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    NootropicsPhase 2

    J147 Dosage Guide: Protocols, Calculator & Safety

    Everything you need to know about J147 dosing: protocols, safety, and where to buy.

    Half-Life

    Not established in humans; the phase 1 study measured terminal half-life but has not reported results (NCT03838185). After oral dosing in mice, half-life was about 1.5 hours in plasma and 2.5 hours in brain, with oral bioavailability calculated at 28 percent and a brain to blood ratio of about 0.5 (PMID: 23673233).

    Administration Routes

    OralIntravenous infusion

    Dosage Calculator

    Calculate exact dosing for J147.

    Dosing data for J147 is being researched. Check the compound page for the latest information.

    Side Effects & Safety

    No human safety results have been published. The phase 1 single ascending dose study in 64 healthy young and elderly volunteers listed adverse events, electrocardiograms, serum chemistry, hematology, urinalysis and physical and neurological examination as primary endpoints and completed in February 2020, but no results have been posted (NCT03838185). In animals, single doses of 2 g/kg in rats and mice produced no acute toxicity, and the Ames test, hERG assay and CYP3A4 assays were negative; prenatal exposure in mice produced normal offspring (PMID: 23673233). Because phenyl hydrazides can in principle yield carcinogenic aromatic amines or hydrazines, this was tested directly and J147 was not metabolized to those products in human or mouse microsomes or mouse plasma (PMID: 23582448). In a rat hepatoma cell line, adverse effects on cellular activity, mainly mitochondrial function, appeared only at high concentrations, with the sustained toxic concentration estimated at about 90 micromolar (PMID: 25364619).

    Contraindications

    None established in humans. The published phase 1 protocol excluded volunteers with clinically significant cardiovascular, neurological, psychiatric, hepatic or renal disease, required them to avoid grapefruit and Seville oranges, and excluded anyone who had taken known hepatic or renal clearance altering agents in the preceding 30 days, which indicates sponsor concern about metabolic interactions (NCT03838185). Mechanism-based caution: the target is the mitochondrial alpha-F1-ATP synthase and the compound works by modest inhibition of that enzyme (PMID: 29316249), so it is a metabolic intervention rather than a neutral supplement, and cell work shows mitochondrial effects at high concentrations (PMID: 25364619). No pregnancy, lactation or drug interaction data exist in humans.

    Check interactions with the Interaction Checker →

    Frequently Asked Questions

    What is the recommended J147 dosage?

    Dosage for J147 varies by protocol. Consult a qualified healthcare provider.

    How often should I take J147?

    Administration frequency depends on the specific protocol. Consult current research literature.

    Does J147 need to be cycled?

    Cycling requirements depend on the protocol. Follow established research guidelines.

    What are J147 side effects?

    No human safety results have been published. The phase 1 single ascending dose study in 64 healthy young and elderly volunteers listed adverse events, electrocardiograms, serum chemistry, hematology, urinalysis and physical and neurological examination as primary endpoints and completed in February 2020, but no results have been posted (NCT03838185). In animals, single doses of 2 g/kg in rats and mice produced no acute toxicity, and the Ames test, hERG assay and CYP3A4 assays were negative; prenatal exposure in mice produced normal offspring (PMID: 23673233). Because phenyl hydrazides can in principle yield carcinogenic aromatic amines or hydrazines, this was tested directly and J147 was not metabolized to those products in human or mouse microsomes or mouse plasma (PMID: 23582448). In a rat hepatoma cell line, adverse effects on cellular activity, mainly mitochondrial function, appeared only at high concentrations, with the sustained toxic concentration estimated at about 90 micromolar (PMID: 25364619).

    Where can I buy J147?

    Compare 1 listings from 1 vendor on our price comparison page, starting from $99.99.

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