DSIP (Delta Sleep-Inducing Peptide) vs Cortagen
Side-by-side comparison of DSIP (Delta Sleep-Inducing Peptide) and Cortagen: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
DSIP (Delta Sleep-Inducing Peptide)
Cortagen
DSIP (Delta Sleep-Inducing Peptide)
Delta sleep-inducing peptide (DSIP) is a nonapeptide — a 9-amino-acid neuropeptide with sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE, 848 Da molecular weight) — first isolated in 1977 from the cerebral venous…
Lowest listed price: $34.99 across 11 listings
Full DSIP (Delta Sleep-Inducing Peptide) profileCortagen
Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) from the Khavinson bioregulator family developed at the St. Petersburg Institute of Bioregulation and Gerontology. It is organ-targeted to cardiac and coronary…
Lowest listed price: $79.00 across 1 listing
Full Cortagen profileSide-by-side comparison
| Attribute | DSIP (Delta Sleep-Inducing Peptide) | Cortagen |
|---|---|---|
| Category | Cognition, Mood & Neuroprotection | Longevity |
| Research Stage | Research Use Only | Preclinical |
| Mechanism of Action | Primary Mechanism: Uncharacterized Direct Receptor Binding After more than four decades of research, DSIP's primary molecular target remains unknown. No specific receptor has been cloned, characterized, or reproducibly identified as the primary binding site… | Cortagen is a synthetic tetrapeptide, Ala-Glu-Asp-Pro (AEDP), created by the Khavinson group through directed synthesis based on the amino-acid composition of Cortexin, a polypeptide complex extracted from the cerebral cortex [PMID:15159690]. It is a… |
| Half-Life | ~7-15 minutes (IV; plasma clearance is rapid, though subjective sleep effects can outlast measurable blood levels) | Unknown (tetrapeptide; estimated <4 hours) |
| Typical Dose Range | 100–300 mcg per injection | — |
| Dosing Frequency | Once daily, 30–60 minutes before bedtime | once_daily |
| Administration | Subcutaneous, Intramuscular, Intranasal | Subcutaneous, Intramuscular |
| Side Effects | Overall Safety Profile DSIP has one of the cleanest safety profiles of any peptide in the research chemical space. In 40+ years of research and clinical use, no serious adverse events have been reported in controlled trials or large case series. The compound… | — |
| Molecular Weight | 848.8 Da | 430.4 g/mol (C17H26N4O9, PubChem CID 18439621) |
| Common Vial Sizes | 2mg, 5mg | 20 |
Price History
8 data points- BM
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- Ion Peptide
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- Disguised Alpha
- BHG Labs
Price tracking
DSIP (Delta Sleep-Inducing Peptide): potential benefits
- Sleep quality support
- Stress reduction
- Cortisol/HPA modulation
- Alcohol & opioid withdrawal support
- Circadian regulation
Cortagen: potential benefits
- Peripheral nerve repair - accelerated axon regeneration and faster nerve-conduction recovery after injury in rat models [PMID:11276314; PMID:12134478]
- Neuroprotection and antioxidant activity in the cerebral cortex and in chronic brain-ischemia models (preclinical) [PMID:18239817; PMID:21476278]
- CNS/cognitive support as the synthetic short-peptide analog of the cortex-derived Russian drug Cortexin
- Anti-aging chromatin remodeling - reactivation of age-silenced ribosomal genes in lymphocytes from elderly donors [PMID:15085253; PMID:37042594]
- Mild immune-signaling modulation (IL-2 expression), generally weaker than Vilon or Epithalon [PMID:12447482; PMID:16224591]
- Longevity-protocol stacking as one of the Khavinson short-peptide bioregulators (commonly paired with Epitalon or Pinealon)
Frequently asked
What's the difference between DSIP (Delta Sleep-Inducing Peptide) and Cortagen?
DSIP (Delta Sleep-Inducing Peptide) is a cognition, mood & neuroprotection that primary mechanism: uncharacterized direct receptor binding after more than four decades of research, dsip's primary molecular target remains unknown. no specific receptor has been…. Cortagen is a longevity that cortagen is a synthetic tetrapeptide, ala-glu-asp-pro (aedp), created by the khavinson group through directed synthesis based on the amino-acid composition of cortexin, a…. The two differ in mechanism, half-life (~7-15 minutes (IV; plasma clearance is rapid, though subjective sleep effects can outlast measurable blood levels) vs Unknown (tetrapeptide; estimated <4 hours)), and typical dose range.
Which has the longer half-life, DSIP (Delta Sleep-Inducing Peptide) or Cortagen?
DSIP (Delta Sleep-Inducing Peptide) has a half-life of ~7-15 minutes (IV; plasma clearance is rapid, though subjective sleep effects can outlast measurable blood levels). Cortagen has a half-life of Unknown (tetrapeptide; estimated <4 hours). Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, DSIP (Delta Sleep-Inducing Peptide) or Cortagen?
Lowest listed price on BodyHackGuide: DSIP (Delta Sleep-Inducing Peptide) from $34.99, Cortagen from $79.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack DSIP (Delta Sleep-Inducing Peptide) and Cortagen?
Stacking depends on mechanism overlap, safety profile, and goals. DSIP (Delta Sleep-Inducing Peptide) and Cortagen should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.