Oxytocin vs N-Acetyl-Selank
Side-by-side comparison of Oxytocin and N-Acetyl-Selank: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Oxytocin
N-Acetyl-Selank
Oxytocin
Oxytocin is a nine-amino-acid cyclic peptide hormone (Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2) synthesized in magnocellular neurons of the hypothalamic paraventricular (PVN) and supraoptic nuclei (SON), then transported…
Lowest listed price: $34.99 across 4 listings
Full Oxytocin profileN-Acetyl-Selank
N-Acetyl-Selank is the N-terminally acetylated analog of Selank, a tuftsin-derived heptapeptide used intranasally for its reported anxiolytic and nootropic effects. The acetyl group is claimed to improve stability and…
Lowest listed price: $79.99 across 2 listings
Full N-Acetyl-Selank profileSide-by-side comparison
| Attribute | Oxytocin | N-Acetyl-Selank |
|---|---|---|
| Category | Hormones & Endocrine (Non-GH) | Cognitive |
| Research Stage | FDA-Approved | Preclinical (the N-acetyl analog has no dedicated studies); parent Selank has limited clinical use in Russia |
| Mechanism of Action | Oxytocin signals primarily through the oxytocin receptor (OXTR), a single G-protein-coupled receptor (GPCR) encoded on chromosome 3p25.3 in humans. OXTR couples predominantly to Gαq/11 signaling, activating phospholipase C, generating IP3 and DAG, raising… | N-Acetyl-Selank is the N-terminally acetylated analog of Selank, a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from the endogenous immunopeptide tuftsin (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro tail added to slow enzymatic breakdown.… |
| Half-Life | ~1-6 minutes (plasma); central/behavioral effects outlast plasma clearance, typically ~30-120 minutes after intranasal dosing | Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature. |
| Typical Dose Range | — | 100-900 mcg |
| Dosing Frequency | As needed (on-demand), timed 20-45 minutes before a target social/intimate window; research protocols have used up to 2-3x daily (commonly 24 IU twice daily) intranasally | Once or twice daily (intranasal); some advanced users split into 2-3 doses |
| Administration | — | — |
| Side Effects | Oxytocin has a favorable safety profile at typical behavioral-research doses (intranasal 24-48 IU, subcutaneous 2-10 IU). Most side effects are mild and transient. Common (any oxytocin use): - Mild flushing or warm sensation - transient, reflecting modest… | In short Russian clinical trials, parent Selank was generally well tolerated with no serious adverse effects reported [PMID:18454096]. Reported or plausible effects (largely extrapolated to the analog): mild nasal irritation or congestion from the spray,… |
| Molecular Weight | 1007.19 g/mol | ~793.9 g/mol (theoretical: Selank ~751.9 g/mol + N-terminal acetyl, ~+42). Approximate molecular formula C35H59N11O10. |
| Common Vial Sizes | — | — |
Price History
3 data points- Half Nattys
- Ion Peptide
- Disguised Alpha
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Oxytocin: potential benefits
- Social and emotional bonding (subtle, context-dependent)
- Situational social-anxiety relief
- Enhanced intimacy and post-orgasm bonding
- Labor induction and milk let-down (approved obstetric use)
- Trauma-focused therapy adjunct (investigational)
N-Acetyl-Selank: potential benefits
- Anxiolytic (calming) effects - the most-studied action of parent Selank, including a Russian clinical trial in generalized anxiety disorder [PMID:18454096]
- Nootropic / cognitive support - reported attention and memory benefits in rodent models, linked to BDNF changes [PMID:31625062]
- Stress resilience reported without the sedation, tolerance, or dependence typically seen with benzodiazepines (preclinical framing) [PMID:30255741]
- Possible support during withdrawal states (alcohol, opioid) in animal models [PMID:24913576][PMID:36322304]
- Claimed longer duration vs. plain Selank from N-terminal acetylation - a community/vendor claim not verified in published data
Frequently asked
What's the difference between Oxytocin and N-Acetyl-Selank?
Oxytocin is a hormones & endocrine (non-gh) that oxytocin signals primarily through the oxytocin receptor (oxtr), a single g-protein-coupled receptor (gpcr) encoded on chromosome 3p25.3 in humans. oxtr couples predominantly to…. N-Acetyl-Selank is a cognitive that n-acetyl-selank is the n-terminally acetylated analog of selank, a synthetic heptapeptide (thr-lys-pro-arg-pro-gly-pro) derived from the endogenous immunopeptide tuftsin…. The two differ in mechanism, half-life (~1-6 minutes (plasma); central/behavioral effects outlast plasma clearance, typically ~30-120 minutes after intranasal dosing vs Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature.), and typical dose range.
Which has the longer half-life, Oxytocin or N-Acetyl-Selank?
Oxytocin has a half-life of ~1-6 minutes (plasma); central/behavioral effects outlast plasma clearance, typically ~30-120 minutes after intranasal dosing. N-Acetyl-Selank has a half-life of Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Oxytocin or N-Acetyl-Selank?
Lowest listed price on BodyHackGuide: Oxytocin from $34.99, N-Acetyl-Selank from $79.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack Oxytocin and N-Acetyl-Selank?
Stacking depends on mechanism overlap, safety profile, and goals. Oxytocin and N-Acetyl-Selank should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.