Also known as: PNC-27 peptide, p53-HDM2 inhibitor peptide, anti-cancer peptide
PNC-27 is a p53-derived peptide that selectively induces membranolysis in cancer cells. It contains the p53 transactivation domain (amino acids 17–26) linked to a membrane-penetrating transmembrane domain (HDM2 binding domain).
Price check
Out of stock right now
None of the vendors we track has it in stock.
Overview
At A Glance
PNC-27 is a 32-amino-acid chimeric peptide that fuses the HDM-2 (MDM2)-binding domain of p53 - residues 12-26 (PPLSQETFSDLWKLL) - to a C-terminal membrane-residency / penetratin-derived leader sequence. Cancer cells aberrantly express HDM-2 protein on their plasma-membrane surfac…
Overview
PNC-27 is a p53-derived peptide that selectively induces membranolysis in cancer cells. It contains the p53 transactivation domain (amino acids 17–26) linked to a membrane-penetrating transmembrane domain (HDM2 binding domain). Uniquely, PNC-27 kills cancer cells by binding to HDM2 protein on the cancer cell membrane surface — where HDM2 (the p53 negative regulator) is aberrantly expressed — creating pores in the cancer cell plasma membrane. Normal cells, which do not express surface HDM2, are spared. This selectivity distinguishes PNC-27 from most cytotoxic compounds. Published research comes primarily from Sarafraz-Yazdi et al. and has demonstrated selective pancreatic cancer, leukemia, and breast cancer cell kill in vitro. PNC-27 remains preclinical with no clinical trials completed.
Chemical Information
IUPAC Name
Not yet available
CAS Number
Not yet available
Molecular Formula
Not yet available
Molecular Mass
4031.8 g/mol
Amino Acid Sequence
Dosing & Protocols
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Research
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Interactions
Interaction and contraindication data is being compiled for PNC-27. Check back soon.
General Safety Note
Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented.
$119.00
$11.9000
1
1
vial
| Vendor | Product | Form | Qty | Price | $/mg | Coupon | |
|---|---|---|---|---|---|---|---|
 |
PNC-27 10mg | vial | 1 vial● Out of Stock | $119.00BEST | $11.90 | — |
Tracking since Apr 22, 2026 · 1 data point
Vendors Selling PNC-27
How we score these vendors
Every supplier above is graded 0 to 100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank.
Related Compounds
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B7-33
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Diisopropylamine dichloroacetate (DADA)
OtherApproved (Japan)DADA is the abbreviation the research chemical market uses for diisopropylamine dichloroacetate, the diisopropylamine salt of dichloroacetic acid, CAS 660-27-5.
Indole-3-propionamide (IPAM)
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Kisspeptin-10 (KSPTN)
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Melanotan I
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View Full Dosage Guide →
Protocols, calculator & safety for PNC-27
Research Score
0 PubMed results
Quality Indicators
Data Completeness
63%Quick Facts
Half-Life
Unknown (no published PK data)
Molecular Weight
4031.8 g/mol
Administration
Subcutaneous, Intravenous, Intraperitoneal
Trial Phase
Preclinical
Safety Profile
Common Side Effects
- • No human safety data exists
- • In vitro toxicity against cancer cells only
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is PNC-27 used for in research?
PNC-27 is a p53-derived peptide that selectively induces membranolysis in cancer cells. It contains the p53 transactivation domain (amino acids 17–26) linked to a membrane-penetrating transmembrane domain (HDM2 binding domain). Uniquely, PNC-27 kills cancer cells by binding to HDM2 protein on the cancer cell membrane surface — where HDM2 (the p53 negative regulator) is aberrantly expressed — creating pores in the cancer cell plasma membrane. Normal cells, which do not express surface HDM2, are spared. This selectivity distinguishes PNC-27 from most cytotoxic compounds. Published research comes primarily from Sarafraz-Yazdi et al. and has demonstrated selective pancreatic cancer, leukemia, and breast cancer cell kill in vitro. PNC-27 remains preclinical with no clinical trials completed.
What forms does PNC-27 come in?
PNC-27 is available in vial form.
How do I compare PNC-27 vendors?
Compare prices, payment methods, shipping, and COA scores across 1 vendor.
How many vendors sell PNC-27, and what does it cost per mg?
1 of the vendors BodyHackGuide tracks list PNC-27 (1 listing). The lowest listed price BodyHackGuide has recorded for PNC-27 is $119.00. No PNC-27 listing recorded as in stock carries a milligram count, so BodyHackGuide states no price per milligram for PNC-27.
Which vendors have third-party COAs for PNC-27 on file at BodyHackGuide?
BodyHackGuide holds 5 third-party certificate records for PNC-27, from . No editor has read any of BodyHackGuide's 5 certificate records for PNC-27. The laboratory named on BodyHackGuide's PNC-27 certificate records is Freedom Diagnostics Testing, and the newest test date on them is 6 July 2026. Each vendor page on BodyHackGuide shows how many certificate records BodyHackGuide holds for that vendor and links to each record that has its own page.
Research Tools
Related Compounds
View AllAminotadalafil
OtherPreclinicalAminotadalafil is an unapproved research analog of tadalafil, the PDE5 inhibitor marketed under the brand name Cialis for erectile dysfunction and under Adcirca for pulmonary arterial hypertension.
B7-33
OtherPreclinicalB7-33 is a single-chain, 26-amino-acid peptide engineered as a functionally selective agonist of the relaxin family peptide receptor 1 (RXFP1), designed to recapitulate the therapeutic activity of human H2 relaxin — the endogenous peptide hormone that is naturally elevated during pregnancy and has broad cardioprotective, vasodilatory, and anti-fibrotic effects.
Diisopropylamine dichloroacetate (DADA)
OtherApproved (Japan)DADA is the abbreviation the research chemical market uses for diisopropylamine dichloroacetate, the diisopropylamine salt of dichloroacetic acid, CAS 660-27-5.
Indole-3-propionamide (IPAM)
OtherPreclinicalIPAM is the market abbreviation for indole-3-propionamide, the amide of indole-3-propionic acid and a close structural relative of melatonin.
Kisspeptin-10 (KSPTN)
OtherClinical (investigational)KSPTN is the vendor shorthand for kisspeptin, a naturally occurring peptide encoded by the KISS1 gene and the master upstream regulator of the reproductive (hypothalamic-pituitary-gonadal) hormone axis.
Melanotan I
OtherFDA ApprovedMelanotan I (afamelanotide) is a linear synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) with the substitution of norleucine at position 4 and D-phenylalanine at position 7.
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