Anti-Anxiety
Calm composure without sedation
Overview
Three compounds with strong evidence for anxiolysis that work through different, complementary mechanisms — GABAergic, adaptogenic, and glutamatergic.
The Protocol — 3 Compounds
Each compound is scored for evidence, synergy, and cycling compatibility. Start at the low end of any range and titrate up.
1L-Theanine
GABA modulation and alpha wave promotion for calm alertness
2Ashwagandha (KSM-66)
Reduces cortisol by 30% in clinical trials, adaptogenic
3Magnesium L-Threonate
Crosses BBB to modulate NMDA receptors, reduces neuronal excitability
Onset
L-Theanine: 30 min. Ashwagandha: 2–4 weeks. Magnesium: 1 week
Cycling
Cycle Ashwagandha: 8 weeks on / 2 weeks off
Monthly
$28
Level
beginner
Expected Effects
Noticeable reduction in baseline anxiety within 2 weeks. Better stress resilience and sleep quality.
Who It's For
Anyone dealing with chronic stress, social anxiety, or stress-related sleep issues.
What to Track
Anxiety rating (1-10), sleep quality, stress resilience
Cautions
Ashwagandha may affect thyroid function — monitor if you have thyroid conditions. Can cause drowsiness in some people.
Pre-formulated options
This stack's compounds overlap with formulas from our trusted partner. If you'd rather not source individual ingredients, these capsule products cover a chunk of the protocol in one product.
Affiliate disclosure: BodyHackGuide earns a small commission if you buy through these links at no extra cost to you. Vetted for quality, not paid for placement.
Check compound interactions
Before starting any stack, verify there are no contraindications with medications or other supplements you take.
Frequently Asked Questions
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