Levo-tetrahydropalmatine (l-THP) Dosage Guide: Protocols, Calculator & Safety
Everything you need to know about Levo-tetrahydropalmatine (l-THP) dosing: protocols, safety, and where to buy.
Half-Life
Not established in the sources retrieved; a randomized, double-blind, placebo-controlled human study collected full plasma pharmacokinetic profiles in 19 cocaine users receiving l-THP 30 mg twice daily for 4 days but did not report a terminal half-life (PMID: 27363313)
Administration Routes
Dosage Calculator
Calculate exact dosing for Levo-tetrahydropalmatine (l-THP).
Dosing data for Levo-tetrahydropalmatine (l-THP) is being researched. Check the compound page for the latest information.
Side Effects & Safety
Contraindications
Sourced: liver disease or concurrent hepatotoxic exposure, given documented hepatitis after prolonged use of l-THP-containing herbal products (PMID: 7944049, PMID: 9537855), and children, given reported coma and cardiovascular collapse after single ingestions in three young children (PMID: 8774209). Mechanism-based: tetrahydropalmatine is a mechanism-based CYP2D6 inhibitor in human liver microsomes, so drugs cleared by CYP2D6 are an interaction concern (PMID: 41876357), and dopamine receptor antagonism is a mechanism-based concern for anyone taking dopaminergic or antipsychotic medication (PMID: 17361394).
Frequently Asked Questions
What is the recommended Levo-tetrahydropalmatine (l-THP) dosage?
Dosage for Levo-tetrahydropalmatine (l-THP) varies by protocol. Consult a qualified healthcare provider.
How often should I take Levo-tetrahydropalmatine (l-THP)?
Administration frequency depends on the specific protocol. Consult current research literature.
Does Levo-tetrahydropalmatine (l-THP) need to be cycled?
Cycling requirements depend on the protocol. Follow established research guidelines.
What are Levo-tetrahydropalmatine (l-THP) side effects?
The strongest human safety signal comes from herbal products containing l-THP. Jin Bu Huan Anodyne tablets caused acute hepatitis in seven previously healthy adults after a mean of 20 weeks of use, resolving after stopping and recurring on rechallenge in two people (PMID: 7944049), and chronic hepatitis with moderate fibrosis in a further case (PMID: 9537855). A case series described life-threatening neurological and cardiovascular effects including coma in three children after a single acute ingestion, with hepatitis in three adults on long-term use (PMID: 8774209). In the controlled cocaine-user study, side effect counts did not differ from placebo and heart rate, blood pressure, blood counts and electrocardiograms were unchanged (PMID: 27363313). Sedative and hypnotic effects are described for the compound in its long clinical use in China (PMID: 27606501).
Where can I buy Levo-tetrahydropalmatine (l-THP)?
Compare 1 listings from 1 vendor on our price comparison page, starting from $59.99.
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