Urolithin A vs NAC
Side-by-side comparison of Urolithin A and NAC: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Urolithin A
NAC
Urolithin A
Urolithin A (3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-one; trade name Mitopure from Timeline Nutrition, formerly Amazentis) is a gut-microbiome-derived metabolite of dietary ellagitannins — polyphenolic compounds found in…
No vendor price on file.
Full Urolithin A profileNAC
N-acetylcysteine (NAC) is the acetylated form of the amino acid L-cysteine — a small thiol-containing molecule that serves as a rate-limiting precursor for glutathione (GSH) synthesis and, independently, as a direct…
Lowest listed price: $49.99 across 1 listing
Full NAC profileSide-by-side comparison
| Attribute | Urolithin A | NAC |
|---|---|---|
| Category | Mitochondrial Support | Antioxidants |
| Research Stage | Dietary Supplement (Food Ingredient) | Preclinical |
| Mechanism of Action | Urolithin A's mechanism of action centers on induction of mitophagy — the selective autophagic degradation of damaged mitochondria — with additional secondary effects on mitochondrial biogenesis, cellular stress resistance, and inflammatory signaling.… | NAC's mechanism of action operates through at least four distinct but overlapping pathways, and understanding which pathway dominates in a given clinical context is essential for predicting whether supplementation will actually help. The four pathways are (1)… |
| Half-Life | — | — |
| Typical Dose Range | — | — |
| Dosing Frequency | — | — |
| Administration | — | — |
| Side Effects | Urolithin A has an exceptionally favorable safety profile among longevity-relevant interventions, reflecting both its status as a naturally occurring gut-microbiome metabolite found in human bloodstream from ellagitannin-containing foods and deliberate… | NAC has one of the most favorable safety profiles in medicine when dosed appropriately and used for appropriate indications. Side effects are almost entirely gastrointestinal at oral therapeutic doses and anaphylactoid at high IV infusion rates; true allergic… |
| Molecular Weight | — | — |
| Common Vial Sizes | — | — |
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Frequently asked
What's the difference between Urolithin A and NAC?
Urolithin A is a mitochondrial support that urolithin a's mechanism of action centers on induction of mitophagy — the selective autophagic degradation of damaged mitochondria — with additional secondary effects on…. NAC is a antioxidants that nac's mechanism of action operates through at least four distinct but overlapping pathways, and understanding which pathway dominates in a given clinical context is essential for…. The two differ in mechanism, half-life (not reported vs not reported), and typical dose range.
Which has the longer half-life, Urolithin A or NAC?
Urolithin A has a half-life of not reported. NAC has a half-life of not reported. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Can you stack Urolithin A and NAC?
Stacking depends on mechanism overlap, safety profile, and goals. Urolithin A and NAC should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.