RU-58841 vs Acetyl Hexapeptide-8
Side-by-side comparison of RU-58841 and Acetyl Hexapeptide-8: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
RU-58841
Acetyl Hexapeptide-8
RU-58841
RU-58841 (also known as PSK-3841 or HMR-3841, and commonly written simply as RU in hair-loss forums) is a non-steroidal androgen receptor antagonist originally developed by Roussel Uclaf (later absorbed into Sanofi) in…
Lowest listed price: $49.99 across 2 listings
Full RU-58841 profileAcetyl Hexapeptide-8
Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction.…
Lowest listed price: $129.00 across 1 listing
Full Acetyl Hexapeptide-8 profileSide-by-side comparison
| Attribute | RU-58841 | Acetyl Hexapeptide-8 |
|---|---|---|
| Category | Other | Skin & Hair |
| Research Stage | Preclinical | Marketed topical cosmetic ingredient (INCI: Acetyl Hexapeptide-8 / Argireline). Supported by small human anti-wrinkle studies, including one randomized, placebo-controlled trial; no systemic or injectable clinical development. Not an FDA-approved drug. |
| Mechanism of Action | RU-58841 is a non-steroidal androgen receptor (AR) antagonist with a chemical structure unrelated to testosterone, DHT, or the steroidal antiandrogens (cyproterone acetate, spironolactone). Its pharmacology was characterized in the early 1990s by teams at… | Acetyl Hexapeptide-8 (Argireline) is patterned after the N-terminal domain of SNAP-25 and behaves as a competitive mimic of that protein during SNARE complex assembly. The SNARE complex (SNAP-25 + Syntaxin-1 + VAMP/synaptobrevin) is required for… |
| Half-Life | — | Short (topical application, no systemic absorption at cosmetic doses) |
| Typical Dose Range | 25 mg - 50 mg topical daily (dissolved in vehicle) | — |
| Dosing Frequency | — | twice_daily |
| Administration | — | Topical |
| Side Effects | The side-effect profile of RU-58841 is not formally characterized in humans. What follows is a synthesis of the preclinical literature, the limited phase I human data, user-reported outcomes from hair-loss forums, and mechanistic inference from the broader… | — |
| Molecular Weight | 489.41 g/mol | 888.99 g/mol (average); molecular formula C34H60N14O12S |
| Common Vial Sizes | — | — |
Price History
2 data points- Half Nattys
- Disguised Alpha
Price tracking
RU-58841: potential benefits
- Prevention of hair follicle miniaturization
- Hair loss reduction (androgenic alopecia)
- Topical application minimizes systemic effects
- Alternative to finasteride without systemic 5-AR inhibition
Acetyl Hexapeptide-8: potential benefits
- Targets dynamic expression wrinkles - forehead, glabellar, and periorbital (crow's feet) lines
- Proposed to reduce facial neuromuscular signaling by destabilizing the ternary SNARE complex (acts as a SNAP-25 N-terminal mimic)
- A randomized, placebo-controlled human study reported ~49% subjective improvement in periorbital wrinkles vs 0% for placebo over 4 weeks (small evidence base) [PMID: 23417317]
- Marketed as a topical 'Botox alternative' - reversible mechanism, not a neurotoxin, with no botulinum-type systemic risk
- Supplied as a raw cosmetic-compounding powder for research/formulation use (verify purity via HPLC COA)
- Commonly combined with related peptides (e.g., Acetyl Octapeptide-3 / Snap-8) in anti-wrinkle formulations
Frequently asked
What's the difference between RU-58841 and Acetyl Hexapeptide-8?
RU-58841 is a other that ru-58841 is a non-steroidal androgen receptor (ar) antagonist with a chemical structure unrelated to testosterone, dht, or the steroidal antiandrogens (cyproterone acetate,…. Acetyl Hexapeptide-8 is a skin & hair that acetyl hexapeptide-8 (argireline) is patterned after the n-terminal domain of snap-25 and behaves as a competitive mimic of that protein during snare complex assembly. the snare…. The two differ in mechanism, half-life (not reported vs Short (topical application, no systemic absorption at cosmetic doses)), and typical dose range.
Which has the longer half-life, RU-58841 or Acetyl Hexapeptide-8?
RU-58841 has a half-life of not reported. Acetyl Hexapeptide-8 has a half-life of Short (topical application, no systemic absorption at cosmetic doses). Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, RU-58841 or Acetyl Hexapeptide-8?
Lowest listed price on BodyHackGuide: RU-58841 from $49.99, Acetyl Hexapeptide-8 from $129.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack RU-58841 and Acetyl Hexapeptide-8?
Stacking depends on mechanism overlap, safety profile, and goals. RU-58841 and Acetyl Hexapeptide-8 should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
See current vendor prices
Listings from the vendors we track. Prices change often, so check the vendor before you buy.
Before you buy RU-58841 or Acetyl Hexapeptide-8
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.