Alpha-Lipoic Acid vs MOTS-c
Side-by-side comparison of Alpha-Lipoic Acid and MOTS-c: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Alpha-Lipoic Acid
MOTS-c
Alpha-Lipoic Acid
Alpha-lipoic acid (ALA), also known as thioctic acid or 1,2-dithiolane-3-pentanoic acid, is a sulfur-containing eight-carbon fatty acid derivative synthesized endogenously in mitochondria by lipoic acid synthase (LIAS).…
No vendor price on file.
Full Alpha-Lipoic Acid profileMOTS-c
MOTS-c (Mitochondrial ORF of the Twelve S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide — a member of a recently discovered class of small peptides encoded in mitochondrial DNA rather than nuclear DNA. It…
Lowest listed price: $44.99 across 9 listings
Full MOTS-c profileSide-by-side comparison
| Attribute | Alpha-Lipoic Acid | MOTS-c |
|---|---|---|
| Category | Foundational | Longevity & Cellular Health |
| Research Stage | Preclinical | Preclinical |
| Mechanism of Action | Alpha-lipoic acid has two distinct biological identities. The endogenous pool — synthesized by mitochondrial lipoic acid synthase (LIAS) and covalently attached to specific lysine residues on dehydrogenase complex subunits — is catalytically essential and not… | A New Class of Signaling Molecule MOTS-c belongs to the mitochondrial-derived peptides (MDPs) - a class of small peptides encoded within mitochondrial DNA open reading frames that were historically thought to encode only ribosomal RNAs. The known MDPs include:… |
| Half-Life | — | ~4–6 hours |
| Typical Dose Range | — | 5,000–10,000 mcg (5–10 mg) per injection |
| Dosing Frequency | — | 2-3 times per week |
| Administration | — | Subcutaneous, Intramuscular |
| Side Effects | Alpha-lipoic acid is generally well-tolerated at standard doses (300-600 mg/day), but the side-effect profile is not completely benign and deserves attention particularly for long-term high-dose use and for users with specific comorbidities. GASTROINTESTINAL.… | Reported Effects (limited human data) - Injection site reactions — Mild erythema, transient itching at SC injection site. Site rotation minimizes. Probably the single most reported issue. - Transient fatigue — Some users report mild fatigue in the first week… |
| Molecular Weight | — | 2174 Da |
| Common Vial Sizes | — | 5mg, 10mg |
Price History
5 data points- OF
- BM
- Half Nattys
- Ion Peptide
- Disguised Alpha
- BHG Labs
Alpha-Lipoic Acid: potential benefits
- No structured benefit list published.
MOTS-c: potential benefits
- Insulin sensitivity
- Exercise mimicry
- Metabolic health
- Anti-aging
- Fat oxidation
- Longevity
Frequently asked
What's the difference between Alpha-Lipoic Acid and MOTS-c?
Alpha-Lipoic Acid is a foundational that alpha-lipoic acid has two distinct biological identities. the endogenous pool — synthesized by mitochondrial lipoic acid synthase (lias) and covalently attached to specific lysine…. MOTS-c is a longevity & cellular health that a new class of signaling molecule mots-c belongs to the mitochondrial-derived peptides (mdps) - a class of small peptides encoded within mitochondrial dna open reading frames that…. The two differ in mechanism, half-life (not reported vs ~4–6 hours), and typical dose range.
Which has the longer half-life, Alpha-Lipoic Acid or MOTS-c?
Alpha-Lipoic Acid has a half-life of not reported. MOTS-c has a half-life of ~4–6 hours. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Can you stack Alpha-Lipoic Acid and MOTS-c?
Stacking depends on mechanism overlap, safety profile, and goals. Alpha-Lipoic Acid and MOTS-c should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Before you buy Alpha-Lipoic Acid or MOTS-c
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.