SS-31 vs Caffeine
Side-by-side comparison of SS-31 and Caffeine: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
SS-31
Caffeine
SS-31
SS-31 (elamipretide; MTP-131; formerly Bendavia; chemical sequence D-Arg-Dmt-Lys-Phe-NH2 with dimethyltyrosine at position 2) is a first-in-class aromatic-cationic tetrapeptide designed to selectively target the inner…
Lowest listed price: $72.00 across 4 listings
Full SS-31 profileCaffeine
Caffeine (1,3,7-trimethylxanthine) is a natural methylxanthine alkaloid found in the seeds, fruits, leaves, and bark of over 60 plant species — most notably Coffea (coffee), Camellia sinensis (tea), Theobroma cacao…
No vendor price on file.
Full Caffeine profileSide-by-side comparison
| Attribute | SS-31 | Caffeine |
|---|---|---|
| Category | Mitochondrial Peptides | Nootropics |
| Research Stage | Clinical/Approved | Approved (prescription) |
| Mechanism of Action | SS-31's mechanism of action is distinctive among mitochondrial interventions because it exploits a fundamental physical property of the inner mitochondrial membrane - the high concentration of cardiolipin, a signature mitochondrial anionic phospholipid - to… | Caffeine's mechanism is anchored in adenosine receptor antagonism but extends to several secondary pharmacological actions that together produce its characteristic profile of alertness, cognitive enhancement, cardiovascular effects, and metabolic activation.… |
| Half-Life | ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding | — |
| Typical Dose Range | 20-60 mg | — |
| Dosing Frequency | Once daily subcutaneous (some protocols use 5-6 days per week) | — |
| Administration | — | — |
| Side Effects | SS-31 (elamipretide) has been generally well-tolerated across clinical trials spanning over a decade of human exposure, with adverse event profiles dominated by injection site reactions rather than systemic toxicity. This favorable safety profile reflects both… | Caffeine's side effects range from minor acute effects to serious toxicity at extreme doses, with substantial individual variability reflecting genetic (CYP1A2), physiological, and psychological factors. Common acute side effects (dose-related): At typical… |
| Molecular Weight | 639.8 g/mol | — |
| Common Vial Sizes | — | — |
Price History
2 data points- Ion Peptide
- BHG Labs
Frequently asked
What's the difference between SS-31 and Caffeine?
SS-31 is a mitochondrial peptides that ss-31's mechanism of action is distinctive among mitochondrial interventions because it exploits a fundamental physical property of the inner mitochondrial membrane - the high…. Caffeine is a nootropics that caffeine's mechanism is anchored in adenosine receptor antagonism but extends to several secondary pharmacological actions that together produce its characteristic profile of…. The two differ in mechanism, half-life (~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding vs not reported), and typical dose range.
Which has the longer half-life, SS-31 or Caffeine?
SS-31 has a half-life of ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding. Caffeine has a half-life of not reported. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Can you stack SS-31 and Caffeine?
Stacking depends on mechanism overlap, safety profile, and goals. SS-31 and Caffeine should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.