Phenibut vs Dihexa
Side-by-side comparison of Phenibut and Dihexa: mechanism, half-life, dose range, safety profile, and vendor pricing.
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Phenibut
Dihexa
Phenibut
Phenibut is the common Western name for β-phenyl-γ-aminobutyric acid (beta-phenyl-GABA; Russian trade names Phenibut/Фенибут, Noofen, Anvifen), a Soviet-era anxiolytic and nootropic developed in the 1960s at the Herzen…
Lowest listed price: $49.99 across 1 listing
Full Phenibut profileDihexa
Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. It is considered one of the most potent cognitive enhancers ever tested in animal models…
Lowest listed price: $79.99 across 3 listings
Full Dihexa profileSide-by-side comparison
| Attribute | Phenibut | Dihexa |
|---|---|---|
| Category | Nootropics | Nootropics |
| Research Stage | Prescription Medicine (Russia/CIS) / Unregulated Elsewhere | Preclinical |
| Mechanism of Action | Phenibut's pharmacology is dominated by activity at the GABA-B receptor, with secondary effects at GABA-A receptors and voltage-gated calcium channels. Understanding these three components is essential to understanding both its therapeutic effects and its… | Dihexa is a small-molecule analog derived from angiotensin IV (AngIV). It retains the Tyr-Ile core of Nle1-AngIV, with an N-terminal hexanoic acid cap and a C-terminal 6-aminohexanoic amide that give it metabolic stability and blood-brain-barrier penetration.… |
| Half-Life | 5-8 hours (plasma); central CNS effect 10-16 hours | Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence. |
| Typical Dose Range | — | 5 to 40 mg oral per day (anecdotal range; no established human dose) |
| Dosing Frequency | — | Once daily (oral), typically in the morning |
| Administration | Oral | Oral, Intranasal, Subcutaneous |
| Side Effects | Phenibut's side effects fall into three categories: acute-dose effects (largely dose-dependent sedation and impairment), withdrawal effects (physiologically similar to benzodiazepine/alcohol withdrawal), and interactions with other CNS depressants (additive… | No controlled human safety data. Anecdotal user reports include headache, fatigue, irritability or anxiety, insomnia, and vivid dreams, usually at higher doses. The most serious concern is theoretical rather than reported: because dihexa acts on the HGF/c-Met… |
| Molecular Weight | 179.22 g/mol (free base); 215.68 g/mol (HCl salt) | 504.7 g/mol |
| Common Vial Sizes | — | 50mg, 100mg |
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Phenibut: potential benefits
- No structured benefit list published.
Dihexa: potential benefits
- Synaptogenesis: formation of new dendritic spines and functional synapses (preclinical)
- Memory and spatial-learning support in rodent models
- Potential research application in Alzheimer's and other neurodegenerative disease models
- HGF/c-Met and PI3K/Akt-linked neuroplasticity (mechanism proposed; key paper retracted)
Frequently asked
What's the difference between Phenibut and Dihexa?
Phenibut is a nootropics that phenibut's pharmacology is dominated by activity at the gaba-b receptor, with secondary effects at gaba-a receptors and voltage-gated calcium channels. understanding these three…. Dihexa is a nootropics that dihexa is a small-molecule analog derived from angiotensin iv (angiv). it retains the tyr-ile core of nle1-angiv, with an n-terminal hexanoic acid cap and a c-terminal…. The two differ in mechanism, half-life (5-8 hours (plasma); central CNS effect 10-16 hours vs Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence.), and typical dose range.
Which has the longer half-life, Phenibut or Dihexa?
Phenibut has a half-life of 5-8 hours (plasma); central CNS effect 10-16 hours. Dihexa has a half-life of Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Phenibut or Dihexa?
Lowest listed price on BodyHackGuide: Phenibut from $49.99, Dihexa from $79.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack Phenibut and Dihexa?
Stacking depends on mechanism overlap, safety profile, and goals. Phenibut and Dihexa should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
See current vendor prices
Listings from the vendors we track. Prices change often, so check the vendor before you buy.
Before you buy Phenibut or Dihexa
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.