Sobetirome (GC-1) Dosage Guide: Protocols, Calculator & Safety
Everything you need to know about Sobetirome (GC-1) dosing: protocols, safety, and where to buy.
Half-Life
Not established in humans; no peer-reviewed human pharmacokinetic study has been published, and the phase 1 program results were not reported in the peer-reviewed literature (PMID: 19002578)
Administration Routes
Dosage Calculator
Calculate exact dosing for Sobetirome (GC-1).
Dosing data for Sobetirome (GC-1) is being researched. Check the compound page for the latest information.
Side Effects & Safety
Contraindications
Mechanism-based, since no human trial has defined contraindications. Thyroid hormone receptor agonism is inappropriate for anyone with existing hyperthyroidism, atrial fibrillation or unstable coronary disease, and it suppresses thyroid stimulating hormone and disturbs thyroid function testing (PMID: 10965874). The rat liver and pancreas proliferation findings argue against use by anyone with liver disease or pancreatic disease (PMID: 16574785). No human pregnancy, lactation or pediatric data exist. Anyone taking levothyroxine or antithyroid medication would have their treatment monitoring confounded.
Frequently Asked Questions
What is the recommended Sobetirome (GC-1) dosage?
Dosage for Sobetirome (GC-1) varies by protocol. Consult a qualified healthcare provider.
How often should I take Sobetirome (GC-1)?
Administration frequency depends on the specific protocol. Consult current research literature.
Does Sobetirome (GC-1) need to be cycled?
Cycling requirements depend on the protocol. Follow established research guidelines.
What are Sobetirome (GC-1) side effects?
No peer-reviewed human safety data. The animal record contains a specific warning: GC-1 acted as a strong mitogen in rats, inducing hepatocyte proliferation in the absence of tissue injury and massive pancreatic acinar cell proliferation (PMID: 16574785). Thyroid receptor beta agonism as a class suppresses thyroid stimulating hormone, which was demonstrated in the rat dose-response work (PMID: 10965874). The cardiac sparing seen in rats and monkeys is relative, not absolute; tachycardia appeared at higher exposure in rats (PMID: 14701670).
Where can I buy Sobetirome (GC-1)?
Compare 1 listings from 1 vendor on our price comparison page, starting from $149.99.
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