Retatrutide vs Tesofensine
Side-by-side comparison of Retatrutide and Tesofensine: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Retatrutide
Tesofensine
Retatrutide
Retatrutide (also coded LY3437943) is an investigational once-weekly triple-agonist at the GLP-1, GIP, and glucagon receptors. It is the third-generation incretin-based therapy developed by Eli Lilly. Where Semaglutide…
Lowest listed price: $79.99 across 11 listings
Full Retatrutide profileTesofensine
Tesofensine (NS2330) is an orally-administered small-molecule triple monoamine reuptake inhibitor — it blocks the reuptake of noradrenaline, dopamine, and serotonin, placing it in the same broad pharmacologic class as…
Lowest listed price: $79.99 across 2 listings
Full Tesofensine profileSide-by-side comparison
| Attribute | Retatrutide | Tesofensine |
|---|---|---|
| Category | Metabolic & Weight Loss | Weight Loss |
| Research Stage | Phase III | Preclinical |
| Mechanism of Action | Retatrutide is a 39-amino-acid synthetic peptide with balanced agonist activity at three receptors: GLP-1R, GIPR, and GCGR (glucagon receptor). It is chemically modified with a C20 fatty diacid side chain (similar to semaglutide) to bind albumin and extend its… | Tesofensine blocks the presynaptic reuptake of three monoamine neurotransmitters: noradrenaline (norepinephrine), dopamine, and serotonin. By inhibiting the neurotransmitter transporters (NET, DAT, and SERT respectively), tesofensine raises synaptic… |
| Half-Life | ~6 days (plasma, albumin-bound) | — |
| Typical Dose Range | 1,000–12,000 mcg (1–12 mg) per week | 0.25 mg - 1 mg daily (oral) |
| Dosing Frequency | Once weekly subcutaneous injection | — |
| Administration | subcutaneous | — |
| Side Effects | Retatrutide has a GLP-1-class side-effect profile with additional considerations from its GIP and glucagon receptor components. Common (10% of Phase 2 participants) - Nausea: most frequent adverse event; dose-related; typically worst in first 2-4 weeks of each… | Tesofensine's side effect profile reflects its monoamine-enhancing mechanism. Most effects are predictable extensions of NE, DA, and 5-HT elevation. The cardiovascular profile is the dominant clinical concern and the primary reason regulators have not approved… |
| Molecular Weight | 4731 g/mol | 298.24 g/mol |
| Common Vial Sizes | 5mg, 10mg | — |
Price History
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Retatrutide: potential benefits
- Body weight reduction up to 24% at 48 weeks (Phase 2 data)
- Glycemic control in T2DM: HbA1c reduction similar to tirzepatide
- Hepatic fat reduction: potential MASH/NAFLD therapeutic effect
- Modest increase in resting energy expenditure (3-5%)
- Preferential visceral fat reduction
- Blood pressure and lipid profile improvement (secondary to weight loss)
- Once-weekly dosing convenience
- Average weight loss of 28.3% at 80 weeks on 12 mg in the Phase 3 TRIUMPH-1 trial (Eli Lilly topline)
Tesofensine: potential benefits
- Significant weight loss (10-15% body weight)
- Appetite suppression
- Increased metabolic rate
- Enhanced dopamine-driven motivation
Frequently asked
What's the difference between Retatrutide and Tesofensine?
Retatrutide is a metabolic & weight loss that retatrutide is a 39-amino-acid synthetic peptide with balanced agonist activity at three receptors: glp-1r, gipr, and gcgr (glucagon receptor). it is chemically modified with a c20…. Tesofensine is a weight loss that tesofensine blocks the presynaptic reuptake of three monoamine neurotransmitters: noradrenaline (norepinephrine), dopamine, and serotonin. by inhibiting the neurotransmitter…. The two differ in mechanism, half-life (~6 days (plasma, albumin-bound) vs not reported), and typical dose range.
Which has the longer half-life, Retatrutide or Tesofensine?
Retatrutide has a half-life of ~6 days (plasma, albumin-bound). Tesofensine has a half-life of not reported. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Retatrutide or Tesofensine?
Lowest listed price on BodyHackGuide: Retatrutide from $79.99, Tesofensine from $79.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack Retatrutide and Tesofensine?
Stacking depends on mechanism overlap, safety profile, and goals. Retatrutide and Tesofensine should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Listings from the vendors we track. Prices change often, so check the vendor before you buy.
Before you buy Retatrutide or Tesofensine
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Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.