Oxytocin vs PT-141 (Bremelanotide)
Side-by-side comparison of Oxytocin and PT-141 (Bremelanotide): mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Oxytocin
PT-141 (Bremelanotide)
Oxytocin
Oxytocin is a nine-amino-acid cyclic peptide hormone (Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2) synthesized in magnocellular neurons of the hypothalamic paraventricular (PVN) and supraoptic nuclei (SON), then transported…
Lowest listed price: $34.99 across 4 listings
Full Oxytocin profilePT-141 (Bremelanotide)
PT-141 (bremelanotide) is a cyclic 7-amino-acid synthetic melanocortin receptor agonist that acts centrally in the brain — not peripherally on genital tissue — to improve sexual desire, arousal, and responsiveness. It is…
Lowest listed price: $34.99 across 5 listings
Full PT-141 (Bremelanotide) profileSide-by-side comparison
| Attribute | Oxytocin | PT-141 (Bremelanotide) |
|---|---|---|
| Category | Hormones & Endocrine (Non-GH) | Skin, Hair & Aesthetics |
| Research Stage | FDA-Approved | FDA Approved |
| Mechanism of Action | Oxytocin signals primarily through the oxytocin receptor (OXTR), a single G-protein-coupled receptor (GPCR) encoded on chromosome 3p25.3 in humans. OXTR couples predominantly to Gαq/11 signaling, activating phospholipase C, generating IP3 and DAG, raising… | Melanocortin Receptor Pharmacology PT-141 is a synthetic cyclic heptapeptide (Ac-Nle-cyclo[Asp-His-DPhe-Arg-Trp-Lys]-OH) that binds the melanocortin receptor family with the following selectivity profile: | Receptor | Primary Location | PT-141 Activity |… |
| Half-Life | ~1-6 minutes (plasma); central/behavioral effects outlast plasma clearance, typically ~30-120 minutes after intranasal dosing | ~2.7 hours |
| Typical Dose Range | — | 500–2,000 mcg (0.5–2 mg) per dose |
| Dosing Frequency | As needed (on-demand), timed 20-45 minutes before a target social/intimate window; research protocols have used up to 2-3x daily (commonly 24 IU twice daily) intranasally | As needed, 45 minutes before sexual activity; max once per 24 hours, max 8 doses/month |
| Administration | — | Subcutaneous |
| Side Effects | Oxytocin has a favorable safety profile at typical behavioral-research doses (intranasal 24-48 IU, subcutaneous 2-10 IU). Most side effects are mild and transient. Common (any oxytocin use): - Mild flushing or warm sensation - transient, reflecting modest… | Very Common (10% of users) - Nausea — By far the most common adverse effect, affecting approximately 40% of users in the RECONNECT trials. Usually mild-to-moderate, begins within 30-60 minutes of injection, resolves within 2-4 hours. Can be mitigated with… |
| Molecular Weight | 1007.19 g/mol | 1025.2 Da |
| Common Vial Sizes | — | 2mg, 10mg |
Price History
3 data points- Half Nattys
- Ion Peptide
- Disguised Alpha
Price History
5 data points- BM
- Half Nattys
- Ion Peptide
- BHG Labs
Oxytocin: potential benefits
- Social and emotional bonding (subtle, context-dependent)
- Situational social-anxiety relief
- Enhanced intimacy and post-orgasm bonding
- Labor induction and milk let-down (approved obstetric use)
- Trauma-focused therapy adjunct (investigational)
PT-141 (Bremelanotide): potential benefits
- Sexual desire enhancement
- HSDD treatment
- Erectile dysfunction (central mechanism)
- Non-hormonal approach
Frequently asked
What's the difference between Oxytocin and PT-141 (Bremelanotide)?
Oxytocin is a hormones & endocrine (non-gh) that oxytocin signals primarily through the oxytocin receptor (oxtr), a single g-protein-coupled receptor (gpcr) encoded on chromosome 3p25.3 in humans. oxtr couples predominantly to…. PT-141 (Bremelanotide) is a skin, hair & aesthetics that melanocortin receptor pharmacology pt-141 is a synthetic cyclic heptapeptide (ac-nle-cyclo[asp-his-dphe-arg-trp-lys]-oh) that binds the melanocortin receptor family with the…. The two differ in mechanism, half-life (~1-6 minutes (plasma); central/behavioral effects outlast plasma clearance, typically ~30-120 minutes after intranasal dosing vs ~2.7 hours), and typical dose range.
Which has the longer half-life, Oxytocin or PT-141 (Bremelanotide)?
Oxytocin has a half-life of ~1-6 minutes (plasma); central/behavioral effects outlast plasma clearance, typically ~30-120 minutes after intranasal dosing. PT-141 (Bremelanotide) has a half-life of ~2.7 hours. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Oxytocin or PT-141 (Bremelanotide)?
Lowest listed price on BodyHackGuide: Oxytocin from $34.99, PT-141 (Bremelanotide) from $34.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack Oxytocin and PT-141 (Bremelanotide)?
Stacking depends on mechanism overlap, safety profile, and goals. Oxytocin and PT-141 (Bremelanotide) should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.