PEG-MGF vs Pinealon
Side-by-side comparison of PEG-MGF and Pinealon: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
PEG-MGF
Pinealon
PEG-MGF
PEG-MGF (Pegylated Mechano Growth Factor) is a synthetic, PEGylated form of Mechano Growth Factor (MGF) — an alternatively spliced variant of IGF-1 produced locally in muscle and other tissues in response to mechanical…
Lowest listed price: $39.00 across 1 listing
Full PEG-MGF profilePinealon
Pinealon is a synthetic tripeptide — glutamyl-aspartyl-arginine (Glu-Asp-Arg, or EDR) — developed by the St Petersburg Institute of Bioregulation and Gerontology (IBG) under the leadership of Professor Vladimir…
Lowest listed price: $45.00 across 3 listings
Full Pinealon profileSide-by-side comparison
| Attribute | PEG-MGF | Pinealon |
|---|---|---|
| Category | Performance | Nootropics |
| Research Stage | Preclinical | Preclinical |
| Mechanism of Action | PEG-MGF is the PEGylated form of Mechano Growth Factor (MGF), a synthetic peptide corresponding to the C-terminal 24 amino acids of the unique E-domain of IGF-1Ec, an alternatively spliced variant of the IGF-1 gene expressed in skeletal muscle after mechanical… | The proposed mechanism of Pinealon is rooted in the Khavinson school's broader theory of short-peptide tissue-specific bioregulation. The full theory is worth understanding because it underlies all twelve Russian bioregulator compounds in this catalog. The… |
| Half-Life | Native MGF: very short (minutes) due to rapid proteolysis. PEG-MGF: PEGylation is intended to extend this substantially (community estimates up to roughly 1 day), but there are no published human pharmacokinetic data to confirm a specific value. | Not formally characterized in humans. Short regulatory peptides of this class are cleared from plasma within minutes; the Khavinson framework proposes durable downstream gene-expression effects that outlast the brief dosing window, which is the stated rationale for pulsed cycling rather than continuous dosing. |
| Typical Dose Range | 200 mcg | Subcutaneous (primary route): 2-10 mg/day, typically 3-5 mg, in pulsed 10-20 day cycles, 2-4 cycles/year. Intranasal: 150-800 mcg per nostril daily. Research use only; oral dosing is not recommended because the peptide is largely degraded by GI proteases. |
| Dosing Frequency | twice_weekly | Once daily during a cycle (morning preferred); some advanced users split into AM + midday doses. Not dosed continuously year-round - cycles are pulsed. |
| Administration | Subcutaneous, Intramuscular, Intravenous | — |
| Side Effects | — | The side-effect profile of Pinealon, based on the available Russian clinical literature and user-reported experience, is described as mild and uncommon. Whether this reflects genuinely low toxicity or inadequate reporting in the available studies is a… |
| Molecular Weight | Free MGF 24-aa peptide: approximately 2,867-2,868 Da (reported molecular formula ~C121H199N41O40). PEG-MGF is heavier: the conjugated polyethylene glycol adds a variable mass (commonly a few kDa) on top of the peptide, so total mass depends on the PEG used. | 418.40 g/mol (C15H26N6O8) |
| Common Vial Sizes | 2 | — |
Price tracking
Price History
2 data points- Ion Peptide
- Disguised Alpha
PEG-MGF: potential benefits
- Increases satellite-cell and myoblast proliferation, expanding the cell pool available for muscle repair (in vitro and animal studies)
- May accelerate muscle repair after exercise-induced damage or injury (preclinical)
- Pro-survival, anti-apoptotic signaling reported in muscle and other cell types (preclinical)
- Preclinical cytoprotection: MGF pretreatment improved cardiac function after experimental myocardial infarction (mechanism distinct from IGF-1R, NOT via fibroblast growth factor receptor)
- Preclinical neuroprotection during cerebral ischemia
- PEGylation is intended to extend native MGF's very short half-life to allow less frequent research dosing
Pinealon: potential benefits
- Neuroprotection against oxidative and hypoxic stress (preclinical models)
- Antioxidant support - reduced oxidative DNA damage in aged neurons (in vitro)
- Cognitive and memory support in aging populations (small Russian clinical reports)
- Reduced neuronal apoptosis and support of dendritic-tree integrity in cell models
- Investigated for neuroprotection in Alzheimer's-model systems (preclinical)
Frequently asked
What's the difference between PEG-MGF and Pinealon?
PEG-MGF is a performance that peg-mgf is the pegylated form of mechano growth factor (mgf), a synthetic peptide corresponding to the c-terminal 24 amino acids of the unique e-domain of igf-1ec, an alternatively…. Pinealon is a nootropics that the proposed mechanism of pinealon is rooted in the khavinson school's broader theory of short-peptide tissue-specific bioregulation. the full theory is worth understanding because…. The two differ in mechanism, half-life (Native MGF: very short (minutes) due to rapid proteolysis. PEG-MGF: PEGylation is intended to extend this substantially (community estimates up to roughly 1 day), but there are no published human pharmacokinetic data to confirm a specific value. vs Not formally characterized in humans. Short regulatory peptides of this class are cleared from plasma within minutes; the Khavinson framework proposes durable downstream gene-expression effects that outlast the brief dosing window, which is the stated rationale for pulsed cycling rather than continuous dosing.), and typical dose range.
Which has the longer half-life, PEG-MGF or Pinealon?
PEG-MGF has a half-life of Native MGF: very short (minutes) due to rapid proteolysis. PEG-MGF: PEGylation is intended to extend this substantially (community estimates up to roughly 1 day), but there are no published human pharmacokinetic data to confirm a specific value.. Pinealon has a half-life of Not formally characterized in humans. Short regulatory peptides of this class are cleared from plasma within minutes; the Khavinson framework proposes durable downstream gene-expression effects that outlast the brief dosing window, which is the stated rationale for pulsed cycling rather than continuous dosing.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, PEG-MGF or Pinealon?
Lowest listed price on BodyHackGuide: PEG-MGF from $39.00, Pinealon from $45.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack PEG-MGF and Pinealon?
Stacking depends on mechanism overlap, safety profile, and goals. PEG-MGF and Pinealon should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Listings from the vendors we track. Prices change often, so check the vendor before you buy.
Before you buy PEG-MGF or Pinealon
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.