | Phenibut | Noopept |
|---|---|---|
| Category | Nootropics | Nootropics |
| Research Stage | Prescription Medicine (Russia/CIS) / Unregulated Elsewhere | Preclinical |
| Mechanism of Action | Phenibut's pharmacology is dominated by activity at the GABA-B receptor, with secondary effects at GABA-A receptors and voltage-gated calcium channels. Understanding these three components is essential to understanding both its therapeutic effects and its… | Noopept's mechanism of action is multifaceted and — despite decades of research — incompletely understood. Several convergent pathways have been proposed, each supported by preclinical data but none definitively established as the primary driver of its… |
| Half-Life | 5-8 hours (plasma); central CNS effect 10-16 hours | — |
| Typical Dose Range | — | — |
| Dosing Frequency | — | — |
| Administration | Oral | — |
| Side Effects | Phenibut's side effects fall into three categories: acute-dose effects (largely dose-dependent sedation and impairment), withdrawal effects (physiologically similar to benzodiazepine/alcohol withdrawal), and interactions with other CNS depressants (additive… | Noopept is generally well tolerated in the Russian clinical literature, with side effects that are typically mild and transient. However, "well tolerated in Russian open-label trials" is a weaker safety claim than the rigorous multi-phase trial data underlying… |
| Molecular Weight | 179.22 g/mol (free base); 215.68 g/mol (HCl salt) | 318.37 g/mol |
| Common Vial Sizes | — | — |
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Price History
2 data pointsPhenibut: potential benefits
- No structured benefit list published.
Noopept: potential benefits
- Memory enhancement
- BDNF/NGF upregulation
- Neuroprotection
- Focus and learning speed
- Anxiety reduction (moderate)
- Anti-amyloid properties
Frequently asked
What's the difference between Phenibut and Noopept?
Phenibut is a nootropics that phenibut's pharmacology is dominated by activity at the gaba-b receptor, with secondary effects at gaba-a receptors and voltage-gated calcium channels. understanding these three…. Noopept is a nootropics that noopept's mechanism of action is multifaceted and — despite decades of research — incompletely understood. several convergent pathways have been proposed, each supported by…. The two differ in mechanism, half-life (5-8 hours (plasma); central CNS effect 10-16 hours vs not reported), and typical dose range.
Which has the longer half-life, Phenibut or Noopept?
Phenibut has a half-life of 5-8 hours (plasma); central CNS effect 10-16 hours. Noopept has a half-life of not reported. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Phenibut or Noopept?
Lowest listed price on BodyHackGuide: Phenibut from $49.99, Noopept from $49.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack Phenibut and Noopept?
Stacking depends on mechanism overlap, safety profile, and goals. Phenibut and Noopept should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Listings from the vendors we track. Prices change often, so check the vendor before you buy.
Before you buy Phenibut or Noopept
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.