DMHA vs NAD+
Side-by-side comparison of DMHA and NAD+: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
DMHA
NAD+
DMHA
DMHA (octodrine) - chemically 2-amino-6-methylheptane, also sold as 2-aminoisoheptane or 1,5-dimethylhexylamine - is an aliphatic-amine central nervous system stimulant and a close structural analog of DMAA…
No vendor price on file.
Full DMHA profileNAD+
NAD+ (nicotinamide adenine dinucleotide, oxidized form) is a pyridine dinucleotide coenzyme essential to energy metabolism, DNA repair via PARP enzymes, sirtuin-mediated gene regulation, and calcium signaling via CD38.…
Lowest listed price: $25.00 across 11 listings
Full NAD+ profileSide-by-side comparison
| Attribute | DMHA | NAD+ |
|---|---|---|
| Category | Energy & Performance | Longevity |
| Research Stage | Historical pharmaceutical; no modern clinical trials | Phase II |
| Mechanism of Action | DMHA (octodrine; 2-amino-6-methylheptane / 1,5-dimethylhexylamine) is a simple aliphatic amine that behaves as an indirect sympathomimetic - structurally and pharmacologically a close cousin of DMAA (1,3-dimethylamylamine). Agents in this class raise synaptic… | Redox Cofactor Function NAD+ serves as the primary electron acceptor in catabolic reactions (glycolysis, TCA cycle, fatty acid oxidation), cycling between its oxidized (NAD+) and reduced (NADH) forms. This fundamental energy metabolism role means every cell… |
| Half-Life | Not formally characterized in humans. After ingestion, octodrine is rapidly metabolized to heptaminol, which becomes the predominant compound detected in blood and urine within hours [PMID:39401652]. Users commonly report perceptible stimulant effects lasting roughly 3-6 hours, but this is anecdotal rather than measured pharmacokinetics. | Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent |
| Typical Dose Range | 75-200 mg per dose (anecdotal pre-workout range; ~75,000-200,000 mcg). Historical pharmaceutical unit dose was 8-33 mg. No approved or clinically validated dose exists. | Oral precursors: NR 300-2,000 mg/day, NMN 250-900 mg/day, NAM 500-1,500 mg/day; IV NAD+ 500-1,500 mg per session. |
| Dosing Frequency | Acute, single-session (pre-workout) use rather than a daily or continuous compound. Users typically leave rest days between doses to limit tolerance buildup and cardiovascular strain; there is no evidence base for any regular dosing schedule. | Oral precursors once daily (higher doses split AM/midday); IV NAD+ weekly-to-monthly at clinics. |
| Administration | — | Oral (precursors), Intravenous, Intramuscular, Subcutaneous |
| Side Effects | Reported and expected effects reflect its sympathomimetic activity: elevated blood pressure and heart rate, palpitations or tachycardia, chest tightness, shortness of breath (dyspnoea), overheating (hyperthermia), anxiety and jitteriness, headache, insomnia,… | Nicotinamide Riboside (NR) NR has the best-characterized safety profile of the NAD+ precursors. Across published RCTs at 1,000-2,000 mg/day for up to 12 weeks, adverse effects have been mild and uncommon: - Gastrointestinal upset (5-10% of users) - Mild… |
| Molecular Weight | 129.24 g/mol (free base; molecular formula C8H19N). Commonly supplied as a salt (e.g., hydrochloride or, historically, camphorsulfonate), which increases the labeled mass per dose. | 663.4 g/mol (NAD+); NR 255.3 g/mol; NMN 334.2 g/mol; NAM 122.1 g/mol |
| Common Vial Sizes | — | 100mg, 250mg, 500mg |
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DMHA: potential benefits
- Increased energy and perceived training intensity - the reason it is added to pre-workout products (reported by users; not established in any controlled trial)
- Sharper focus and heightened alertness from central nervous system stimulation
- Appetite suppression, which is why it appears in 'fat-burner' formulas
- Mild mood lift or euphoria reported anecdotally
- Users often describe a longer, 'smoother' stimulant feel than caffeine alone - again anecdotal, not clinically demonstrated
NAD+: potential benefits
- Restores age-associated NAD+ decline — 50% loss between young and older adulthood
- Increases peripheral blood NAD+ by up to 142% at 1,000 mg NR daily (Elhassan 2019)
- Supports sirtuin-mediated gene regulation and PARP-mediated DNA repair
- Improves muscle insulin sensitivity in prediabetic postmenopausal women (Yoshino 2021)
- Increases aerobic performance in amateur runners at 300-600 mg NMN (Liao 2021)
- Reduces inflammatory cytokines (IL-6, TNF-alpha) in middle-aged/elderly (Martens, Elhassan)
- Brain NAD+ elevation demonstrated in Parkinson trial (Brakedal 2022)
- Excellent safety profile at evidence-supported doses (500-2000 mg/day NR)
Frequently asked
What's the difference between DMHA and NAD+?
DMHA is a energy & performance that dmha (octodrine; 2-amino-6-methylheptane / 1,5-dimethylhexylamine) is a simple aliphatic amine that behaves as an indirect sympathomimetic - structurally and pharmacologically a…. NAD+ is a longevity that redox cofactor function nad+ serves as the primary electron acceptor in catabolic reactions (glycolysis, tca cycle, fatty acid oxidation), cycling between its oxidized (nad+) and…. The two differ in mechanism, half-life (Not formally characterized in humans. After ingestion, octodrine is rapidly metabolized to heptaminol, which becomes the predominant compound detected in blood and urine within hours [PMID:39401652]. Users commonly report perceptible stimulant effects lasting roughly 3-6 hours, but this is anecdotal rather than measured pharmacokinetics. vs Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent), and typical dose range.
Which has the longer half-life, DMHA or NAD+?
DMHA has a half-life of Not formally characterized in humans. After ingestion, octodrine is rapidly metabolized to heptaminol, which becomes the predominant compound detected in blood and urine within hours [PMID:39401652]. Users commonly report perceptible stimulant effects lasting roughly 3-6 hours, but this is anecdotal rather than measured pharmacokinetics.. NAD+ has a half-life of Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Can you stack DMHA and NAD+?
Stacking depends on mechanism overlap, safety profile, and goals. DMHA and NAD+ should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.