Epithalon vs Glutathione
Side-by-side comparison of Epithalon and Glutathione: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Epithalon
Glutathione
Epithalon
Epithalon (also spelled Epitalon, sequence Ala-Glu-Asp-Gly / AEDG) is a synthetic tetrapeptide designed by Prof. Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology in the 1980s as a…
Lowest listed price: $34.99 across 4 listings
Full Epithalon profileGlutathione
Glutathione is the body's most abundant intracellular antioxidant — a three-amino-acid peptide made of glutamate, cysteine, and glycine (Glu-Cys-Gly), present in millimolar concentrations inside every cell of your body.…
Lowest listed price: $29.00 across 8 listings
Full Glutathione profileSide-by-side comparison
| Attribute | Epithalon | Glutathione |
|---|---|---|
| Category | Longevity & Cellular Health | Recovery |
| Research Stage | Preclinical (Western standards); Used clinically in Russian gerontological medicine | Clinical |
| Mechanism of Action | Epithalon (AEDG; Ala-Glu-Asp-Gly) is a synthetic tetrapeptide modeled on the pineal polypeptide preparation epithalamin. Its proposed mechanism spans several parallel pathways. The human-relevant evidence is strongest for melatonin/circadian effects; the… | Glutathione's mechanisms extend far beyond the simple "antioxidant" label that dominates popular marketing. Understanding these mechanisms matters because they determine where supplementation is likely to help and where it is unlikely to make any difference.… |
| Half-Life | Not well characterized in humans. As a small tetrapeptide, AEDG is expected to have a very short plasma half-life (on the order of minutes), while downstream gene-expression and circadian effects are thought to persist considerably longer. Any specific half-life figure should be treated as an unvalidated estimate. | Short: on the order of minutes for intravenous glutathione (intact GSH is cleared rapidly from plasma and cellular uptake of intact GSH is limited). Oral bioavailability is low, so tissue glutathione levels depend mainly on endogenous synthesis from cysteine, glycine, and glutamate rather than on the half-life of administered GSH. |
| Typical Dose Range | 5000-10000 mcg (5-10 mg) subcutaneous daily for 10-20 day cycles; typically repeated 1-2 times per year in anti-aging protocols | 250 mg - 1000 mg daily (oral, IV, or nebulized) |
| Dosing Frequency | Once daily for 10–20 day cycles | — |
| Administration | Subcutaneous | — |
| Side Effects | Expected / benign - Mild injection-site reaction — redness, slight tenderness, occasional small bruise. Resolves within 24-48 hours. - Enhanced, more vivid dreams in the first week of a cycle — consistent with melatonin rise. - Deeper sleep onset and feeling… | Glutathione has an excellent overall safety profile at typical supplement and medical doses. Serious adverse events are rare, and most side effects are mild and self-limited. That said, "safe" is not "sideeffect-free," and specific formulations and routes… |
| Molecular Weight | 390.3 Da | 307.32 g/mol (C10H17N3O6S) |
| Common Vial Sizes | 10mg, 50mg | — |
Price History
4 data points- Half Nattys
- Disguised Alpha
- LB
Price History
4 data points- Half Nattys
- Ion Peptide
- BHG Labs
Epithalon: potential benefits
- Telomerase activation and telomere elongation (human cell culture)
- Normalization of circadian melatonin rhythm (human data from epithalamin, the parent pineal preparation)
- Improved sleep consolidation and circadian regularity (subjective)
- Modest life-span effects in rodents (mainly maximum / late-survivor lifespan; no change in mean lifespan)
- Reduced incidence of specific tumors (e.g. ~6-fold fewer leukemias in SHR mice); no change in total tumor incidence
- Reduced chromosomal aberrations in aged rodent tissue
- Site-specific DNA / chromatin binding (proposed epigenetic modulation)
- Association with lower mortality in an elderly cardiovascular cohort (epithalamin RCT, Korkushko 2011)
Glutathione: potential benefits
- Powerful antioxidant protection
- Liver detoxification support
- Immune system enhancement
- Skin brightening and anti-aging
- Heavy metal chelation support
- Reduced oxidative stress
Frequently asked
What's the difference between Epithalon and Glutathione?
Epithalon is a longevity & cellular health that epithalon (aedg; ala-glu-asp-gly) is a synthetic tetrapeptide modeled on the pineal polypeptide preparation epithalamin. its proposed mechanism spans several parallel pathways. the…. Glutathione is a recovery that glutathione's mechanisms extend far beyond the simple "antioxidant" label that dominates popular marketing. understanding these mechanisms matters because they determine where…. The two differ in mechanism, half-life (Not well characterized in humans. As a small tetrapeptide, AEDG is expected to have a very short plasma half-life (on the order of minutes), while downstream gene-expression and circadian effects are thought to persist considerably longer. Any specific half-life figure should be treated as an unvalidated estimate. vs Short: on the order of minutes for intravenous glutathione (intact GSH is cleared rapidly from plasma and cellular uptake of intact GSH is limited). Oral bioavailability is low, so tissue glutathione levels depend mainly on endogenous synthesis from cysteine, glycine, and glutamate rather than on the half-life of administered GSH.), and typical dose range.
Which has the longer half-life, Epithalon or Glutathione?
Epithalon has a half-life of Not well characterized in humans. As a small tetrapeptide, AEDG is expected to have a very short plasma half-life (on the order of minutes), while downstream gene-expression and circadian effects are thought to persist considerably longer. Any specific half-life figure should be treated as an unvalidated estimate.. Glutathione has a half-life of Short: on the order of minutes for intravenous glutathione (intact GSH is cleared rapidly from plasma and cellular uptake of intact GSH is limited). Oral bioavailability is low, so tissue glutathione levels depend mainly on endogenous synthesis from cysteine, glycine, and glutamate rather than on the half-life of administered GSH.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Epithalon or Glutathione?
Lowest listed price on BodyHackGuide: Epithalon from $34.99, Glutathione from $29.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack Epithalon and Glutathione?
Stacking depends on mechanism overlap, safety profile, and goals. Epithalon and Glutathione should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.