NSI-189 vs Noopept
Side-by-side comparison of NSI-189 and Noopept: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
NSI-189
Noopept
NSI-189
NSI-189 is a novel synthetic compound developed by Neuralstem Inc. that stimulates neurogenesis in the human hippocampus. Phase 2 trials for major depressive disorder showed improvements in subjective cognitive function,…
Lowest listed price: $84.99 across 1 listing
Full NSI-189 profileNoopept
Noopept is the common brand and research name for N-phenylacetyl-L-prolylglycine ethyl ester (GVS-111; INN omberacetam), a small dipeptide nootropic developed in the 1990s at the Russian Academy of Medical Sciences'…
Lowest listed price: $49.99 across 1 listing
Full Noopept profileSide-by-side comparison
| Attribute | NSI-189 | Noopept |
|---|---|---|
| Category | Nootropics | Nootropics |
| Research Stage | Preclinical | Preclinical |
| Mechanism of Action | NSI-189 stimulates proliferation and differentiation of human hippocampal neural stem cells through a mechanism distinct from BDNF or classical antidepressants. Rodent studies show a 20% increase in hippocampal volume after 6 weeks of treatment. It is not a… | Noopept's mechanism of action is multifaceted and — despite decades of research — incompletely understood. Several convergent pathways have been proposed, each supported by preclinical data but none definitively established as the primary driver of its… |
| Half-Life | — | — |
| Typical Dose Range | — | — |
| Dosing Frequency | — | — |
| Administration | — | — |
| Side Effects | Mild GI discomfort, injection site reaction (if injected), headache. Very well-tolerated. Rare: anxiety or insomnia at high doses. | Noopept is generally well tolerated in the Russian clinical literature, with side effects that are typically mild and transient. However, "well tolerated in Russian open-label trials" is a weaker safety claim than the rigorous multi-phase trial data underlying… |
| Molecular Weight | 313.36 g/mol | 318.37 g/mol |
| Common Vial Sizes | — | — |
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2 data pointsNSI-189: potential benefits
- Increased hippocampal neurogenesis
- Antidepressant effects
- Enhanced synaptic plasticity
- Improved cognitive function
- Long-lasting mood improvement
- Potential PTSD treatment
Noopept: potential benefits
- Memory enhancement
- BDNF/NGF upregulation
- Neuroprotection
- Focus and learning speed
- Anxiety reduction (moderate)
- Anti-amyloid properties
Frequently asked
What's the difference between NSI-189 and Noopept?
NSI-189 is a nootropics that nsi-189 stimulates proliferation and differentiation of human hippocampal neural stem cells through a mechanism distinct from bdnf or classical antidepressants. rodent studies show…. Noopept is a nootropics that noopept's mechanism of action is multifaceted and — despite decades of research — incompletely understood. several convergent pathways have been proposed, each supported by…. The two differ in mechanism, half-life (not reported vs not reported), and typical dose range.
Which has the longer half-life, NSI-189 or Noopept?
NSI-189 has a half-life of not reported. Noopept has a half-life of not reported. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, NSI-189 or Noopept?
Lowest listed price on BodyHackGuide: NSI-189 from $84.99, Noopept from $49.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack NSI-189 and Noopept?
Stacking depends on mechanism overlap, safety profile, and goals. NSI-189 and Noopept should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Listings from the vendors we track. Prices change often, so check the vendor before you buy.
Before you buy NSI-189 or Noopept
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.