FOXO4-DRI vs NAD+
Side-by-side comparison of FOXO4-DRI and NAD+: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
FOXO4-DRI
NAD+
FOXO4-DRI
FOXO4-DRI is a synthetic 34-amino-acid D-retro-inverso peptide designed to disrupt the interaction between the FOXO4 transcription factor and p53, with the specific goal of inducing apoptosis selectively in senescent…
Lowest listed price: $119.00 across 4 listings
Full FOXO4-DRI profileNAD+
NAD+ (nicotinamide adenine dinucleotide, oxidized form) is a pyridine dinucleotide coenzyme essential to energy metabolism, DNA repair via PARP enzymes, sirtuin-mediated gene regulation, and calcium signaling via CD38.…
Lowest listed price: $25.00 across 11 listings
Full NAD+ profileSide-by-side comparison
| Attribute | FOXO4-DRI | NAD+ |
|---|---|---|
| Category | Recovery | Longevity |
| Research Stage | Preclinical | Phase II |
| Mechanism of Action | FOXO4-DRI works by disrupting the protein-protein interaction between FOXO4 (Forkhead box O4) and p53 in senescent cells, which releases p53 from nuclear sequestration and allows it to translocate to the mitochondrial outer membrane where it triggers the… | Redox Cofactor Function NAD+ serves as the primary electron acceptor in catabolic reactions (glycolysis, TCA cycle, fatty acid oxidation), cycling between its oxidized (NAD+) and reduced (NADH) forms. This fundamental energy metabolism role means every cell… |
| Half-Life | Not established in humans; no published human pharmacokinetic data. The D-retro-inverso construction confers resistance to human proteases, which in preclinical models extends the in vivo half-life from minutes (typical for comparable L-amino-acid peptides) to hours ([Baar et al., 2017](https://pubmed.ncbi.nlm.nih.gov/28340339/)). | Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent |
| Typical Dose Range | No validated human dose. Self-report: 2-15 mg SC per dose (typically 5 mg), pulsed 3-7 days every 2-6 months; no human PK data. The 5 mg/kg figure seen in some sources is a mouse research dose (Baar 2017), not a human dose. | Oral precursors: NR 300-2,000 mg/day, NMN 250-900 mg/day, NAM 500-1,500 mg/day; IV NAD+ 500-1,500 mg per session. |
| Dosing Frequency | — | Oral precursors once daily (higher doses split AM/midday); IV NAD+ weekly-to-monthly at clinics. |
| Administration | — | Oral (precursors), Intravenous, Intramuscular, Subcutaneous |
| Side Effects | The side effect profile of FOXO4-DRI in humans is not documented because no clinical trials have been conducted. Rodent studies from the Baar et al. 2017 publication and subsequent work report generally acceptable tolerability at doses producing senolytic… | Nicotinamide Riboside (NR) NR has the best-characterized safety profile of the NAD+ precursors. Across published RCTs at 1,000-2,000 mg/day for up to 12 weeks, adverse effects have been mild and uncommon: - Gastrointestinal upset (5-10% of users) - Mild… |
| Molecular Weight | 3587.0 g/mol | 663.4 g/mol (NAD+); NR 255.3 g/mol; NMN 334.2 g/mol; NAM 122.1 g/mol |
| Common Vial Sizes | — | 100mg, 250mg, 500mg |
Price History
4 data points- Half Nattys
- Ion Peptide
- Disguised Alpha
- LB
Price History
4 data points- OF
- BM
- Half Nattys
- Ion Peptide
- BHG Labs
FOXO4-DRI: potential benefits
- Selective senescent cell clearance
- Potential reversal of aging markers
- Reduced chronic inflammation
- Improved tissue function
- Hair regrowth (animal studies)
- Organ rejuvenation potential
NAD+: potential benefits
- Restores age-associated NAD+ decline — 50% loss between young and older adulthood
- Increases peripheral blood NAD+ by up to 142% at 1,000 mg NR daily (Elhassan 2019)
- Supports sirtuin-mediated gene regulation and PARP-mediated DNA repair
- Improves muscle insulin sensitivity in prediabetic postmenopausal women (Yoshino 2021)
- Increases aerobic performance in amateur runners at 300-600 mg NMN (Liao 2021)
- Reduces inflammatory cytokines (IL-6, TNF-alpha) in middle-aged/elderly (Martens, Elhassan)
- Brain NAD+ elevation demonstrated in Parkinson trial (Brakedal 2022)
- Excellent safety profile at evidence-supported doses (500-2000 mg/day NR)
Frequently asked
What's the difference between FOXO4-DRI and NAD+?
FOXO4-DRI is a recovery that foxo4-dri works by disrupting the protein-protein interaction between foxo4 (forkhead box o4) and p53 in senescent cells, which releases p53 from nuclear sequestration and allows…. NAD+ is a longevity that redox cofactor function nad+ serves as the primary electron acceptor in catabolic reactions (glycolysis, tca cycle, fatty acid oxidation), cycling between its oxidized (nad+) and…. The two differ in mechanism, half-life (Not established in humans; no published human pharmacokinetic data. The D-retro-inverso construction confers resistance to human proteases, which in preclinical models extends the in vivo half-life from minutes (typical for comparable L-amino-acid peptides) to hours ([Baar et al., 2017](https://pubmed.ncbi.nlm.nih.gov/28340339/)). vs Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent), and typical dose range.
Which has the longer half-life, FOXO4-DRI or NAD+?
FOXO4-DRI has a half-life of Not established in humans; no published human pharmacokinetic data. The D-retro-inverso construction confers resistance to human proteases, which in preclinical models extends the in vivo half-life from minutes (typical for comparable L-amino-acid peptides) to hours ([Baar et al., 2017](https://pubmed.ncbi.nlm.nih.gov/28340339/)).. NAD+ has a half-life of Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, FOXO4-DRI or NAD+?
Lowest listed price on BodyHackGuide: FOXO4-DRI from $119.00, NAD+ from $25.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack FOXO4-DRI and NAD+?
Stacking depends on mechanism overlap, safety profile, and goals. FOXO4-DRI and NAD+ should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.