Tesamorelin vs 5-Amino-1MQ
Side-by-side comparison of Tesamorelin and 5-Amino-1MQ: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Tesamorelin
5-Amino-1MQ
Tesamorelin
Tesamorelin is a stabilized synthetic analog of human growth hormone-releasing hormone (GHRH) — specifically the full 44-amino-acid GHRH sequence with a single N-terminal trans-3-hexenoyl fatty-acid modification. That…
Lowest listed price: $44.99 across 5 listings
Full Tesamorelin profile5-Amino-1MQ
5-Amino-1MQ (5-amino-1-methylquinolinium iodide) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide to…
Lowest listed price: $29.99 across 14 listings
Full 5-Amino-1MQ profileSide-by-side comparison
| Attribute | Tesamorelin | 5-Amino-1MQ |
|---|---|---|
| Category | Growth Hormone / IGF-1 Axis | Weight Loss |
| Research Stage | FDA Approved | Preclinical |
| Mechanism of Action | Tesamorelin activates the same GHRH receptor (GHRHR) as endogenous GHRH and CJC-1295 / MOD-GRF 1-29, but with a distinct pharmacokinetic profile driven by its trans-3-hexenoyl N-terminal modification. 1. GHRH receptor agonism (Gs / cAMP / PKA / CREB pathway) -… | 5-Amino-1MQ works by inhibiting nicotinamide N-methyltransferase (NNMT), an enzyme that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to the nitrogen of nicotinamide (vitamin B3 amide), producing 1-methylnicotinamide (1-MNA) and… |
| Half-Life | 8 to 11 minutes in healthy subjects (EGRIFTA SV and EGRIFTA WR labels) | ~6–12 hours (oral) |
| Typical Dose Range | 1,000–2,000 mcg (1–2 mg) daily | 50 mg - 150 mg daily (oral or injection) |
| Dosing Frequency | Once daily subcutaneous injection | Once daily oral |
| Administration | subcutaneous | Oral |
| Side Effects | Tesamorelin has a well-characterized side-effect profile from the FDA approval program, which is a significant advantage over non-approved GHRH analogs. Common (10% in Phase 3 trials) - Injection site reactions — erythema, pruritus, pain at site; most frequent… | The side effect profile of 5-amino-1MQ in humans is not documented because there are no human clinical trials. Rodent studies report generally good tolerability at doses producing metabolic and muscle benefits, without obvious signs of hepatotoxicity,… |
| Molecular Weight | 5135.9 Da | 159.21 g/mol |
| Common Vial Sizes | 2mg, 10mg | 50mg capsules, 100mg capsules |
Price History
3 data points- BM
- Half Nattys
- BHG Labs
Price History
5 data points- OF
- BM
- Half Nattys
- Ion Peptide
- Disguised Alpha
- RC
- LB
Tesamorelin: potential benefits
- Reduction of visceral adipose tissue (~15% at 26 weeks in the pivotal HIV trial; FDA-label indication)
- Reduction of hepatic fat content (NAFLD off-label indication)
- Higher IGF-1 (mean rise of about 81% at 26 weeks in the main Phase 3 trial, PMID 18057338)
- Preserved pulsatile GH release (vs continuous elevation with CJC-1295-DAC)
- Improved body composition (VAT down, lean mass preserved)
- Sustained VAT reduction through 52 weeks with continued dosing
- FDA-approved - the only GHRH secretagogue with that status
5-Amino-1MQ: potential benefits
- Enhanced fat metabolism and weight loss
- Increased NAD+ levels in adipose tissue
- Improved cellular energy production
- Anti-aging properties via sirtuin activation
Frequently asked
What's the difference between Tesamorelin and 5-Amino-1MQ?
Tesamorelin is a growth hormone / igf-1 axis that tesamorelin activates the same ghrh receptor (ghrhr) as endogenous ghrh and cjc-1295 / mod-grf 1-29, but with a distinct pharmacokinetic profile driven by its trans-3-hexenoyl…. 5-Amino-1MQ is a weight loss that 5-amino-1mq works by inhibiting nicotinamide n-methyltransferase (nnmt), an enzyme that catalyzes the transfer of a methyl group from s-adenosyl-l-methionine (sam) to the nitrogen…. The two differ in mechanism, half-life (8 to 11 minutes in healthy subjects (EGRIFTA SV and EGRIFTA WR labels) vs ~6–12 hours (oral)), and typical dose range.
Which has the longer half-life, Tesamorelin or 5-Amino-1MQ?
Tesamorelin has a half-life of 8 to 11 minutes in healthy subjects (EGRIFTA SV and EGRIFTA WR labels). 5-Amino-1MQ has a half-life of ~6–12 hours (oral). Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Tesamorelin or 5-Amino-1MQ?
Lowest listed price on BodyHackGuide: Tesamorelin from $44.99, 5-Amino-1MQ from $29.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack Tesamorelin and 5-Amino-1MQ?
Stacking depends on mechanism overlap, safety profile, and goals. Tesamorelin and 5-Amino-1MQ should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
See current vendor prices
Listings from the vendors we track. Prices change often, so check the vendor before you buy.
Before you buy Tesamorelin or 5-Amino-1MQ
Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor.
Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.