Cardiogen vs NAD+
Side-by-side comparison of Cardiogen and NAD+: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Cardiogen
NAD+
Cardiogen
Cardiogen is a short synthetic peptide developed in Russia by Vladimir Khavinson and his collaborators at the St. Petersburg Institute of Bioregulation and Gerontology, positioned as a "myocardial bioregulator" intended…
No vendor price on file.
Full Cardiogen profileNAD+
NAD+ (nicotinamide adenine dinucleotide, oxidized form) is a pyridine dinucleotide coenzyme essential to energy metabolism, DNA repair via PARP enzymes, sirtuin-mediated gene regulation, and calcium signaling via CD38.…
Lowest listed price: $25.00 across 11 listings
Full NAD+ profileSide-by-side comparison
| Attribute | Cardiogen | NAD+ |
|---|---|---|
| Category | Recovery | Longevity |
| Research Stage | Preclinical | Phase II |
| Mechanism of Action | Mechanism of Action Cardiogen's proposed mechanism is the Khavinson short-peptide bioregulator framework applied to cardiac tissue. The three-stage model - absorption and distribution, nuclear import, sequence-selective chromatin modulation - has been detailed… | Redox Cofactor Function NAD+ serves as the primary electron acceptor in catabolic reactions (glycolysis, TCA cycle, fatty acid oxidation), cycling between its oxidized (NAD+) and reduced (NADH) forms. This fundamental energy metabolism role means every cell… |
| Half-Life | Not characterized in humans. As a short linear tetrapeptide (Ala-Glu-Asp-Arg), Cardiogen is expected to undergo rapid enzymatic hydrolysis to its constituent amino acids; no validated modern pharmacokinetic half-life has been published. | Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent |
| Typical Dose Range | 20 mg oral once daily x10 days, or 2-5 mg SC daily x10 days; 60-90 day washout | Oral precursors: NR 300-2,000 mg/day, NMN 250-900 mg/day, NAM 500-1,500 mg/day; IV NAD+ 500-1,500 mg per session. |
| Dosing Frequency | — | Oral precursors once daily (higher doses split AM/midday); IV NAD+ weekly-to-monthly at clinics. |
| Administration | — | Oral (precursors), Intravenous, Intramuscular, Subcutaneous |
| Side Effects | Side Effects and Safety Cardiogen has been used in Russian clinical settings and post-Soviet supplement channels for roughly 20 years without a substantial adverse-event literature. That absence is reassuring in direction but must be contextualised against the… | Nicotinamide Riboside (NR) NR has the best-characterized safety profile of the NAD+ precursors. Across published RCTs at 1,000-2,000 mg/day for up to 12 weeks, adverse effects have been mild and uncommon: - Gastrointestinal upset (5-10% of users) - Mild… |
| Molecular Weight | 489.5 g/mol (C18H31N7O9, tetrapeptide Ala-Glu-Asp-Arg) | 663.4 g/mol (NAD+); NR 255.3 g/mol; NMN 334.2 g/mol; NAM 122.1 g/mol |
| Common Vial Sizes | — | 100mg, 250mg, 500mg |
Price History
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Cardiogen: potential benefits
- Cardiovascular tissue support
- Cardiac muscle repair
- Improved heart function markers
- Anti-aging effects on heart tissue
NAD+: potential benefits
- Restores age-associated NAD+ decline — 50% loss between young and older adulthood
- Increases peripheral blood NAD+ by up to 142% at 1,000 mg NR daily (Elhassan 2019)
- Supports sirtuin-mediated gene regulation and PARP-mediated DNA repair
- Improves muscle insulin sensitivity in prediabetic postmenopausal women (Yoshino 2021)
- Increases aerobic performance in amateur runners at 300-600 mg NMN (Liao 2021)
- Reduces inflammatory cytokines (IL-6, TNF-alpha) in middle-aged/elderly (Martens, Elhassan)
- Brain NAD+ elevation demonstrated in Parkinson trial (Brakedal 2022)
- Excellent safety profile at evidence-supported doses (500-2000 mg/day NR)
Frequently asked
What's the difference between Cardiogen and NAD+?
Cardiogen is a recovery that mechanism of action cardiogen's proposed mechanism is the khavinson short-peptide bioregulator framework applied to cardiac tissue. the three-stage model - absorption and…. NAD+ is a longevity that redox cofactor function nad+ serves as the primary electron acceptor in catabolic reactions (glycolysis, tca cycle, fatty acid oxidation), cycling between its oxidized (nad+) and…. The two differ in mechanism, half-life (Not characterized in humans. As a short linear tetrapeptide (Ala-Glu-Asp-Arg), Cardiogen is expected to undergo rapid enzymatic hydrolysis to its constituent amino acids; no validated modern pharmacokinetic half-life has been published. vs Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent), and typical dose range.
Which has the longer half-life, Cardiogen or NAD+?
Cardiogen has a half-life of Not characterized in humans. As a short linear tetrapeptide (Ala-Glu-Asp-Arg), Cardiogen is expected to undergo rapid enzymatic hydrolysis to its constituent amino acids; no validated modern pharmacokinetic half-life has been published.. NAD+ has a half-life of Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Can you stack Cardiogen and NAD+?
Stacking depends on mechanism overlap, safety profile, and goals. Cardiogen and NAD+ should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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