Melanotan-1
Tanning PeptideFDA-approved for EPP (Scenesse, 2019)Also known as: MT-1, Afamelanotide, Scenesse
Melanotan-1 (afamelanotide, brand name Scenesse) is a synthetic analog of alpha-melanocyte stimulating hormone (alpha-MSH). It is FDA-approved (2019) under the trade name Scenesse for prevention of phototoxicity in adult patients with erythropoietic protoporphyria (EPP) - a rare metabolic disorder where sunlight exposure causes severe pain. Unlike Melanotan-2, MT-1 is selective for the MC1R (melanocortin-1 receptor) and does not significantly activate MC3R/MC4R, meaning it produces tanning without the libido and appetite-suppression effects of MT-2.
Overview
At A Glance
Binds the melanocortin-1 receptor (MC1R) on melanocytes, activating Gs-coupled signaling, raising intracellular cAMP, and upregulating tyrosinase activity. Tyrosinase converts tyrosine to melanin precursors, leading to increased melanogenesis and skin darkening. The MC1R selectiv…
Overview
Melanotan-1 (afamelanotide, brand name Scenesse) is a synthetic analog of alpha-melanocyte stimulating hormone (alpha-MSH). It is FDA-approved (2019) under the trade name Scenesse for prevention of phototoxicity in adult patients with erythropoietic protoporphyria (EPP) - a rare metabolic disorder where sunlight exposure causes severe pain. Unlike Melanotan-2, MT-1 is selective for the MC1R (melanocortin-1 receptor) and does not significantly activate MC3R/MC4R, meaning it produces tanning without the libido and appetite-suppression effects of MT-2. The selectivity also means lower nausea risk during loading.
Potential Research Fields
Chemical Information
IUPAC Name
Not yet available
CAS Number
Not yet available
Molecular Formula
~1646 Da (Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2)
Molecular Mass
Not yet available
Dosing & Protocols
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Research
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Interactions
Contraindications
Personal history of melanoma or dysplastic naevi syndrome. Pregnancy and breastfeeding. Active liver disease. Pediatric use is contraindicated outside specialist EPP protocols.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
No listings found for Melanotan-1.
Research Score
4 PubMed studies
Quality Indicators
Data Completeness
75%Research Credibility
Limited research available
Quick Facts
Half-Life
~30 minutes serum (subcutaneous absorption is the rate-limiter for clinical use)
Administration
Subcutaneous, Implant (Scenesse uses bioresorbable implant)
Trial Phase
FDA-approved for EPP (Scenesse, 2019)
Safety Profile
Common Side Effects
- • Transient flushing
- • Mild nausea
- • Headache
- • Fatigue during loading phase
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is Melanotan-1 used for in research?
Melanotan-1 (afamelanotide, brand name Scenesse) is a synthetic analog of alpha-melanocyte stimulating hormone (alpha-MSH). It is FDA-approved (2019) under the trade name Scenesse for prevention of phototoxicity in adult patients with erythropoietic protoporphyria (EPP) - a rare metabolic disorder where sunlight exposure causes severe pain.
Unlike Melanotan-2, MT-1 is selective for the MC1R (melanocortin-1 receptor) and does not significantly activate MC3R/MC4R, meaning it produces tanning without the libido and appetite-suppression effects of MT-2. The selectivity also means lower nausea risk during loading.
What forms does Melanotan-1 come in?
Melanotan-1 is available in vials, capsules, and sprays forms.
How much does Melanotan-1 cost?
Pricing varies by vendor and form.
How do I compare Melanotan-1 vendors?
Compare prices, payment methods, shipping, and COA scores across 0 vendors.
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