DSIP (Delta Sleep-Inducing Peptide) vs Selank
Side-by-side comparison of DSIP (Delta Sleep-Inducing Peptide) and Selank: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
DSIP (Delta Sleep-Inducing Peptide)
Selank
DSIP (Delta Sleep-Inducing Peptide)
Delta sleep-inducing peptide (DSIP) is a nonapeptide — a 9-amino-acid neuropeptide with sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE, 848 Da molecular weight) — first isolated in 1977 from the cerebral venous…
Lowest listed price: $34.99 across 11 listings
Full DSIP (Delta Sleep-Inducing Peptide) profileSelank
Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro, 750 Da molecular weight) developed in the 1990s at the Institute of Molecular Genetics of the Russian Academy of Sciences as a synthetic analog of tuftsin…
Lowest listed price: $25.00 across 6 listings
Full Selank profileSide-by-side comparison
| Attribute | DSIP (Delta Sleep-Inducing Peptide) | Selank |
|---|---|---|
| Category | Cognition, Mood & Neuroprotection | Nootropics |
| Research Stage | Research Use Only | Approved (Russia, as anxiolytic and nootropic medication) |
| Mechanism of Action | Primary Mechanism: Uncharacterized Direct Receptor Binding After more than four decades of research, DSIP's primary molecular target remains unknown. No specific receptor has been cloned, characterized, or reproducibly identified as the primary binding site… | Primary Mechanism: Multi-System Neurochemical Modulation Selank does not have a single clean receptor-binding mechanism. Unlike benzodiazepines (GABA-A positive allosteric modulators), SSRIs (serotonin reuptake inhibition), or buspirone (5-HT1A partial… |
| Half-Life | ~7-15 minutes (IV; plasma clearance is rapid, though subjective sleep effects can outlast measurable blood levels) | ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation) |
| Typical Dose Range | 100–300 mcg per injection | 250-750 mcg intranasal daily (0.15% solution: 2-3 drops per nostril 2-3x daily); typical course is 14-21 days |
| Dosing Frequency | Once daily, 30–60 minutes before bedtime | Intranasal 1–3 times daily |
| Administration | Subcutaneous, Intramuscular, Intranasal | Intranasal |
| Side Effects | Overall Safety Profile DSIP has one of the cleanest safety profiles of any peptide in the research chemical space. In 40+ years of research and clinical use, no serious adverse events have been reported in controlled trials or large case series. The compound… | Overall Safety Profile Selank has one of the best safety profiles in the anxiolytic space. Over 15+ years of Russian clinical use and research, the compound has been associated with essentially no serious adverse events at therapeutic doses. This compares… |
| Molecular Weight | 848.8 Da | 751.9 Da |
| Common Vial Sizes | 2mg, 5mg | 5mg, 10mg |
Price History
8 data points- BM
- Half Nattys
- LB
- Ion Peptide
- OF
- Disguised Alpha
- BHG Labs
Price History
5 data points- OF
- Half Nattys
- Ion Peptide
- BHG Labs
DSIP (Delta Sleep-Inducing Peptide): potential benefits
- Sleep quality support
- Stress reduction
- Cortisol/HPA modulation
- Alcohol & opioid withdrawal support
- Circadian regulation
Selank: potential benefits
- Anxiolytic effects comparable to benzodiazepines but without sedation or dependence in Russian clinical trials (PMID: 18454096)
- Positive allosteric modulation of brain GABA receptors through a non-benzodiazepine binding site (PMID: 30255741)
- Immunomodulation via Th1/Th2 cytokine balance and IL-6 regulation in patients with anxiety-asthenic disorders (PMID: 18577961)
- Cognitive and memory support linked to BDNF upregulation in the hippocampus in preclinical models (PMID: 18841804)
- Modulation of the endogenous enkephalin-opioid system supporting mood and stress tolerance (PMID: 22550852)
- Anti-inflammatory and adaptogenic effects through normalization of stress-induced cytokine dysregulation
- Non-addictive anxiolytic profile - no tolerance, withdrawal, or dependence reported across years of Russian clinical use
Frequently asked
What's the difference between DSIP (Delta Sleep-Inducing Peptide) and Selank?
DSIP (Delta Sleep-Inducing Peptide) is a cognition, mood & neuroprotection that primary mechanism: uncharacterized direct receptor binding after more than four decades of research, dsip's primary molecular target remains unknown. no specific receptor has been…. Selank is a nootropics that primary mechanism: multi-system neurochemical modulation selank does not have a single clean receptor-binding mechanism. unlike benzodiazepines (gaba-a positive allosteric…. The two differ in mechanism, half-life (~7-15 minutes (IV; plasma clearance is rapid, though subjective sleep effects can outlast measurable blood levels) vs ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation)), and typical dose range.
Which has the longer half-life, DSIP (Delta Sleep-Inducing Peptide) or Selank?
DSIP (Delta Sleep-Inducing Peptide) has a half-life of ~7-15 minutes (IV; plasma clearance is rapid, though subjective sleep effects can outlast measurable blood levels). Selank has a half-life of ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation). Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, DSIP (Delta Sleep-Inducing Peptide) or Selank?
Lowest listed price on BodyHackGuide: DSIP (Delta Sleep-Inducing Peptide) from $34.99, Selank from $25.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack DSIP (Delta Sleep-Inducing Peptide) and Selank?
Stacking depends on mechanism overlap, safety profile, and goals. DSIP (Delta Sleep-Inducing Peptide) and Selank should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.