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    NADH Dosage Guide: Protocols, Calculator & Safety

    Everything you need to know about NADH dosing: protocols, safety, and where to buy.

    Half-Life

    No published human value. No human pharmacokinetic study of oral NADH was found, and in mice swallowed NADH did not raise urinary nicotinamide metabolites the way injected NADH did (PMID: 16802695).

    Administration Routes

    OralSublingualIntravenousIntramuscular

    Dosage Calculator

    Calculate exact dosing for NADH.

    Dosing data for NADH is being researched. Check the compound page for the latest information.

    Side Effects & Safety

    ## What the trials recorded In a 26-patient chronic fatigue syndrome crossover trial, no severe adverse effects related to NADH were observed (PMID: 10071523). In a 35-person jet lag trial of sublingual NADH, no adverse effects were observed (PMID: 12385067). In an open-label study of 17 people with Alzheimer-type dementia followed for 8 to 12 weeks, no side effects were reported (PMID: 8834355). For NADH combined with coenzyme Q10, an 8-week trial in 80 patients described the combination as generally safe and well tolerated (PMID: 26212172). In the 207-patient trial, 8 people in the active group left the study because of adverse effects (5 with upper abdominal pain and 3 with dizziness) against 11 in the placebo group, and no serious adverse events were reported (PMID: 34444817). A 2023 systematic review of 10 randomized trials with 489 participants, covering NADH and NAD precursors together, listed muscle pain, nervous system complaints, fatigue, sleep disturbance and headache among reported side effects and judged none a serious risk (PMID: 37971292). A 2025 systematic review of dietary supplements in ME/CFS, which included NADH trials, noted that six studies reported adverse effects such as nausea and insomnia across the supplements reviewed (PMID: 39940333). ## Animal toxicology In a 26-week study from the Birkmayer group in Vienna, which makes a stabilized NADH product, 80 rats were split between daily NADH tablets and placebo (PMID: 12635493). NADH caused no deaths or treatment-related clinical signs and no differences in blood tests or organ weights, and tissue findings were similar to controls; treated females gained more weight and ate up to 10 percent more food (PMID: 12635493). ## Gaps in the safety record The controlled NADH trials summarized here lasted from one day to 6 months, apart from one 24-month comparison without placebo (PMID: 15377055). No human safety data in pregnancy or breastfeeding were found; the 207-patient trial excluded pregnant and breastfeeding women (PMID: 34444817).

    Contraindications

    **Levodopa.** In a 15-patient open study, intravenous NADH raised plasma levodopa levels on the first day of infusion in people with Parkinson's disease taking levodopa (PMID: 9013405). That is a mechanism-based reason for caution when the two are combined. **Pregnancy and breastfeeding.** No human safety data were found, and the largest NADH trial excluded pregnant and breastfeeding women (PMID: 34444817).

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    Frequently Asked Questions

    What is the recommended NADH dosage?

    Dosage for NADH varies by protocol. Consult a qualified healthcare provider.

    How often should I take NADH?

    Administration frequency depends on the specific protocol. Consult current research literature.

    Does NADH need to be cycled?

    Cycling requirements depend on the protocol. Follow established research guidelines.

    What are NADH side effects?

    ## What the trials recorded In a 26-patient chronic fatigue syndrome crossover trial, no severe adverse effects related to NADH were observed (PMID: 10071523). In a 35-person jet lag trial of sublingual NADH, no adverse effects were observed (PMID: 12385067). In an open-label study of 17 people with Alzheimer-type dementia followed for 8 to 12 weeks, no side effects were reported (PMID: 8834355). For NADH combined with coenzyme Q10, an 8-week trial in 80 patients described the combination as generally safe and well tolerated (PMID: 26212172). In the 207-patient trial, 8 people in the active group left the study because of adverse effects (5 with upper abdominal pain and 3 with dizziness) against 11 in the placebo group, and no serious adverse events were reported (PMID: 34444817). A 2023 systematic review of 10 randomized trials with 489 participants, covering NADH and NAD precursors together, listed muscle pain, nervous system complaints, fatigue, sleep disturbance and headache among reported side effects and judged none a serious risk (PMID: 37971292). A 2025 systematic review of dietary supplements in ME/CFS, which included NADH trials, noted that six studies reported adverse effects such as nausea and insomnia across the supplements reviewed (PMID: 39940333). ## Animal toxicology In a 26-week study from the Birkmayer group in Vienna, which makes a stabilized NADH product, 80 rats were split between daily NADH tablets and placebo (PMID: 12635493). NADH caused no deaths or treatment-related clinical signs and no differences in blood tests or organ weights, and tissue findings were similar to controls; treated females gained more weight and ate up to 10 percent more food (PMID: 12635493). ## Gaps in the safety record The controlled NADH trials summarized here lasted from one day to 6 months, apart from one 24-month comparison without placebo (PMID: 15377055). No human safety data in pregnancy or breastfeeding were found; the 207-patient trial excluded pregnant and breastfeeding women (PMID: 34444817).

    Where can I buy NADH?

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