Best Nootropics for Sleep Optimization — 2026

Delta sleep-inducing peptide (DSIP) is a nonapeptide — a 9-amino-acid neuropeptide with sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE, 848 Da molecular weight) — first isolated in 1977 from the cerebral venous blood of rabbits subjected to electrical stimulation of the…

Epithalon (also spelled **Epitalon**, sequence **Ala-Glu-Asp-Gly / AEDG**) is a synthetic tetrapeptide designed by Prof. Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology in the 1980s as a short-chain analog of **epithalamin**, a peptide extract …

Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro, 750 Da molecular weight) developed in the 1990s at the Institute of Molecular Genetics of the Russian Academy of Sciences as a synthetic analog of tuftsin — an immunomodulatory tetrapeptide (Thr-Lys-Pro-Arg) that i…

**Melatonin** (chemical name *N-acetyl-5-methoxytryptamine*) is an endogenous neurohormone synthesized primarily by the **pineal gland** and, in smaller quantities, by the retina, gut, skin, bone marrow, lymphocytes, and mitochondria across most tissues. It is the body's principa…

Glycine is the simplest amino acid—a single hydrogen atom replacing the typical side chain found in other proteinogenic amino acids—yet it performs an wide range of biological functions. Despite being classified as "non-essential" because humans can synthesize it endogenously fro…

**L-Theanine** is a **non-proteinogenic amino acid** found almost exclusively in **tea (Camellia sinensis)** and a handful of edible mushrooms, and it has become the single most widely-used calm-focus nootropic in the modern supplement market — both on its own at 100-400mg doses …

**L-Tryptophan** is one of the nine **essential amino acids** — meaning the human body cannot synthesize it and must obtain it from dietary protein — and is the direct metabolic precursor to **serotonin**, **melatonin**, and (via a separate route) the vitamin **niacin (nicotinami…

Magnesium is the fourth most abundant cation in the human body and the second most abundant intracellular cation after potassium, with approximately 25 grams present in a typical adult—roughly 60% stored in bone, 27% in muscle, 6-7% in other soft tissues, and less than 1% in extr…

**Magnesium L-Threonate** is a proprietary chelated form of magnesium in which the magnesium cation is bound to **L-threonic acid** — a metabolite of ascorbic acid (vitamin C) — forming the salt commonly marketed under the brand name **Magtein**. It was developed in the mid-2000s…

Apigenin is a plant-derived flavone (4',5,7-trihydroxyflavone) that occurs widely in the plant kingdom as a constituent of leaves, flowers, and seeds. Structurally it is a flavone — distinguished from flavonols like quercetin and fisetin by the absence of a 3-hydroxyl group — gi…

Ashwagandha (Withania somnifera, also called "Indian ginseng" and "winter cherry") is the most studied and most clinically validated herbal adaptogen in the contemporary supplement market. It is the botanical anchor of Ayurvedic medicine — the indigenous medical tradition of the …

Pinealon is a **synthetic tripeptide — glutamyl-aspartyl-arginine (Glu-Asp-Arg, or EDR)** — developed by the St Petersburg Institute of Bioregulation and Gerontology (IBG) under the leadership of **Professor Vladimir Khavinson**, the dominant figure in what is collectively known …

**Inositol** is a naturally-occurring **cyclic sugar alcohol (cyclohexanehexol)** that functions as a critical structural component of cell membranes and a **second-messenger precursor** in intracellular signaling. Of the nine possible stereoisomers of inositol, only two — **myo-…

Proprietary nasal spray blend designed to support deep sleep and recovery.