DSIP (Delta Sleep-Inducing Peptide) vs Semax
Side-by-side comparison of DSIP (Delta Sleep-Inducing Peptide) and Semax: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
DSIP (Delta Sleep-Inducing Peptide)
Semax
DSIP (Delta Sleep-Inducing Peptide)
Delta sleep-inducing peptide (DSIP) is a nonapeptide — a 9-amino-acid neuropeptide with sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE, 848 Da molecular weight) — first isolated in 1977 from the cerebral venous…
Lowest listed price: $34.99 across 11 listings
Full DSIP (Delta Sleep-Inducing Peptide) profileSemax
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro, MEHFPGP, 813 Da molecular weight) developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1980s. The compound is derived…
Lowest listed price: $32.90 across 5 listings
Full Semax profileSide-by-side comparison
| Attribute | DSIP (Delta Sleep-Inducing Peptide) | Semax |
|---|---|---|
| Category | Cognition, Mood & Neuroprotection | Nootropics |
| Research Stage | Research Use Only | Approved (Russia, since mid-1990s for stroke and cognitive disorders) |
| Mechanism of Action | Primary Mechanism: Uncharacterized Direct Receptor Binding After more than four decades of research, DSIP's primary molecular target remains unknown. No specific receptor has been cloned, characterized, or reproducibly identified as the primary binding site… | Primary Mechanism: Multi-Pathway Neurotrophic Activation Semax produces its effects through coordinated activation of multiple neurotrophic, neurotransmitter, and neuroprotective pathways. Unlike conventional nootropics that target a single system (modafinil… |
| Half-Life | ~7-15 minutes (IV; plasma clearance is rapid, though subjective sleep effects can outlast measurable blood levels) | ~2-3 minutes plasma half-life (functional neurological effects persist 12-24 hours due to BDNF/NGF gene expression changes) |
| Typical Dose Range | 100–300 mcg per injection | 100-900 mcg intranasal daily (0.1% solution: 2-3 drops per nostril 2-3x daily); 1% solution used for acute stroke in Russian clinical protocols |
| Dosing Frequency | Once daily, 30–60 minutes before bedtime | Intranasal 1–3 times daily |
| Administration | Subcutaneous, Intramuscular, Intranasal | Intranasal |
| Side Effects | Overall Safety Profile DSIP has one of the cleanest safety profiles of any peptide in the research chemical space. In 40+ years of research and clinical use, no serious adverse events have been reported in controlled trials or large case series. The compound… | Overall Safety Profile Semax has an excellent safety profile across 20+ years of Russian clinical use. In acute stroke trials, cognitive studies, and pediatric applications, Semax has demonstrated consistent tolerability with minimal adverse event burden. This… |
| Molecular Weight | 848.8 Da | 813.9 Da |
| Common Vial Sizes | 2mg, 5mg | 5mg, 10mg |
Price History
8 data points- BM
- Half Nattys
- LB
- Ion Peptide
- OF
- Disguised Alpha
- BHG Labs
Price History
5 data points- OF
- Half Nattys
- Ion Peptide
- BHG Labs
DSIP (Delta Sleep-Inducing Peptide): potential benefits
- Sleep quality support
- Stress reduction
- Cortisol/HPA modulation
- Alcohol & opioid withdrawal support
- Circadian regulation
Semax: potential benefits
- Rapid BDNF/TrkB upregulation in the hippocampus, supporting synaptic plasticity and learning (PMID: 16996037)
- Neuroprotective, immunomodulatory gene-expression changes in focal cerebral ischemia (middle cerebral artery occlusion) models (PMID: 28255762)
- Cognitive enhancement including improved attention, working memory, and processing speed
- Dopaminergic modulation that may support motivation and executive function (preclinical data)
- Stroke recovery facilitation - accelerated functional recovery and improved Barthel Index in ischemic stroke patients; approved in Russia for ischemic stroke (PMID: 29798983)
- Anxiolytic and anti-asthenic effects reported in Russian clinical use, attributed to neurotrophic and monoaminergic modulation
- Non-addictive cognitive support without tolerance development or withdrawal at standard doses
Frequently asked
What's the difference between DSIP (Delta Sleep-Inducing Peptide) and Semax?
DSIP (Delta Sleep-Inducing Peptide) is a cognition, mood & neuroprotection that primary mechanism: uncharacterized direct receptor binding after more than four decades of research, dsip's primary molecular target remains unknown. no specific receptor has been…. Semax is a nootropics that primary mechanism: multi-pathway neurotrophic activation semax produces its effects through coordinated activation of multiple neurotrophic, neurotransmitter, and neuroprotective…. The two differ in mechanism, half-life (~7-15 minutes (IV; plasma clearance is rapid, though subjective sleep effects can outlast measurable blood levels) vs ~2-3 minutes plasma half-life (functional neurological effects persist 12-24 hours due to BDNF/NGF gene expression changes)), and typical dose range.
Which has the longer half-life, DSIP (Delta Sleep-Inducing Peptide) or Semax?
DSIP (Delta Sleep-Inducing Peptide) has a half-life of ~7-15 minutes (IV; plasma clearance is rapid, though subjective sleep effects can outlast measurable blood levels). Semax has a half-life of ~2-3 minutes plasma half-life (functional neurological effects persist 12-24 hours due to BDNF/NGF gene expression changes). Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, DSIP (Delta Sleep-Inducing Peptide) or Semax?
Lowest listed price on BodyHackGuide: DSIP (Delta Sleep-Inducing Peptide) from $34.99, Semax from $32.90. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack DSIP (Delta Sleep-Inducing Peptide) and Semax?
Stacking depends on mechanism overlap, safety profile, and goals. DSIP (Delta Sleep-Inducing Peptide) and Semax should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.