Semaglutide vs Tesofensine
Side-by-side comparison of Semaglutide and Tesofensine: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Semaglutide
Tesofensine
Semaglutide
Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) with a molecular weight of 4113.58 Da and CAS number 910463-68-2. It is a 31-amino-acid peptide analog of human GLP-1(7-37) with two key structural…
Lowest listed price: $39.00 across 12 listings
Full Semaglutide profileTesofensine
Tesofensine (NS2330) is an orally-administered small-molecule triple monoamine reuptake inhibitor — it blocks the reuptake of noradrenaline, dopamine, and serotonin, placing it in the same broad pharmacologic class as…
Lowest listed price: $79.99 across 2 listings
Full Tesofensine profileSide-by-side comparison
| Attribute | Semaglutide | Tesofensine |
|---|---|---|
| Category | Metabolic & Weight Loss | Weight Loss |
| Research Stage | FDA Approved | Preclinical |
| Mechanism of Action | GLP-1 Receptor Agonism and cAMP Signaling Semaglutide binds to the GLP-1 receptor (GLP-1R), a class B G-protein coupled receptor expressed on pancreatic beta cells, hypothalamic neurons, gastric smooth muscle, cardiac myocytes, and other tissues. Upon binding,… | Tesofensine blocks the presynaptic reuptake of three monoamine neurotransmitters: noradrenaline (norepinephrine), dopamine, and serotonin. By inhibiting the neurotransmitter transporters (NET, DAT, and SERT respectively), tesofensine raises synaptic… |
| Half-Life | ~7 days (168 hours), enabled by C18 fatty diacid albumin-binding modification | — |
| Typical Dose Range | Diabetes (Ozempic): 250-1000 mcg weekly; Weight management (Wegovy): 2400 mcg weekly (after 16-week titration); Oral (Rybelsus): 3-14 mg daily | 0.25 mg - 1 mg daily (oral) |
| Dosing Frequency | Once weekly subcutaneous injection | — |
| Administration | Subcutaneous (weekly), Oral (daily) | — |
| Side Effects | Nausea (especially at initiation — dose-dependent), vomiting, diarrhea, constipation, abdominal pain, decreased appetite (therapeutic effect), headache, fatigue, dizziness. Rare: pancreatitis, gallbladder issues, thyroid C-cell tumors (rodent studies).… | Tesofensine's side effect profile reflects its monoamine-enhancing mechanism. Most effects are predictable extensions of NE, DA, and 5-HT elevation. The cardiovascular profile is the dominant clinical concern and the primary reason regulators have not approved… |
| Molecular Weight | 4113.6 Da | 298.24 g/mol |
| Common Vial Sizes | 3mg, 5mg, 10mg | — |
Price History
4 data points- OF
- Half Nattys
- Ion Peptide
- Disguised Alpha
Price tracking
Semaglutide: potential benefits
- Mean body weight reduction of 14.9% at 68 weeks in STEP 1 trial (PMID: 33567185)
- Sustained weight loss of ~15% (-15.2%) maintained through 104 weeks in STEP 5 trial (PMID: 36216945)
- 20% relative reduction in major adverse cardiovascular events (HR 0.80) in the SELECT trial (PMID: 37952131)
- HbA1c reduction of 1.5-1.8% in type 2 diabetes (SUSTAIN program)
- Reduction in systemic inflammation (lower hs-CRP) observed in SELECT
- Available in both subcutaneous (weekly) and oral (daily) formulations
- Improved cardiometabolic risk factors including blood pressure and lipid profile
Tesofensine: potential benefits
- Significant weight loss (10-15% body weight)
- Appetite suppression
- Increased metabolic rate
- Enhanced dopamine-driven motivation
Frequently asked
What's the difference between Semaglutide and Tesofensine?
Semaglutide is a metabolic & weight loss that glp-1 receptor agonism and camp signaling semaglutide binds to the glp-1 receptor (glp-1r), a class b g-protein coupled receptor expressed on pancreatic beta cells, hypothalamic…. Tesofensine is a weight loss that tesofensine blocks the presynaptic reuptake of three monoamine neurotransmitters: noradrenaline (norepinephrine), dopamine, and serotonin. by inhibiting the neurotransmitter…. The two differ in mechanism, half-life (~7 days (168 hours), enabled by C18 fatty diacid albumin-binding modification vs not reported), and typical dose range.
Which has the longer half-life, Semaglutide or Tesofensine?
Semaglutide has a half-life of ~7 days (168 hours), enabled by C18 fatty diacid albumin-binding modification. Tesofensine has a half-life of not reported. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Semaglutide or Tesofensine?
Lowest listed price on BodyHackGuide: Semaglutide from $39.00, Tesofensine from $79.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack Semaglutide and Tesofensine?
Stacking depends on mechanism overlap, safety profile, and goals. Semaglutide and Tesofensine should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
See current vendor prices
Listings from the vendors we track. Prices change often, so check the vendor before you buy.
Before you buy Semaglutide or Tesofensine
Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor.
Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.