Tesamorelin vs Tesofensine
Side-by-side comparison of Tesamorelin and Tesofensine: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Tesamorelin
Tesofensine
Tesamorelin
Tesamorelin is a stabilized synthetic analog of human growth hormone-releasing hormone (GHRH) — specifically the full 44-amino-acid GHRH sequence with a single N-terminal trans-3-hexenoyl fatty-acid modification. That…
Lowest listed price: $44.99 across 5 listings
Full Tesamorelin profileTesofensine
Tesofensine (NS2330) is an orally-administered small-molecule triple monoamine reuptake inhibitor — it blocks the reuptake of noradrenaline, dopamine, and serotonin, placing it in the same broad pharmacologic class as…
Lowest listed price: $79.99 across 2 listings
Full Tesofensine profileSide-by-side comparison
| Attribute | Tesamorelin | Tesofensine |
|---|---|---|
| Category | Growth Hormone / IGF-1 Axis | Weight Loss |
| Research Stage | FDA Approved | Preclinical |
| Mechanism of Action | Tesamorelin activates the same GHRH receptor (GHRHR) as endogenous GHRH and CJC-1295 / MOD-GRF 1-29, but with a distinct pharmacokinetic profile driven by its trans-3-hexenoyl N-terminal modification. 1. GHRH receptor agonism (Gs / cAMP / PKA / CREB pathway) -… | Tesofensine blocks the presynaptic reuptake of three monoamine neurotransmitters: noradrenaline (norepinephrine), dopamine, and serotonin. By inhibiting the neurotransmitter transporters (NET, DAT, and SERT respectively), tesofensine raises synaptic… |
| Half-Life | 30-50 minutes (plasma) | — |
| Typical Dose Range | 1,000–2,000 mcg (1–2 mg) daily | 0.25 mg - 1 mg daily (oral) |
| Dosing Frequency | Once daily subcutaneous injection | — |
| Administration | subcutaneous | — |
| Side Effects | Tesamorelin has a well-characterized side-effect profile from the FDA approval program, which is a significant advantage over non-approved GHRH analogs. Common (10% in Phase 3 trials) - Injection site reactions — erythema, pruritus, pain at site; most frequent… | Tesofensine's side effect profile reflects its monoamine-enhancing mechanism. Most effects are predictable extensions of NE, DA, and 5-HT elevation. The cardiovascular profile is the dominant clinical concern and the primary reason regulators have not approved… |
| Molecular Weight | 5135.9 Da | 298.24 g/mol |
| Common Vial Sizes | 2mg, 10mg | — |
Price History
3 data points- BM
- Half Nattys
- BHG Labs
Price tracking
Tesamorelin: potential benefits
- Reduction of visceral adipose tissue (~15% at 26 weeks in the pivotal HIV trial; FDA-label indication)
- Reduction of hepatic fat content (NAFLD off-label indication)
- Elevated IGF-1 within the age-adjusted reference range
- Preserved pulsatile GH release (vs continuous elevation with CJC-1295-DAC)
- Improved body composition (VAT down, lean mass preserved)
- Sustained VAT reduction through 52 weeks with continued dosing
- FDA-approved - the only GHRH secretagogue with that status
Tesofensine: potential benefits
- Significant weight loss (10-15% body weight)
- Appetite suppression
- Increased metabolic rate
- Enhanced dopamine-driven motivation
Frequently asked
What's the difference between Tesamorelin and Tesofensine?
Tesamorelin is a growth hormone / igf-1 axis that tesamorelin activates the same ghrh receptor (ghrhr) as endogenous ghrh and cjc-1295 / mod-grf 1-29, but with a distinct pharmacokinetic profile driven by its trans-3-hexenoyl…. Tesofensine is a weight loss that tesofensine blocks the presynaptic reuptake of three monoamine neurotransmitters: noradrenaline (norepinephrine), dopamine, and serotonin. by inhibiting the neurotransmitter…. The two differ in mechanism, half-life (30-50 minutes (plasma) vs not reported), and typical dose range.
Which has the longer half-life, Tesamorelin or Tesofensine?
Tesamorelin has a half-life of 30-50 minutes (plasma). Tesofensine has a half-life of not reported. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Tesamorelin or Tesofensine?
Lowest listed price on BodyHackGuide: Tesamorelin from $44.99, Tesofensine from $79.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack Tesamorelin and Tesofensine?
Stacking depends on mechanism overlap, safety profile, and goals. Tesamorelin and Tesofensine should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Before you buy Tesamorelin or Tesofensine
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.