Thymalin vs Pinealon
Side-by-side comparison of Thymalin and Pinealon: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Thymalin
Pinealon
Thymalin
Thymalin is a thymus-derived peptide complex developed in the 1970s by Vladimir Khavinson and the Leningrad (now St. Petersburg) Institute of Bioregulation and Gerontology as part of a broader program to identify…
Lowest listed price: $44.99 across 2 listings
Full Thymalin profilePinealon
Pinealon is a synthetic tripeptide — glutamyl-aspartyl-arginine (Glu-Asp-Arg, or EDR) — developed by the St Petersburg Institute of Bioregulation and Gerontology (IBG) under the leadership of Professor Vladimir…
Lowest listed price: $45.00 across 3 listings
Full Pinealon profileSide-by-side comparison
| Attribute | Thymalin | Pinealon |
|---|---|---|
| Category | Peptides | Nootropics |
| Research Stage | Clinical (Russia-registered; not FDA-approved) | Preclinical |
| Mechanism of Action | Thymalin's mechanism of action is less precisely defined than that of single-molecule peptides, because the active principle is a mixture of peptides acting through multiple parallel pathways rather than a single well-characterized molecular interaction. The… | The proposed mechanism of Pinealon is rooted in the Khavinson school's broader theory of short-peptide tissue-specific bioregulation. The full theory is worth understanding because it underlies all twelve Russian bioregulator compounds in this catalog. The… |
| Half-Life | Short for the individual peptides in the mixture (on the order of minutes to a few hours). Biological effects persist for weeks to months after a 10-day course, which is why Thymalin is given in discrete courses rather than continuously. | Not formally characterized in humans. Short regulatory peptides of this class are cleared from plasma within minutes; the Khavinson framework proposes durable downstream gene-expression effects that outlast the brief dosing window, which is the stated rationale for pulsed cycling rather than continuous dosing. |
| Typical Dose Range | 5-15 mg | Subcutaneous (primary route): 2-10 mg/day, typically 3-5 mg, in pulsed 10-20 day cycles, 2-4 cycles/year. Intranasal: 150-800 mcg per nostril daily. Research use only; oral dosing is not recommended because the peptide is largely degraded by GI proteases. |
| Dosing Frequency | Once daily during a 10-day course; courses repeated 1-4 times per year (commonly biannually). | Once daily during a cycle (morning preferred); some advanced users split into AM + midday doses. Not dosed continuously year-round - cycles are pulsed. |
| Administration | — | — |
| Side Effects | Thymalin has a substantial safety record spanning four decades of Russian clinical use across hundreds of thousands of patients, with a relatively clean side-effect profile compared to many immunomodulatory agents. Common side effects (1-10% incidence in… | The side-effect profile of Pinealon, based on the available Russian clinical literature and user-reported experience, is described as mild and uncommon. Whether this reflects genuinely low toxicity or inadequate reporting in the available studies is a… |
| Molecular Weight | Not a single value - Thymalin is a thymic polypeptide EXTRACT (a mixture), not one defined molecule; its components are low-molecular-weight peptides, generally under ~10 kDa. Characterized active dipeptides: KE (Lys-Glu, ~275 Da) and EW (Glu-Trp, ~333 Da). | 418.40 g/mol (C15H26N6O8) |
| Common Vial Sizes | — | — |
Price History
2 data points- Ion Peptide
- Disguised Alpha
Price History
2 data points- Ion Peptide
- Disguised Alpha
Thymalin: potential benefits
- No structured benefit list published.
Pinealon: potential benefits
- Neuroprotection against oxidative and hypoxic stress (preclinical models)
- Antioxidant support - reduced oxidative DNA damage in aged neurons (in vitro)
- Cognitive and memory support in aging populations (small Russian clinical reports)
- Reduced neuronal apoptosis and support of dendritic-tree integrity in cell models
- Investigated for neuroprotection in Alzheimer's-model systems (preclinical)
Frequently asked
What's the difference between Thymalin and Pinealon?
Thymalin is a peptides that thymalin's mechanism of action is less precisely defined than that of single-molecule peptides, because the active principle is a mixture of peptides acting through multiple…. Pinealon is a nootropics that the proposed mechanism of pinealon is rooted in the khavinson school's broader theory of short-peptide tissue-specific bioregulation. the full theory is worth understanding because…. The two differ in mechanism, half-life (Short for the individual peptides in the mixture (on the order of minutes to a few hours). Biological effects persist for weeks to months after a 10-day course, which is why Thymalin is given in discrete courses rather than continuously. vs Not formally characterized in humans. Short regulatory peptides of this class are cleared from plasma within minutes; the Khavinson framework proposes durable downstream gene-expression effects that outlast the brief dosing window, which is the stated rationale for pulsed cycling rather than continuous dosing.), and typical dose range.
Which has the longer half-life, Thymalin or Pinealon?
Thymalin has a half-life of Short for the individual peptides in the mixture (on the order of minutes to a few hours). Biological effects persist for weeks to months after a 10-day course, which is why Thymalin is given in discrete courses rather than continuously.. Pinealon has a half-life of Not formally characterized in humans. Short regulatory peptides of this class are cleared from plasma within minutes; the Khavinson framework proposes durable downstream gene-expression effects that outlast the brief dosing window, which is the stated rationale for pulsed cycling rather than continuous dosing.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Thymalin or Pinealon?
Lowest listed price on BodyHackGuide: Thymalin from $44.99, Pinealon from $45.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack Thymalin and Pinealon?
Stacking depends on mechanism overlap, safety profile, and goals. Thymalin and Pinealon should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Listings from the vendors we track. Prices change often, so check the vendor before you buy.
Before you buy Thymalin or Pinealon
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.