Retatrutide vs 5-Amino-1MQ
Side-by-side comparison of Retatrutide and 5-Amino-1MQ: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Retatrutide
5-Amino-1MQ
Retatrutide
Retatrutide (also coded LY3437943) is an investigational once-weekly triple-agonist at the GLP-1, GIP, and glucagon receptors. It is the third-generation incretin-based therapy developed by Eli Lilly. Where Semaglutide…
Lowest listed price: $79.99 across 11 listings
Full Retatrutide profile5-Amino-1MQ
5-Amino-1MQ (5-amino-1-methylquinolinium iodide) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide to…
Lowest listed price: $29.99 across 14 listings
Full 5-Amino-1MQ profileSide-by-side comparison
| Attribute | Retatrutide | 5-Amino-1MQ |
|---|---|---|
| Category | Metabolic & Weight Loss | Weight Loss |
| Research Stage | Phase III | Preclinical |
| Mechanism of Action | Retatrutide is a 39-amino-acid synthetic peptide with balanced agonist activity at three receptors: GLP-1R, GIPR, and GCGR (glucagon receptor). It is chemically modified with a C20 fatty diacid side chain (similar to semaglutide) to bind albumin and extend its… | 5-Amino-1MQ works by inhibiting nicotinamide N-methyltransferase (NNMT), an enzyme that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to the nitrogen of nicotinamide (vitamin B3 amide), producing 1-methylnicotinamide (1-MNA) and… |
| Half-Life | ~6 days (plasma, albumin-bound) | ~6–12 hours (oral) |
| Typical Dose Range | 1,000–12,000 mcg (1–12 mg) per week | 50 mg - 150 mg daily (oral or injection) |
| Dosing Frequency | Once weekly subcutaneous injection | Once daily oral |
| Administration | subcutaneous | Oral |
| Side Effects | Retatrutide has a GLP-1-class side-effect profile with additional considerations from its GIP and glucagon receptor components. Common (10% of Phase 2 participants) - Nausea: most frequent adverse event; dose-related; typically worst in first 2-4 weeks of each… | The side effect profile of 5-amino-1MQ in humans is not documented because there are no human clinical trials. Rodent studies report generally good tolerability at doses producing metabolic and muscle benefits, without obvious signs of hepatotoxicity,… |
| Molecular Weight | 4731 g/mol | 159.21 g/mol |
| Common Vial Sizes | 5mg, 10mg | 50mg capsules, 100mg capsules |
Price History
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Retatrutide: potential benefits
- Body weight reduction up to 24% at 48 weeks (Phase 2 data)
- Glycemic control in T2DM: HbA1c reduction similar to tirzepatide
- Hepatic fat reduction: potential MASH/NAFLD therapeutic effect
- Modest increase in resting energy expenditure (3-5%)
- Preferential visceral fat reduction
- Blood pressure and lipid profile improvement (secondary to weight loss)
- Once-weekly dosing convenience
- Mean weight loss of 25.0% at 80 weeks on 12 mg in the Phase 3 TRIUMPH-1 trial for everyone randomized (treatment-regimen estimand, NEJM 2026); 28.3% in Lilly's efficacy-estimand topline
5-Amino-1MQ: potential benefits
- Enhanced fat metabolism and weight loss
- Increased NAD+ levels in adipose tissue
- Improved cellular energy production
- Anti-aging properties via sirtuin activation
Frequently asked
What's the difference between Retatrutide and 5-Amino-1MQ?
Retatrutide is a metabolic & weight loss that retatrutide is a 39-amino-acid synthetic peptide with balanced agonist activity at three receptors: glp-1r, gipr, and gcgr (glucagon receptor). it is chemically modified with a c20…. 5-Amino-1MQ is a weight loss that 5-amino-1mq works by inhibiting nicotinamide n-methyltransferase (nnmt), an enzyme that catalyzes the transfer of a methyl group from s-adenosyl-l-methionine (sam) to the nitrogen…. The two differ in mechanism, half-life (~6 days (plasma, albumin-bound) vs ~6–12 hours (oral)), and typical dose range.
Which has the longer half-life, Retatrutide or 5-Amino-1MQ?
Retatrutide has a half-life of ~6 days (plasma, albumin-bound). 5-Amino-1MQ has a half-life of ~6–12 hours (oral). Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Retatrutide or 5-Amino-1MQ?
Lowest listed price on BodyHackGuide: Retatrutide from $79.99, 5-Amino-1MQ from $29.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack Retatrutide and 5-Amino-1MQ?
Stacking depends on mechanism overlap, safety profile, and goals. Retatrutide and 5-Amino-1MQ should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.