Glycine vs N-Acetyl-Selank
Side-by-side comparison of Glycine and N-Acetyl-Selank: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Glycine
N-Acetyl-Selank
Glycine
Glycine is the simplest amino acid—a single hydrogen atom replacing the typical side chain found in other proteinogenic amino acids—yet it performs an wide range of biological functions. Despite being classified as…
No vendor price on file.
Full Glycine profileN-Acetyl-Selank
N-Acetyl-Selank is the N-terminally acetylated analog of Selank, a tuftsin-derived heptapeptide used intranasally for its reported anxiolytic and nootropic effects. The acetyl group is claimed to improve stability and…
Lowest listed price: $79.99 across 2 listings
Full N-Acetyl-Selank profileSide-by-side comparison
| Attribute | Glycine | N-Acetyl-Selank |
|---|---|---|
| Category | Foundational | Cognitive |
| Research Stage | Preclinical | Preclinical (the N-acetyl analog has no dedicated studies); parent Selank has limited clinical use in Russia |
| Mechanism of Action | Glycine acts through multiple distinct and non-redundant mechanisms, explaining its extraordinarily broad range of biological effects. Understanding these mechanisms clarifies when supplementation is likely to produce clinically meaningful benefit versus when… | N-Acetyl-Selank is the N-terminally acetylated analog of Selank, a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from the endogenous immunopeptide tuftsin (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro tail added to slow enzymatic breakdown.… |
| Half-Life | — | Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature. |
| Typical Dose Range | — | 100-900 mcg |
| Dosing Frequency | — | Once or twice daily (intranasal); some advanced users split into 2-3 doses |
| Administration | — | — |
| Side Effects | Glycine has an exceptional safety profile across extensive clinical use. Doses up to 60 g daily have been used in schizophrenia trials without systematic serious adverse effects. For typical supplementation doses (3-15 g daily), side effects are uncommon and… | In short Russian clinical trials, parent Selank was generally well tolerated with no serious adverse effects reported [PMID:18454096]. Reported or plausible effects (largely extrapolated to the analog): mild nasal irritation or congestion from the spray,… |
| Molecular Weight | — | ~793.9 g/mol (theoretical: Selank ~751.9 g/mol + N-terminal acetyl, ~+42). Approximate molecular formula C35H59N11O10. |
| Common Vial Sizes | — | — |
Price tracking
Glycine: potential benefits
- No structured benefit list published.
N-Acetyl-Selank: potential benefits
- Anxiolytic (calming) effects - the most-studied action of parent Selank, including a Russian clinical trial in generalized anxiety disorder [PMID:18454096]
- Nootropic / cognitive support - reported attention and memory benefits in rodent models, linked to BDNF changes [PMID:31625062]
- Stress resilience reported without the sedation, tolerance, or dependence typically seen with benzodiazepines (preclinical framing) [PMID:30255741]
- Possible support during withdrawal states (alcohol, opioid) in animal models [PMID:24913576][PMID:36322304]
- Claimed longer duration vs. plain Selank from N-terminal acetylation - a community/vendor claim not verified in published data
Frequently asked
What's the difference between Glycine and N-Acetyl-Selank?
Glycine is a foundational that glycine acts through multiple distinct and non-redundant mechanisms, explaining its extraordinarily broad range of biological effects. understanding these mechanisms clarifies when…. N-Acetyl-Selank is a cognitive that n-acetyl-selank is the n-terminally acetylated analog of selank, a synthetic heptapeptide (thr-lys-pro-arg-pro-gly-pro) derived from the endogenous immunopeptide tuftsin…. The two differ in mechanism, half-life (not reported vs Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature.), and typical dose range.
Which has the longer half-life, Glycine or N-Acetyl-Selank?
Glycine has a half-life of not reported. N-Acetyl-Selank has a half-life of Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Can you stack Glycine and N-Acetyl-Selank?
Stacking depends on mechanism overlap, safety profile, and goals. Glycine and N-Acetyl-Selank should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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