Retatrutide vs SLU-PP-332
Side-by-side comparison of Retatrutide and SLU-PP-332: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Retatrutide
SLU-PP-332
Retatrutide
Retatrutide (also coded LY3437943) is an investigational once-weekly triple-agonist at the GLP-1, GIP, and glucagon receptors. It is the third-generation incretin-based therapy developed by Eli Lilly. Where Semaglutide…
Lowest listed price: $79.99 across 11 listings
Full Retatrutide profileSLU-PP-332
SLU-PP-332 is the first-generation synthetic pan-agonist of the estrogen-related receptors (ERRα, ERRβ, ERRγ) developed by the laboratory of Thomas Burris at Saint Louis University and reported in a landmark 2023…
Lowest listed price: $69.99 across 5 listings
Full SLU-PP-332 profileSide-by-side comparison
| Attribute | Retatrutide | SLU-PP-332 |
|---|---|---|
| Category | Metabolic & Weight Loss | Performance |
| Research Stage | Phase III | Preclinical |
| Mechanism of Action | Retatrutide is a 39-amino-acid synthetic peptide with balanced agonist activity at three receptors: GLP-1R, GIPR, and GCGR (glucagon receptor). It is chemically modified with a C20 fatty diacid side chain (similar to semaglutide) to bind albumin and extend its… | SLU-PP-332 acts through pan-agonism of the three estrogen-related receptors (ERRα/NR3B1, ERRβ/NR3B2, ERRγ/NR3B3), a subfamily of orphan nuclear receptors that regulate oxidative metabolism, mitochondrial biogenesis, and exercise-responsive gene expression. The… |
| Half-Life | ~6 days (plasma, albumin-bound) | — |
| Typical Dose Range | 1,000–12,000 mcg (1–12 mg) per week | Research compound — no established human doses. Animal studies: 10-50 mg/kg |
| Dosing Frequency | Once weekly subcutaneous injection | — |
| Administration | subcutaneous | — |
| Side Effects | Retatrutide has a GLP-1-class side-effect profile with additional considerations from its GIP and glucagon receptor components. Common (10% of Phase 2 participants) - Nausea: most frequent adverse event; dose-related; typically worst in first 2-4 weeks of each… | The side effect profile of SLU-PP-332 in humans is undocumented because no clinical trials have been conducted. Rodent studies report generally acceptable tolerability at doses producing exercise-mimetic metabolic effects, without overt signs of toxicity on… |
| Molecular Weight | 4731 g/mol | 535.54 g/mol |
| Common Vial Sizes | 5mg, 10mg | — |
Price History
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Price History
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Retatrutide: potential benefits
- Body weight reduction up to 24% at 48 weeks (Phase 2 data)
- Glycemic control in T2DM: HbA1c reduction similar to tirzepatide
- Hepatic fat reduction: potential MASH/NAFLD therapeutic effect
- Modest increase in resting energy expenditure (3-5%)
- Preferential visceral fat reduction
- Blood pressure and lipid profile improvement (secondary to weight loss)
- Once-weekly dosing convenience
- Average weight loss of 28.3% at 80 weeks on 12 mg in the Phase 3 TRIUMPH-1 trial (Eli Lilly topline)
SLU-PP-332: potential benefits
- Exercise mimicry without physical exertion
- Enhanced fat oxidation
- Increased mitochondrial biogenesis
- Improved endurance capacity
- Muscle fiber type conversion
- Metabolic health improvement
Frequently asked
What's the difference between Retatrutide and SLU-PP-332?
Retatrutide is a metabolic & weight loss that retatrutide is a 39-amino-acid synthetic peptide with balanced agonist activity at three receptors: glp-1r, gipr, and gcgr (glucagon receptor). it is chemically modified with a c20…. SLU-PP-332 is a performance that slu-pp-332 acts through pan-agonism of the three estrogen-related receptors (errα/nr3b1, errβ/nr3b2, errγ/nr3b3), a subfamily of orphan nuclear receptors that regulate oxidative…. The two differ in mechanism, half-life (~6 days (plasma, albumin-bound) vs not reported), and typical dose range.
Which has the longer half-life, Retatrutide or SLU-PP-332?
Retatrutide has a half-life of ~6 days (plasma, albumin-bound). SLU-PP-332 has a half-life of not reported. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Retatrutide or SLU-PP-332?
Lowest listed price on BodyHackGuide: Retatrutide from $79.99, SLU-PP-332 from $69.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack Retatrutide and SLU-PP-332?
Stacking depends on mechanism overlap, safety profile, and goals. Retatrutide and SLU-PP-332 should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.